Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis.
H. F. Petereit,Wolf-Dieter Heiss +1 more
TL;DR: One year after symptom onset, more than three times as many patients with CIS were diagnosed with MS using new diagnostic criteria incorporating MRI results compared to older criteria, however, the proposed MRI criteria require further prospective studies to optimize sensitivity and specificity.
Journal ArticleDOI
HLA-G expression defines a novel regulatory T cell subset present in human peripheral blood and sites of inflammation
Ute Feger,Eva Tolosa,Yu-Hwa Huang,Anne Waschbisch,Tilo Biedermann,Arthur Melms,Heinz Wiendl,Heinz Wiendl +7 more
TL;DR: The presence of HLA-G(pos) T cells at sites of inflammation such as inflamed skeletal muscle in myositis or the cerebrospinal fluid of patients with acute neuroinflammatory disorders suggests an important function in modulating parenchymal inflammatory responses in vivo.
Journal ArticleDOI
Epidemiology of multiple sclerosis in Iran: a systematic review.
Masoud Etemadifar,Sepideh Sajjadi,Zahra Nasr,Toktam Sadat Firoozeei,Seyed-Hossein Abtahi,Mojtaba Akbari,Mahboobeh Fereidan-Esfahani +6 more
TL;DR: The incidence and prevalence of multiple sclerosis in Iran has been increasing rapidly, especially in females, and future research should focus on determining the epidemiological features of MS in the neglected provinces with different ethnicities.
Journal ArticleDOI
The utility of cerebrospinal fluid analysis in patients with multiple sclerosis
Martin Stangel,Sten Fredrikson,Edgar Meinl,Axel Petzold,Axel Petzold,Olaf Stüve,Hayrettin Tumani +6 more
TL;DR: CSF findings that shed light on the differential diagnosis of MS are summarized, the potential of novel biomarkers for this disease that could advance understanding of its pathophysiology are highlighted.
Journal ArticleDOI
A second major histocompatibility complex susceptibility locus for multiple sclerosis
Tai Wai Yeo,Philip L. De Jager,Simon G. Gregory,Lisa F. Barcellos,Lisa F. Barcellos,Amie Walton,An Goris,Chiara Fenoglio,Chiara Fenoglio,Maria Ban,Craig J. Taylor,Reyna S. Goodman,Emily Walsh,Cara S Wolfish,Roger Horton,James A. Traherne,Stephan Beck,John Trowsdale,Stacy J. Caillier,Adrian J. Ivinson,Todd Green,Susan Pobywajlo,Eric S. Lander,Margaret A. Pericak-Vance,Jonathan L. Haines,Mark J. Daly,Jorge R. Oksenberg,Stephen L. Hauser,Alastair Compston,David A. Hafler,John D. Rioux,Stephen Sawcer +31 more
TL;DR: Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA‐DRB1 gene in the class II region.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
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The clinical course of neuromyelitis optica (Devic's syndrome)
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Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
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Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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