Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Regulatory T cells fail to suppress CD4+ T‐bet+ T cells in relapsing multiple sclerosis patients
Giovanni Frisullo,Viviana Nociti,Raffaele Iorio,Agata Katia Patanella,Marcella Caggiula,Alessandro Marti,Cristina Sancricca,Francesco Angelucci,Massimiliano Mirabella,Pietro Attilio Tonali,Anna Paola Batocchi +10 more
TL;DR: The data indicate that the increased number of regulatory T (T‐reg) cells and the increased Foxp3 expression in circulating CD4+ CD25+ T cells may contribute to the maintenance of tolerance in the remission phase of MS.
Journal ArticleDOI
Impact of sleep disorder treatment on fatigue in multiple sclerosis.
isabelle cote,Daria A. Trojan,Marta Kaminska,Mauro Cardoso,Andrea Benedetti,D Weiss,A Robinson,Amit Bar-Or,Yves Lapierre,R.J. Kimoff +9 more
TL;DR: Treatment of sleep disorders can improve fatigue and other clinical outcomes in MS.
Journal ArticleDOI
Vitamin D for the treatment of multiple sclerosis: a meta-analysis.
Laurie Mclaughlin,Laura Clarke,Elham Khalilidehkordi,Helmut Butzkueven,Bruce V. Taylor,Simon Broadley +5 more
TL;DR: It is suggested that vitamin D supplementation may have a therapeutic role in the treatment of MS, however, there is uncertainty with regard to the most appropriate dose, with high doses potentially being associated with worse outcomes.
Journal ArticleDOI
Sjögren's syndrome at the crossroad of polyautoimmunity.
Manuel J. Amador-Patarroyo,Juan Arbelaez,Rubén D. Mantilla,Alberto Rodriguez-Rodriguez,Jorge Cárdenas-Roldán,Ricardo Pineda-Tamayo,Mayra R. Guarin,Mayra R. Guarin,Liliana López Kleine,Adriana Rojas-Villarraga,Juan-Manuel Anaya +10 more
TL;DR: A high prevalence of polyautoimmunity in Sjögren's syndrome, its associated risk factors and the grouping pattern of such a condition are disclosed to define plausible approaches to study the common mechanisms of autoimmune diseases.
Journal ArticleDOI
Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis
TL;DR: Antibodies against native glycosylated myelin-oligodendrocyte-glycoprotein (MOG) were measured by ELISA in patients with multiple sclerosis and controls to identify a potential biomarker for MS.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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