Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Journal ArticleDOI
T-bet inhibits innate lymphoid cell–mediated eosinophilic airway inflammation by suppressing IL-9 production
Ayako Matsuki,Hiroaki Takatori,Sohei Makita,Masaya Yokota,Tomohiro Tamachi,Akira Suto,Kotaro Suzuki,Koichi Hirose,Hiroshi Nakajima +8 more
TL;DR: T‐bet suppresses IL‐9 production from lung ILC2s and thereby inhibits IL‐33–induced eosinophilic airway inflammation, which is associated with lung type 2 innate lymphoid cells (ILC2s).
Journal ArticleDOI
Vitexin inhibits inflammation in murine ovalbumin-induced allergic asthma.
Claudio Luis Venturini,Antonio Macho,Karuppusamy Arunachalam,Danielle Ayr Tavares de Almeida,Suellen Iara Guirra Rosa,Eduarda Pavan,Sikiru Olaitan Balogun,Amílcar Sabino Damazo,Domingos Tabajara de Oliveira Martins +8 more
TL;DR: In this paper, the anti-hypersensitive activity of vitexin in a murine ovalbumin (OVA)-induced allergic asthma model was evaluated in a mouse.
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Combination biologic therapy for severe persistent asthma.
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Current and future targeted therapies for severe asthma: Managing treatment with biologics based on phenotypes and biomarkers.
TL;DR: The aim of the present narrative review is to discuss and examine the indication, mechanisms of action and therapeutic effects of currently available and emerging biologic agents for the treatment of severe asthma.
Journal ArticleDOI
Viruses and non-allergen environmental triggers in asthma.
Florence Chau-Etchepare,Joshua L Hoerger,Brooks Kuhn,Amir A. Zeki,Angela Franciska Haczku,Samuel Louie,Nicholas J. Kenyon,Cristina E. Davis,Michael Schivo +8 more
TL;DR: A new clinical approach that collects exhaled breath condensates to identify metabolomics associated with viruses and non-allergen triggers that may promote the early management of asthma symptoms is introduced.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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