Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Journal ArticleDOI
TLR9-IL-2 axis exacerbates allergic asthma by preventing IL-17A hyperproduction.
TL;DR: The results suggest that the TLR 9–IL-2 axis plays an important role in Th2 inflammation by modulating IL-17A production in HDM-induced allergic asthma and that targeting of TLR9 might be a novel therapeutic method for allergic asthma.
Journal ArticleDOI
Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze.
Hanna M. Knihtilä,Rachel S. Kelly,Nicklas Brustad,Nicklas Brustad,Mengna Huang,Priyadarshini Kachroo,Bo L. Chawes,Jakob Stokholm,Klaus Bønnelykke,Casper-Emil T. Pedersen,Hans Bisgaard,Augusto A. Litonjua,Jessica Lasky-Su,Scott T. Weiss +13 more
TL;DR: In this article, the effect of maternal rs12936231 genotype variation on the protective effect of prenatal vitamin D3 supplementation against offspring asthma/recurrent wheeze was investigated.
Journal ArticleDOI
Ribosomal protein S3 gene silencing protects against experimental allergic asthma.
Jinrui Dong,Wupeng Liao,Hong Yong Peh,Tze Khee Chan,Tze Khee Chan,W.S. Daniel Tan,Li Li,Amy Yong,W.S. Fred Wong,W.S. Fred Wong +9 more
TL;DR: It is hypothesized that gene silencing of lung RPS3 can ameliorate allergic airway inflammation and is associated with good prognosis for asthma.
Journal ArticleDOI
Therapeutic and prophylactic deletion of IL-4Ra-signaling ameliorates established ovalbumin induced allergic asthma.
Jermaine Khumalo,Jermaine Khumalo,Frank Kirstein,Martyna Scibiorek,Martyna Scibiorek,Sabelo Hadebe,Frank Brombacher,Frank Brombacher,Frank Brombacher +8 more
TL;DR: Anti‐TH2 therapies have the potential to effectively reduce airway obstruction and inflammation in allergic asthma.
Journal ArticleDOI
The Influence of Asthma and/or Hay Fever on Pregnancy: Data from the 1995 National Survey of Family Growth
TL;DR: This study provides new data that the allergic phenotypes, asthma and hay fever and hay Fever only, are compatible with healthy pregnancy, whereas the nonatopic asthma phenotype, asthma only, adversely impacts pregnancy.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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