Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
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Surfactant Protein D in Respiratory and Non-Respiratory Diseases.
TL;DR: The reported genetic associations ofSP-D with disease and the clinical utility of circulating SP-D for respiratory disease prognosis are summarized and basic research on the mechanistic links between SP- D and respiratory, cardiovascular, and metabolic diseases is summarized.
Journal ArticleDOI
Toward clinically applicable biomarkers for asthma: An EAACI position paper.
Zuzana Diamant,Zuzana Diamant,Susanne J. H. Vijverberg,Kjell Alving,Arzu Bakirtas,Leif Bjermer,Adnan Custovic,Sven-Erik Dahlén,Mina Gaga,Roy Gerth van Wijk,Stefano Del Giacco,Eckard Hamelmann,Eckard Hamelmann,Liam G Heaney,Enrico Heffler,Omer Kalayci,Konstantinos Kostikas,René Lutter,Anna-Carin Olin,Svetlana Sergejeva,Angela Simpson,Peter J. Sterk,Ellen Tufvesson,Ioana Agache,Sven Seys +24 more
TL;DR: The European Academy of Allergy & Clinical Immunology Task Force on Biomarkers in Asthma was initiated to investigate clinical applicability of new and existing inflammatory biomarkers (point‐of‐care) to support diagnosis, targeted treatment, and monitoring of severe asthma.
Journal ArticleDOI
Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation.
Yin Yao,Xing-Liang Fan,Dan Jiang,Yuelin Zhang,Xin Li,Zhi-Bin Xu,Shu-Bin Fang,Sinming Chiu,Hung-Fat Tse,Qizhou Lian,Qing-Ling Fu +10 more
TL;DR: iPSC-MSC transplantation significantly reduced T helper 2 cytokines, attenuated the mitochondrial dysfunction of epithelial cells, and alleviated asthma inflammation in mice, providing a therapeutic strategy for targeting asthma inflammation.
Journal ArticleDOI
Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis.
Yuki Morimoto,Kiyoshi Hirahara,Masahiro Kiuchi,Tomoko Wada,Tomomi Ichikawa,Toshio Kanno,Mikiko Okano,Kota Kokubo,Atsushi Onodera,Daiju Sakurai,Yoshitaka Okamoto,Toshinori Nakayama +11 more
TL;DR: The IL‐33‐ST2‐amphiregulin‐EGRF‐osteopontin axis directs fibrotic responses in eosinophilic airway inflammation and is a potential target for the treatment of fibrosis induced by chronic allergic disorders.
Journal ArticleDOI
The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation
TL;DR: Recent advances in understanding of the mechanism controlling apoptotic cell recognition and removal from the lung in homeostasis and during inflammation are discussed and implications of the signals triggered by apoptotic cells in the susceptibility to pulmonary microbial infections are discussed.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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