Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach
TL;DR: The steps that led PARP inhibition to become a possible future therapeutic strategy against allergic asthma are summarized and discussed.
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Treatment Eligibility of Real-life Mepolizumab-treated Severe Asthma Patients.
Levi B. Richards,Job J.M.H. van Bragt,Reim Aarab,Cristina Longo,Anne H. Neerincx,J. K. Sont,Els J.M. Weersink,Gert-Jan Braunstahl,Anneke ten Brinke,Elisabeth H. Bel,Anke-Hilse Maitland-van der Zee +10 more
TL;DR: A large proportion of the real-life, mepolizumab-treated severe asthma population would be excluded from trial participation and significant differences in population characteristics exist.
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The role of endosomal toll-like receptors in asthma.
Andriana I. Papaioannou,Aris Spathis,Konstantinos Kostikas,Petros Karakitsos,Spyros Papiris,Christos Rossios +5 more
TL;DR: Endosomal TLRs have been shown to be associated with the induction of asthmatic inflammation, and with disease exacerbations, and their potential use as targets for the development of novel treatments for the therapy of asthma is provided.
Journal ArticleDOI
Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells
Zhou Zhou,Xiuzhen Li,Xiuzhen Li,Yisong Qian,Yisong Qian,Cynthia Liu,Xiaotian Huang,Mingui Fu +7 more
TL;DR: Geldanamycin, an HSP90 inhibitor, profoundly rescued THP-1 cells from pyroptosis induced by LPS plus Nigericin treatment and may be a potential therapeutic strategy in the treatment of inflammatory diseases in which pyroPTosis plays a role.
Journal ArticleDOI
A potential mechanism of the onset of acute eosinophilic pneumonia triggered by an anti‐PD‐1 immune checkpoint antibody in a lung cancer patient
Takayuki Jodai,Chieko Yoshida,Ryo Sato,Yosuke Kakiuchi,Nahoko Sato,Shinji Iyama,Tomoko Kimura,Koichi Saruwatari,Sho Saeki,Hidenori Ichiyasu,Kazuhiko Fujii,Yusuke Tomita +11 more
TL;DR: The impact of immune checkpoint blockade on immunity in cancer patients is not completely elucidated, but a significant role of programed cell death‐ligand 2 in negatively controlling the production of CD4+ T helper type 2 (Th2) cytokines and airway hypersensitiveness is revealed.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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