Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
Daniela F. Quail,Oakley C. Olson,Priya Bhardwaj,Logan A. Walsh,Leila Akkari,Leila Akkari,Leila Akkari,Marsha L. Quick,I-Chun Chen,Nils K. Wendel,Nir Ben-Chetrit,Nir Ben-Chetrit,Jeanne M. Walker,Peter R. Holt,Andrew J. Dannenberg,Johanna A. Joyce,Johanna A. Joyce,Johanna A. Joyce +17 more
TL;DR: It is demonstrated that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour, and weight loss is sufficient to reverse this effect, and reduce serum levels of GM-CSF and IL5 in both mouse models and humans.
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Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Emma Persson,Kenneth Verstraete,Ines Heyndrickx,Elien Gevaert,Helena Catharine Aegerter,Jean-Michel Percier,Kim Deswarte,K. Verschueren,Ann Dansercoer,Delphine Gras,Pascal Chanez,Claus Bachert,Claus Bachert,Amanda Gonçalves,H. Van Gorp,H. De Haard,Christophe Blanchetot,Michael A. Saunders,Hamida Hammad,Savvas N. Savvides,Bart N. Lambrecht +20 more
TL;DR: Recombinant Gal10 crystals were produced that were structurally and biochemically similar to CLCs obtained from patients with rhinosinusitis and asthma and generated antibodies against crystalline Gal10, suggesting a potential therapeutic approach for crystallopathies more broadly.
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Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants
Kathrin Reinmuth-Selzle,Christopher J. Kampf,Kurt Lucas,Naama Lang-Yona,Janine Fröhlich-Nowoisky,Manabu Shiraiwa,Pascale S. J. Lakey,Senchao Lai,Fobang Liu,Anna T. Kunert,Kira Ziegler,Fangxia Shen,Rossella Sgarbanti,Bettina Weber,Iris Bellinghausen,Joachim Saloga,Michael G. Weller,Albert Duschl,Detlef Schuppan,Detlef Schuppan,Ulrich Pöschl +20 more
TL;DR: An overview of physical, chemical and biological interactions between air pollution, climate change, allergens, adjuvants and the immune system, addressing how these interactions may promote the development of allergies is provided.
Journal ArticleDOI
First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment
Simona Saluzzo,Simona Saluzzo,Simona Saluzzo,Anna-Dorothea Gorki,Anna-Dorothea Gorki,Batika M. J. Rana,Rui Martins,Rui Martins,Seth T. Scanlon,Philipp Starkl,Philipp Starkl,Karin Lakovits,Karin Lakovits,Anastasiya Hladik,Anastasiya Hladik,Ana Korosec,Ana Korosec,Omar Sharif,Omar Sharif,Joanna Warszawska,Joanna Warszawska,Helen E. Jolin,Ildiko Mesteri,Andrew N. J. McKenzie,Sylvia Knapp,Sylvia Knapp +25 more
TL;DR: The homeostatic role of ILC2s in setting the activation threshold in the lung and underline their implications in anti-bacterial defenses are highlighted.
Journal ArticleDOI
Cellular mechanisms underlying eosinophilic and neutrophilic airway inflammation in asthma.
Girolamo Pelaia,Alessandro Vatrella,Maria Teresa Busceti,Luca Gallelli,Cecilia Calabrese,Rosa Terracciano,Rosario Maselli +6 more
TL;DR: The recent advances in the knowledge of the cellular and molecular mechanisms underlying asthmatic inflammation are contributing to the identification of novel therapeutic targets, potentially suitable for the implementation of future improvements in antiasthma pharmacologic treatments.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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