Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Journal ArticleDOI
Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load.
Sabelo Hadebe,Jermaine Khumalo,Jermaine Khumalo,Sandisiwe Mangali,Sandisiwe Mangali,Nontobeko Mthembu,Nontobeko Mthembu,Hlumani Ndlovu,Martyna Scibiorek,Martyna Scibiorek,Amkele Ngomti,Amkele Ngomti,Frank Kirstein,Frank Brombacher,Frank Brombacher,Frank Brombacher +15 more
TL;DR: This paper found that IL-4Rα signalling on B cells was important for optimal TH2 allergic immune responses mainly when the load of antigen is limited, especially for germinal centres (GC) and in effector phase of allergic responses.
Journal ArticleDOI
Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma
Jing Xu,Congshan Jiang,Shemin Lu +2 more
TL;DR: This review describes neuro-immune regulation in inflammation of allergic asthma from two aspects: innate immunity and adaptive immunity and introduces neuro- immune regulation in airway remodeling of asthma.
Journal ArticleDOI
Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model
Anne-Charlotte Jonckheere,Sven Seys,Brecht Steelant,Tatjana Decaesteker,Kaat Dekoster,Jonathan Cremer,Ellen Dilissen,Dominique Schols,Yoichiro Iwakura,Greetje Vande Velde,Christine Breynaert,Rik Schrijvers,Jeroen Vanoirbeek,Jan Ceuppens,Lieven Dupont,Dominique Bullens +15 more
TL;DR: A murine model for neutrophilic asthma where ILC are required to induce airway hyperreactivity is developed and found that repeated endonasal applications of low-dose LPS in BALB/c mice led to AHR, BAL neutrophilia, and a significant increase in lung ILC3.
Journal ArticleDOI
Lung eosinophils elicited during allergic and acute aspergillosis express RORγt and IL-23R but do not require IL-23 for IL-17 production.
Bhawna Yadav,Charles A. Specht,Chrono K. Lee,Maria Pokrovskii,Jun R. Huh,Jun R. Huh,Dan R. Littman,Dan R. Littman,Stuart M. Levitz +8 more
TL;DR: In this article, lung eosinophils expressed RORγt, the master transcription factor for IL-17 regulation, in response to live conidia and antigens of A. fumigatus.
Dissertation
Interactions filaire/poumon dans le modèle murin de filariose Litosomoides sigmodontis
TL;DR: Le passage des L3 induit aussi une inflammation des vaisseaux sanguins pulmonaires chez les souris C57BL/6 seulement, ainsi que la baisse d'expression de molecules inflammatoires est egalement observee dans le tissu pulmonaire.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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