Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Endoplasmic Reticulum Stress and Allergic Diseases
TL;DR: Recently, stress responses originate from the endoplasmic reticulum (ER) and the associated inflammatory molecular platform has been suggested as a crucial player of immune and inflammatory responses, implying that ER stress-related pathways may represent a new endotype-driven therapeutic strategy in the treatment of allergic diseases.
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Codonopsis lanceolata attenuates allergic lung inflammation by inhibiting Th2 cell activation and augmenting mitochondrial ROS dismutase (SOD2) expression.
TL;DR: It is indicated that Codonopsis lanceolata extract has potential as a novel therapeutic agent to inhibit Th2 cell differentiation by regulating mROS scavenging and increase the number of macrophages in the lungs and enhanced the immune-suppressive property of Macrophages.
Journal ArticleDOI
Progress in the understanding of the pathology of allergic asthma and the potential of fruit proanthocyanidins as modulators of airway inflammation
Sara L. Coleman,Odette M. Shaw +1 more
TL;DR: Advances in understanding of the pathophysiology of allergic asthma are discussed, including the role of the microbiome in lung immune function, and how proanthocyanidins modulate the airway inflammation are discussed.
Journal ArticleDOI
Maternal exposure to environmental DEHP exacerbated OVA-induced asthmatic responses in rat offspring
TL;DR: Maternal exposure to DEHP during pregnancy and lactation aggravated the eosinophils accumulation and the pathological inflammatory changes in pups' lung after OVA challenge and elevated the levels of typical Th2 cytokines in OVA-challenged rats, and this adjuvant effect of DEHP was related with the TSLP/TSLPR/IL-7R and its downstream signal pathways.
Journal ArticleDOI
Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation
Marit Ilves,Pia Anneli Sofia Kinaret,Pia Anneli Sofia Kinaret,Joseph Ndika,Piia Karisola,Veer Singh Marwah,Veer Singh Marwah,Vittorio Fortino,Vittorio Fortino,Yuri Fedutik,Manuel Correia,Nicky Ehrlich,Katrin Loeschner,Alexandros Besinis,J. Vassallo,Richard D. Handy,Henrik Wolff,Henrik Wolff,Kai Savolainen,Dario Greco,Dario Greco,Harri Alenius,Harri Alenius +22 more
TL;DR: CuO as well as its functionalized forms worsen allergic airway inflammation by causing neutrophilia in the lungs, however, the results show that surface PEGylation can be a promising approach for inhibiting the effects of pristine CuO.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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