Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
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House dust mite-driven asthma and allergen-specific T cells depend on B cells when the amount of inhaled allergen is limiting.
Melissa Dullaers,Melissa Dullaers,Martijn J. Schuijs,Martijn J. Schuijs,Monique Willart,Monique Willart,Kaat Fierens,Kaat Fierens,Justine Van Moorleghem,Justine Van Moorleghem,Hamida Hammad,Hamida Hammad,Bart N. Lambrecht,Bart N. Lambrecht,Bart N. Lambrecht +14 more
TL;DR: B cells are a major part of the adaptive immune response to inhaled HDM allergen, particularly when the amount of inhaledallergen is low, by expanding allergenic‐specific T cells.
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Pulmonary Extracellular Vesicles as Mediators of Local and Systemic Inflammation.
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Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell–mediated airway hyperreactivity
Hadi Maazi,Homayon Banie,German R. Aleman Muench,Nisheel Patel,Bowen Wang,Ishwarya Sankaranarayanan,Vipul Bhargava,Takahiro Sato,Gavin Lewis,Gavin Lewis,Matteo Cesaroni,James G. Karras,Anuk Das,Pejman Soroosh,Omid Akbari +14 more
TL;DR: Activation of pDCs alleviates AHR and airway inflammation by suppressing ILC2 function and survival, revealing a novel regulatory pathway in ILC1‐mediated pulmonary inflammation with important clinical implications.
Reply to comment on chest-10-1440 : Increased airway T regulatory cells in asthmatic subjects
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Perinatal and Early-Life Nutrition, Epigenetics, and Allergy.
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References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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