Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
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Transient Receptor Potential (TRP) Channels in Airway Toxicity and Disease: An Update
TL;DR: TRP channels as future pharmacological targets in chronic obstructive pulmonary disease (COPD), asthma, cystic and pulmonary fibrosis as well as lung edema are discussed.
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The emerging role of exosomes in innate immunity, diagnosis and therapy
Prakash Gangadaran,Harishkumar Madhyastha,Radha Madhyastha,Ramya Lakshmi Rajendran,Yuichi Nakajima,Nozomi Watanabe,Anoop Kumar G. Velikkakath,Chae Moon Hong,R. Gopi,Gothandam K. Muthukalianan,Abilash Valsala Gopalakrishnan,Madhan Jeyaraman,Byeong-Cheol Ahn +12 more
TL;DR: In this paper , the authors discuss the role of exosomes in immunotherapy, including those against autoimmune connective tissue diseases, and elucidated their views on the major issues in immune-related pathophysiological processes.
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Advances and Highlights of miRNAs in Asthma: Biomarkers for Diagnosis and Treatment
Marta Gil-Martínez,Clara Lorente-Sorolla,Sara Naharro,José M Rodrigo-Muñoz,Victoria del Pozo +4 more
TL;DR: In this article , the role of microRNAs in asthma is discussed and the current state of miRNAs as biomarkers for asthma phenotyping, endotyping and treatment selection.
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Pathogenicity of acquired immunity in human diseases.
TL;DR: The diversity of CD4 T cell subsets is revealed, and emerging data indicate that CD4 helper T cells show increased plasticity, which is critical for shaping the pathology of fibrosis during chronic allergic inflammation.
Posted ContentDOI
Mechanisms and kinetics of bacterial clearance after experimental colonisation in adults with asthma
Seher Zaidi,Seher Zaidi,Simon P. Jochems,Jesús Reiné,Sherin Pojar,Elissavet Nikolaou,Elena Mitsi,Esther L. German,Angela D. Hyder-Wright,Angela D. Hyder-Wright,Hugh Adler,Hugh Adler,Helen Hill,Helen Hill,Caroline Hales,Caroline Hales,Victoria Connor,Victoria Connor,Carla Solórzano,Stephen B. Gordon,John D Blakey,David Goldblatt,Daniela M. Ferreira,Jamie Rylance +23 more
TL;DR: People with asthma on inhaled corticosteroids have an increased likelihood of pneumococcal infection secondary to reduced mucosal immune responses from nasopharyngeal colonisation and a lack of protection from re-exposure.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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