Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness
Shanru Li,Cynthia J. Koziol-White,Joseph A. Jude,Meiqi Jiang,Hengjiang Zhao,Gaoyuan Cao,Edwin J. Yoo,William Jester,Michael Morley,Su Zhou,Yi Wang,Min Min Lu,Reynold A. Panettieri,Edward E. Morrisey +13 more
TL;DR: It is determined that NPY promotes AHR through the induction of Rho kinase activity and phosphorylation of myosin light chain, which induces airway smooth muscle contraction and highlights the importance of paracrine signals from the airway epithelium to the underlying smooth muscle to induce AHR.
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New targets for resolution of airway remodeling in obstructive lung diseases.
TL;DR: This review provides a brief overview of the features and putative mechanisms affecting AR and discusses recently proposed strategies with promise for deterring or treating AR.
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Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation.
Kirsty Meldrum,Kirsty Meldrum,Kirsty Meldrum,Sarah Robertson,Sarah Robertson,Isabella Römer,Isabella Römer,Tim Marczylo,Tim Marczylo,Lareb S. N. Dean,Lareb S. N. Dean,Andrew V. Rogers,Timothy W. Gant,Timothy W. Gant,Rachel Smith,Rachel Smith,Teresa D. Tetley,Teresa D. Tetley,Martin O. Leonard,Martin O. Leonard +19 more
TL;DR: Changes in the expression of genes including CCL20, CXCL10, NLRC5, IRF7 and CLEC10A suggest regulation of dendritic cells, macrophage functionality and IRF3 modulation as key early events in how CeO2NPs may guide pulmonary responses to HDM towards type II inflammation.
Journal ArticleDOI
Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.
Amir A. Al-Khami,Amir A. Al-Khami,Mohamed A. Ghonim,Mohamed A. Ghonim,L. Del Valle,Salome V. Ibba,Liqin Zheng,Kusma Pyakurel,Samuel C. Okpechi,Jone Garay,Dorota Wyczechowska,Maria Dulfary Sanchez-Pino,Paulo C. Rodriguez,A. H. Boulares,Augusto C. Ochoa +14 more
TL;DR: This work has shown that chronic inflammatory conditions such as parasitic infections and cancer trigger a metabolic reprogramming from the preferential use of glucose to the up‐regulation of fatty acid oxidation in myeloid cells, including macrophages and granulocytic and monocytic myelid derived suppressor cells.
Journal ArticleDOI
Single-cell transcriptomic analysis reveals key immune cell phenotypes in the lungs of patients with asthma exacerbation.
Hui Li,Huaqi Wang,Leon A. Sokulsky,Shaoxia Liu,Rui Yang,Xiaojie Liu,Lujia Zhou,Juan Li,Chun Huang,Fangfang Li,Xu Lei,Hongxia Jia,Jiuling Cheng,Fuguang Li,Ming Yang,Ming Yang,Guojun Zhang +16 more
TL;DR: This study identifies a significant number of severe asthma-associated genes that are differentially expressed by multiple cell clusters and identifies therapeutic targets that should be further explored in exacerbation treatments.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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