Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
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Ma Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway.
Jiao Jiayuan,Jiming Wu,Jiali Wang,Ya-Ping Guo,Le Gao,Hong-Gang Liang,Jian Huang,Jin-Hui Wang +7 more
TL;DR: MHT could mitigate the pathological changes of acute asthma-like syndrome through inhibition of the TLR9 pathway and may provide a reference for the development of a novel therapy for patients with allergic asthma.
Journal ArticleDOI
Distal airways are protected from goblet cell metaplasia by diminished expression of IL‐13 signalling components
Christina Vock,A. Ö. Yildirim,Christina Wagner,Schlick S,Lars Lunding,Chun Geun Lee,Jack A. Elias,Heinz Fehrenbach,Michael Wegmann +8 more
TL;DR: Increased mucus production is a critical factor impairing lung function in patients suffering from bronchial asthma, the most common chronic inflammatory lung disease worldwide.
Journal ArticleDOI
Repeated Allergen Exposure in A/J Mice Causes Steroid-Insensitive Asthma via a Defect in Glucocorticoid Receptor Bioavailability.
Magda F. Serra,Amanda C. Cotias,Camila R. R. Pão,Julio Beltrame Daleprane,Patricia Barbosa Jurgilas,Gina C. Couto,Edna A. Anjos-Valotta,Renato S.B. Cordeiro,Vinicius F. Carvalho,Patrícia M.R. e Silva,Marco A. Martins +10 more
TL;DR: It is reported that repeated allergen exposure causes GC-insensitive asthma in A/J mice in a mechanism associated with decrease in GCR availability and subsequent loss of steroid capacity to modulate pivotal regulatory proteins, such as GATA-3, p-p38, MKP-1, and GILZ.
Journal ArticleDOI
Asthma-COPD overlap: current understanding and the utility of experimental models.
Xiaofan Tu,Chantal Donovan,Richard Kim,Richard Kim,Richard Kim,Peter A. B. Wark,Jay C. Horvat,Philip M. Hansbro,Philip M. Hansbro,Philip M. Hansbro +9 more
TL;DR: In this article, the authors review the current understanding of the clinical features of ACO and highlight the approaches that are best suited for developing representative experimental models of the ACO, which will identify underlying disease-causing mechanisms, as well as enabling the identification of novel therapeutic targets and providing a platform for assessing new ACO therapies.
Book ChapterDOI
Autophagy in chronic lung disease.
TL;DR: Recent advances on the role of autophagy in the pathogenesis of asthma, chronic obstructive pulmonary disease and emphysema, pulmonary arterial hypertension, and idiopathic pulmonary fibrosis are highlighted.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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