Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Journal ArticleDOI
The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients.
TL;DR: Treg cells decreased in asthmatic patients, with an impaired immunosupression function and a Th2-like phenotype, which may be due to overexpression of GATA3 and FOXP3, regulated by USP21 and PIM2, respectively.
Journal ArticleDOI
Toll-like receptor 9-dependent interferon production prevents group 2 innate lymphoid cell-driven airway hyperreactivity
TL;DR: TLR9 activation alleviates ILC2-driven AHR and airway inflammation through direct suppression of cell function and Microparticle-based delivery of TLR9 ligands might serve as a therapeutic strategy for asthma treatment.
Journal ArticleDOI
GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation.
TL;DR: It is demonstrated that GM‐CSF signaling, although being largely dispensable for eosinophil development at steady state, intrinsically promotes accumulation of eOSinophils in the lung during allergic airway inflammation.
Journal ArticleDOI
Immunomodulation in pediatric asthma
Amelia Licari,Sara Manti,Riccardo Castagnoli,Alessia Marseglia,Thomas Foiadelli,Ilaria Brambilla,Gian Luigi Marseglia +6 more
TL;DR: The aim of this review is to update knowledge on current and novel therapeutic options targeted to immunomodulate inflammatory pathways underlying pediatric asthma, with particular reference on biologic therapies.
Journal ArticleDOI
Computational analysis of multimorbidity between asthma, eczema and rhinitis
Daniel Aguilar,Mariona Pinart,Gerard H. Koppelman,Yvan Saeys,Martijn C. Nawijn,Dirkje S. Postma,M. Akdis,Charles Auffray,Stephane Ballereau,Marta Benet,Judith Garcia-Aymerich,Juan R. González,Stefano Guerra,Thomas Keil,Manolis Kogevinas,Bart N. Lambrecht,Nathanaël Lemonnier,Erik Melén,Jordi Sunyer,Rudolf Valenta,Sergi Valverde,Magnus Wickman,Jean Bousquet,Jean Bousquet,Baldo Oliva,Josep M. Antó +25 more
TL;DR: Asthma, eczema and rhinitis shared a larger number of associated proteins than expected by chance, and their associated proteins exhibited a significant degree of interconnectedness in the interaction network, suggesting that type 2 signaling pathways represent a relevant multimorbidity mechanism of allergic diseases.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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