Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
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The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma.
Hironori Sadamatsu,Koichiro Takahashi,Hiroki Tashiro,Yuki Kurihara,Go Kato,Masaru Uchida,Yoshihiko Noguchi,Keigo Kurata,Satoshi Ōmura,Toshiaki Sunazuka,Shinya Kimura,Naoko Sueoka-Aragane +11 more
TL;DR: Both type 2 and type 2-low airway inflammation were attenuated by EM900 in this obesity-associated asthma model, and results show that EM900 might be a candidate agent for the treatment of obesity- associated asthma.
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Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.
Nadia Mazarakis,Nadia Mazarakis,Jitraporn Vongsvivut,Keith R. Bambery,Katherine Ververis,Mark J. Tobin,Simon G. Royce,Chrishan S. Samuel,Kenneth J. Snibson,Paul V. Licciardi,Tom C. Karagiannis,Tom C. Karagiannis +11 more
TL;DR: This work examined the effects of several experimental compounds with potential anti-asthmatic effects using both a prevention and reversal model of chronic allergic airways disease and validated the reduction in collagen deposition induced by each experimental compound evaluated.
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Secondhand tobacco smoke and severity in wheezing children: Nasal oxidant stress and inflammation.
TL;DR: Level of nasal or serum inflammatory markers fail to explain secondhand tobacco smoke exposure association with more severe respiratory symptoms in wheezing children, either because of different mechanical factors in the process or due to low levels of the biomarkers especially in nasal secretions.
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Marine Algal Derived Phenolic Compounds and their Biological Activities for Medicinal and Cosmetic Applications
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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