Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
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Sex Steroids Effects on Asthma: A Network Perspective of Immune and Airway Cells
TL;DR: The potential relationship between key elements of the immune cell system and their interplay with sex steroids, relevant to structural cells in the pathophysiology of asthma and many other lung diseases, is illustrated.
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Herbal and Animal Derived Remedies for Obstructive Pulmonary Disease (Asthma and Chronic Obstructive Pulmonary Disease): A Review Study
TL;DR: A review of the existing literature about complementary therapies for asthma and COPD is undertaken and it is found that lack of comprehensive clinical trials aimed on regarded effects still remains to reconfirm the traditional knowledge.
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Immunomodulatory effect of different extracts from Angiostrongylus cantonensis on airway inflammation in an allergic asthma model
Vanessa Fey Pascoal,Aline Andrea da Cunha,Alessandra Loureiro Morassutti,Géssica Luana Antunes,Keila Abreu da Silveira,Josiane Silva Silveira,Nailê Karine Nuñez,Rodrigo Godinho de Souza,Carlos Graeff-Teixeira,Paulo Márcio Pitrez +9 more
TL;DR: This is the first study to reveal that the total soluble extract of A. cantonensis adult worms has a greater potential for developing a novel therapeutic for allergic asthma.
Journal ArticleDOI
Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity.
Yingjiao Cao,Yu Li,Xiangyang Wang,Shaorui Liu,Yong-Mei Zhang,Gao-Yu Liu,Shusen Ye,Yuhao Zheng,Jiacong Zhao,Xiao-Dong Zhu,Ying-ying Chen,Haixu Xu,Ding-Yun Feng,Dubo Chen,Ling Chen,Wangkai Liu,Wenjie Zhou,Zhi Sheng Zhang,Pan Zhou,Kai Deng,Lilin Ye,Ying Yu,Zhi Yao,Qiang Liu,Heping Xu,Jie Zhou +25 more
TL;DR: In this article , the abundance of dopamine was negatively correlated with circulating ILC2 numbers and positively associated with pulmonary function in humans, and local administration of dopamine alleviated allergen-induced ILC 2 responses and airway inflammation.
Journal ArticleDOI
Sialyl Glycan Expression on T Cell Subsets in Asthma: a correlation with disease severity and blood parameters
Yu Liang Yeh,Yu Liang Yeh,Yu Liang Yeh,Wen Chia Wu,Reiji Kannagi,Bor-Luen Chiang,Fu-Tong Liu,Yungling Leo Lee,Yungling Leo Lee +8 more
TL;DR: The study suggests that sialyl glycans on T cells may play important roles in the pathogenesis of asthma, and assessed the relationships between glycan-expressing cell percentages and asthma clinical parameters.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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