Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
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Journal ArticleDOI
Biomarkers and asthma management: analysis and potential applications.
Levi B. Richards,Anne H. Neerincx,Job J.M.H. van Bragt,Peter J. Sterk,Elisabeth H. Bel,Anke H. Maitland-van der Zee +5 more
TL;DR: Individualisation of asthma treatment regimens on the basis of biomarkers is necessary to improve asthma control, however, the suboptimal properties of currently available conventional biomarkers limit its clinical utility.
Journal ArticleDOI
Association between cigarette smoking and interleukin-17A expression in nasal tissues of patients with chronic rhinosinusitis and asthma.
Chien-Chia Huang,Chun Hua Wang,Chia-Hsiang Fu,Chi-Che Huang,Po-Hung Chang,Yi-Wei Chen,Chia-Chen Wu,Pei-Wen Wu,Ta-Jen Lee +8 more
TL;DR: Cigarette smoking was associated with an increase in the number of unexpected emergency clinic visits due to acute asthma attack and in the expression of IL-17A in the nasal tissues of patients with airway inflammatory diseases.
Journal ArticleDOI
Obesity's effect on asthma extends to diagnostic criteria.
Njira L Lugogo,Cynthia L. Green,Noah Agada,Siyi Zhang,Susanne Meghdadpour,Run Zhou,Siyun Yang,Kevin J. Anstrom,Elliot Israel,Richard J. Martin,Robert F. Lemanske,Homer A. Boushey,Stephen C. Lazarus,Stephen I. Wasserman,Mario Castro,William J. Calhoun,Stephen P. Peters,Emily DiMango,Vernon M. Chinchilli,Susan J. Kunselman,Tonya S. King,Nikolina Icitovic,Monica Kraft +22 more
TL;DR: In obese asthmatic subjects conventional biomarkers of inflammation are poorly predictive of eosinophilic airway inflammation, and biomarkers currently used to delineate eos inophilic inflammation should be approached with caution in these subjects.
Journal ArticleDOI
Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation
Elizabeth A. Jacobsen,Sergei I. Ochkur,Alfred D. Doyle,William E. LeSuer,Wen Li,Cheryl A. Protheroe,Dana Colbert,Katie R. Zellner,H.H. Shen,Charles G. Irvin,James J. Lee,Nancy A. Lee +11 more
TL;DR: Improvements observed in patients with asthma responding to therapeutic strategies ablating eosinophils may occur as a consequence of targeting immunoregulatory mechanisms and not by simply eliminating the destructive activities of these purportedly end‐stage effector cells.
Journal ArticleDOI
Mimicking Antigen-Driven Asthma in Rodent Models-How Close Can We Get?
Francesca Alessandrini,Stephanie Musiol,Evelyn Schneider,Frank Blanco-Pérez,Melanie Albrecht +4 more
TL;DR: The employment of genetically modified animals, which provide an in-depth understanding of the role of a variety of molecules, signaling pathways and receptors implicated in the development of this disease as well as humanized models of allergic inflammation, which have been recently developed to overcome differences between the rodent and human immune systems are discussed.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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