Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Polymorphonuclear myeloid-derived suppressor cells attenuate allergic airway inflammation by negatively regulating group 2 innate lymphoid cells.
Yingjiao Cao,Yumei He,Xiangyang Wang,Yongdong Liu,Kun Shi,Zheng Zheng,Xue Su,Aihua Lei,Juan He,Jie Zhou +9 more
TL;DR: The findings demonstrated that PMN‐MDSCs may serve as a potent therapeutic target for the treatment of ILC2‐driven allergic asthma, and showed that cyclo‐oxygenase‐1 may mediate the suppressive effects of PMN'SDSCs on I LC2 responses.
Journal ArticleDOI
Modulation of the IL-23/IL-17 axis by fenofibrate ameliorates the ovalbumin/lipopolysaccharide-induced airway inflammation and bronchial asthma in rats
TL;DR: The suppression of IL-23/IL-17 axis could be considered a molecular therapeutic target for fenofibrate in OVA/LPS-induced airway inflammation and bronchial asthma.
Journal ArticleDOI
Eosinophil diversity in asthma
Glenn Van Hulst,Hashini Maneesha Batugedara,Joseph Jorssen,Renaud Louis,Fabrice Bureau,Christophe Desmet +5 more
TL;DR: Pre-clinical and clinical evidence is explored that suggests the existence of eosinophil subsets with potentially distinct functional roles in asthma, and state-of-the-art strategies for deciphering heterogeneity of this complex cell type are discussed.
Iconography : Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by IL-33
Chloé Michaudel,Claire Mackowiak,Isabelle Maillet,Louis Fauconnier,Cezmi A. Akdis,Milena Sokolowska,Anita Dreher,Hern-Tze Tina Tan,Valerie Quesniaux,Bernhard Ryffel,Dieudonnée Togbe +10 more
TL;DR: It is demonstrated that ozone causes an immediate barrier injury that precedes myeloid cell–mediated inflammatory injury under the control of the IL‐33/ST2 axis, which is critical for maintenance of intact epithelial barrier and inflammation.
Journal ArticleDOI
Ovalbumin-sensitized mice have altered airway inflammation to agriculture organic dust.
Kristi J. Warren,John D. Dickinson,Amy Nelson,Todd A. Wyatt,Todd A. Wyatt,Debra J. Romberger,Debra J. Romberger,Jill A. Poole +7 more
TL;DR: Collectively, ODE increased airway inflammatory cells and chemotactic mediator release in allergic (OVA) sensitized mice to suggest that persons with allergy/asthma be identified and warned prior to the occupational exposure of potentially worsening airway disease.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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