Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects
TL;DR: In this article , the authors used liquid chromatography-mass spectrometry (LCS) to quantify lipid mediators in the nasal airway epithelium and characterize preliminary associations with asthma.
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Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model
Jack Yang,Cornelis van 't Veer,Joris J. T. H. Roelofs,Jeroen W. J. van Heijst,Alex F. de Vos,Keith R. McCrae,Alexey S. Revenko,Jeff Crosby,Tom van der Poll +8 more
TL;DR: It is suggested that kininogen could contribute to HDM-induced rise in Penh independently of allergic lung inflammation and further research is warranted to confirm these data using invasive measurements of airway responsiveness.
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Resolved Influenza A Virus Infection Has Extended Effects on Lung Homeostasis and Attenuates Allergic Airway Inflammation in a Mouse Model.
Qingyu Wu,Ilka Jorde,Olivia Kershaw,Andreas Jeron,Dunja Bruder,Jens Schreiber,Sabine Stegemann-Koniszewski +6 more
TL;DR: IAV has exceptional persisting effects on respiratory immunity with substantial consequences for subsequently induced AAI, including morphological changes, respiratory leukocytes and lymphocytes as well as the pro-inflammatory cytokine responses, which was clearly diminished.
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Asthmatics with concordant eosinophilic disease classified according to their serum IgE status.
Sara Gerday,Florence Schleich,Monique Henket,Françoise Guissard,Virginie Paulus,Renaud Louis +5 more
TL;DR: The more severe airway eosinophilic inflammation in IgE-low non-atopic concordant eosInophilic asthma despite similar treatment with ICS and a higher burden of OCS points to a certain corticosteroid resistance in this asthma phenotype.
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Exosomes in respiratory disease
TL;DR: Recent advances in exosomes have fulfilled their promise as diagnostic biomarkers, enabling noninvasive clinical diagnosis in addition to their use as therapeutic tools, with focuses on pulmonary diseases.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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