Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder.
Ryan W.Y. Lee,Ryan W.Y. Lee,Michael J. Corley,Alina Pang,Gaye Arakaki,Lisa Abbott,Michael Nishimoto,Rob Miyamoto,Erica Lee,Susan Yamamoto,Alika K. Maunakea,Annette Lum-Jones,Miki Wong +12 more
TL;DR: A modified gluten-free ketogenic diet with supplemental MCT is a potentially beneficial treatment option to improve the core features of autism spectrum disorder and warrants further investigation.
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CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease.
Gregory P. Williams,Aubrey M Schonhoff,Asta Jurkuvenaite,Nicole J Gallups,David G. Standaert,Ashley S. Harms +5 more
TL;DR: In this paper, the authors found that α-synuclein overexpression in the midbrain of mice leads to the upregulation of the major histocompatibility complex II (MHCII) protein on CNS myeloid cells as well as the infiltration of IFNγ producing CD4 and CD8 T cells into the CNS.
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Locally instructed CXCR4(hi) neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps
Coraline Radermecker,Catherine Sabatel,Céline Vanwinge,Cecilia Ruscitti,Pauline Maréchal,Fabienne Perin,Joey Schyns,Natacha Rocks,Marie Toussaint,Marie Toussaint,Didier Cataldo,Sebastian L. Johnston,Sebastian L. Johnston,Sebastian L. Johnston,Fabrice Bureau,Thomas Marichal +15 more
TL;DR: It is shown that lung neutrophils in mice exposed to three distinct pro-allergic conditions release neutrophil extracellular traps that potentiate allergen uptake by dendritic cells and type 2 allergic inflammation.
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Benralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma.
Corrado Pelaia,Cecilia Calabrese,Alessandro Vatrella,Maria Teresa Busceti,Eugenio Garofalo,Nicola Lombardo,Rosa Terracciano,Girolamo Pelaia +7 more
TL;DR: The anti-IL-5 monoclonal antibodies mepolizumab and resl Lizumab have been developed and approved for biological therapy of uncontrolled eosinophilic asthma and the anti- IL-5 receptor benralizumAB has also recently obtained the approval from US Food and Drug Administration.
Journal ArticleDOI
Japanese guidelines for adult asthma 2020
Yoichi Nakamura,Jun Tamaoki,Hiroyuki Nagase,Masao Yamaguchi,Takahiko Horiguchi,Soichiro Hozawa,Masakazu Ichinose,Takashi Iwanaga,Rieko Kondo,Makoto Nagata,Akihito Yokoyama,Yuji Tohda +11 more
TL;DR: Inhaled β2-agonists, aminophylline, corticosteroids, adrenaline, oxygen therapy, and other approaches are used as needed during acute exacerbations, by selecting treatment steps for asthma based on the severity of the exacerbations.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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