Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Journal ArticleDOI
Promises and challenges of biologics for severe asthma.
TL;DR: An overview of treatment with the current biologics for severe asthma is provided and the limitations, challenges and unmet needs in clinical management are highlighted.
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Interleukin-33 in the developing lung-Roles in asthma and infection.
TL;DR: The evidence for IL‐33 in the development of immune responses in the lung is focused on, including the role of IL‐ 33–responsive immune cells that may explain susceptibility to allergic sensitization at a young age and the association between genetic variants of IL-33 and asthma in humans.
Journal ArticleDOI
IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors.
Leonardo Cristinziano,Leonardo Cristinziano,Remo Poto,Remo Poto,Gjada Criscuolo,Gjada Criscuolo,Anne Lise Ferrara,Anne Lise Ferrara,Anne Lise Ferrara,Maria Rosaria Galdiero,Luca Modestino,Luca Modestino,Stefania Loffredo,Amato de Paulis,Amato de Paulis,Gianni Marone,Giuseppe Spadaro,Giuseppe Spadaro,Gilda Varricchi +18 more
TL;DR: In this article, the authors investigated whether immunoglobulin superantigens protein A and protein L and IL-33 caused the release of inflammatory (histamine), angiogenic (VEGF-A) and lymphangiogenic factors from HLMCs.
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Imaging Pulmonary Inflammation
TL;DR: The clinical techniques used to image lung inflammation are reviewed, an overview of clinical and emerging PET techniques for quantifying lung inflammation, and potential clinical applications are discussed.
Journal ArticleDOI
Group 2 Innate Lymphoid Cells in Human Respiratory Disorders.
Esmee K. van der Ploeg,Ana Carreras Mascaro,Danny Huylebroeck,Rudi W. Hendriks,Ralph Stadhouders +4 more
TL;DR: Current understanding of human ILC2 biology is summarized and a role for I LC2s in several diseases of the human respiratory system is supported, including their potential involvement in various human respiratory disorders.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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