Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
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TLDR
Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.Abstract:
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.read more
Citations
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Journal ArticleDOI
Prediction of response to biological treatment with monoclonal antibodies in severe asthma.
TL;DR: This review summarizes the results from studies on predicting responses and responders to biological treatment in severe asthma, taking into account clinical, functional and inflammatory parameters assessed prior to the start of treatment as well as following a few months of therapy.
Regulation of group 2 innate lymphoid cells
TL;DR: Current knowledge about positive and negative regulation of ILC2 is summarized, its immunological consequences are discussed and which mediators activate or inhibit this rare but important cell population are discussed.
Journal ArticleDOI
A bispecific antibody strategy to target multiple type 2 cytokines in asthma
Marie Godar,Kim Deswarte,Karl Vergote,Michael A. Saunders,Hans de Haard,Hamida Hammad,Christophe Blanchetot,Bart N. Lambrecht,Bart N. Lambrecht +8 more
TL;DR: In this article, a llama-based antibody platform was used to generate bispecific antibodies that target multiple cytokine signaling pathways as superior inhibitors of asthma features, including the difficult-to-treat GCM.
Journal ArticleDOI
An Update on Lymphocyte Subtypes in Asthma and Airway Disease
TL;DR: In this review, the importance of different lymphocyte subsets to asthma and other airway diseases are discussed, while highlighting the growing evidence that asthma is a syndrome that incorporates many immune phenotypes.
Journal ArticleDOI
Acute Severe Asthma in Adolescent and Adult Patients: Current Perspectives on Assessment and Management.
Eirini Kostakou,Evangelos Kaniaris,Effrosyni Filiou,Ioannis Vasileiadis,Paraskevi Katsaounou,Eleni G. Tzortzaki,Nikolaos Koulouris,Antonia Koutsoukou,Nikoletta Rovina +8 more
TL;DR: Current aspects on the pathogenesis and pathophysiology of acute severe asthma exacerbations are discussed and the current perspectives on the management of acutesevere asthma attacks in the emergency department and the intensive care unit are provided.
References
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Eosinophilic inflammation in asthma.
Jean Bousquet,Pascal Chanez,J.-Y. Lacoste,G. Barneon,N Ghavanian,I. Enander,Per Venge,Staffan Ahlstedt,J Simony-Lafontaine,P. Godard +9 more
TL;DR: Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
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