The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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TLDR
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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Opportunistic pathogens and elements of the resistome that are common in bottled mineral water support the need for continuous surveillance.
Maria Fernanda Falcone-Dias,Daniela Centrón,Fernando Rogério Pavan,Adriana Candido da Silva Moura,Felipe Gomes Naveca,Victor Costa de Souza,Adalberto Farache Filho,Clarice Queico Fujimura Leite +7 more
TL;DR: Differences concerning bacterial species, opportunistic pathogens, elements of the resistome as well as variations concerning the CFU/mL counts were identified in some of the five most marketed bottled mineral water from Araraquara city, São Paulo, Brazil.
Journal ArticleDOI
Antibiotic Resistance in Wastewater Treatment Plants and Transmission Risks for Employees and Residents: The Concept of the AWARE Study
Laura Wengenroth,Fanny Berglund,Hetty Blaak,Mariana Carmen Chifiriuc,Carl-Fredrik Flach,Gratiela Gradisteanu Pircalabioru,D. G. Joakim Larsson,Luminita Marutescu,Mark W J van Passel,Marcela Popa,Katja Radon,Ana Maria de Roda Husman,Daloha Rodríguez-Molina,Tobias Weinmann,Andreas Wieser,Heike Schmitt +15 more
TL;DR: The AWARE (Antibiotic Resistance in Wastewater: Transmission Risks for Employees and Residents around Wastewater Treatment Plants) study as discussed by the authors investigates the potential spread of ESBL-producing E. coli, carbapenemase-producing Enterobacteriaceae, and antibiotic resistance genes from WWTPs to workers, the environment, and nearby residents.
Journal ArticleDOI
Distinct aggregate stratification of antibiotic resistome in farmland soil with long-term manure application.
TL;DR: In this paper , the authors examined the patterns of antibiotic resistome distribution among differently sized soil aggregates using high-throughput quantitative polymerase chain reaction (HT-qPCR) and showed that the distribution of soil ARGs could be affected by manure application and aggregate size individually but not interactively.
Journal Article
Multiple antibiotic resistant index and detection of qnrS and qnrB genes in bacterial consortium of urine samples from clinical settings
TL;DR: The presence of resistant genes in ciprofloxacin-resistant P. aeruginosa and quinolone-resistant E. faecalis in urine samples further emphasized the need for the regulation of over-the-counter prescription and antibiotic susceptibility survey of anti-pseudomonal and anti-enterococcal quinlones in hospital settings.
Journal ArticleDOI
Simultaneous Removal of Antibiotics and Heavy Metals with Poly(Aspartic Acid)-Based Fenton Micromotors
TL;DR: In this paper, a multifunctional micromotor was proposed to implement the adsorption and degradation roles simultaneously by integrating the poly(aspartic acid) (PASP) adsorbent with a MnO2-based catalyst.
References
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Antibiotics and antibiotic resistance in water environments
TL;DR: Methods to reduce resistant bacterial load in wastewaters, and the amount of antimicrobial agents, in most cases originated in hospitals and farms, include optimization of disinfection procedures and management of wastewater and manure.