The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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TLDR
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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Co-selection of antibiotic and metal(loid) resistance in gram-negative epiphytic bacteria from contaminated salt marshes.
Isabel Henriques,Marta Tacão,Laura Rabelo Leite,Cátia Fidalgo,Susana Araújo,Cláudia S. Oliveira,Artur Alves +6 more
TL;DR: Results indicate that metal(loid) contamination selects for antibiotic resistance in plant surfaces in salt marshes, and differences among sites were not observed in terms of prevalence or diversity of acquired antibiotic resistance genes, integrons and plasmids.
Journal ArticleDOI
Critical evaluation of short, long, and hybrid assembly for contextual analysis of antibiotic resistance genes in complex environmental metagenomes
TL;DR: In this paper, the authors evaluate the impact of assembly leveraging short reads, nanopore MinION long-reads, and a combination of the two (hybrid) on ARG contextualization for ten environmental metagenomes using seven prominent assemblers.
Journal ArticleDOI
The global challenge of new classes of antibacterial agents: an industry perspective
TL;DR: Suggestions are provided to overcome each of the hurdles faced by antibiotic developers in order to prevent the antibiotic pipeline from running dry.
Journal ArticleDOI
Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage
Jumpei Uchiyama,Iyo Takemura-Uchiyama,Yoshihiko Sakaguchi,Keiji Gamoh,Shin-ichiro Kato,Masanori Daibata,Takako Ujihara,Naoaki Misawa,Shigenobu Matsuzaki +8 more
TL;DR: This is the first report of successful intragenus generalized transduction among staphylococci, and phage S6 was a novel type of giant myophage, which possessed a DNA genome that contained uracil instead of thymine, and it could infect all of the tested stAPHylococcal species.
Initiatives for Addressing Antimicrobial Resistance in the Environment - Current Situation and Challenges
Z Ahammad,M Arduino,de, Roda, Husman, Am,Lisa M. Durso,T Edge,G Garber,J Garland,W Gaze,W Gaze,David W. Graham,A Kirby,T LaPara,J McLain,C McDonald,S Nappier,D Patrick,Emily K. Rousham,D Stekel,Edward Topp,D Verner-Jeffreys,Thomas E. Wittum,A Wong +21 more
References
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Antibiotics and antibiotic resistance in water environments
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