The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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TLDR
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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Environmental risk assessment of antibiotics in agroecosystems: ecotoxicological effects on aquatic microbial communities and dissemination of antimicrobial resistances and antibiotic biodegradation potential along the soil-water continuum.
Fabrice Martin-Laurent,Edward Topp,Loren Billet,Isabelle Batisson,Cédric Malandain,Pascale Besse-Hoggan,Soizic Morin,Joan Artigas,Chloé Bonnineau,Laura Kergoat,Marion Devers-Lamrani,Stéphane Pesce +11 more
TL;DR: The ANTIBIOTOX project aims at studying the environmental fate and impact of two antibiotics of the sulfonamide class of antibiotics, sulfamethazine (SMZ), and sulfamETHoxazole (SMX), which have a wide application range in human and veterinary medicines.
Journal ArticleDOI
Enhanced antibacterial activity and mechanism studies of Ag/Bi2O3 nanocomposites
TL;DR: In this paper, a sphere-like Ag/Bi 2 O 3 nanocomposites with the average size of 170 nm were successfully synthesized by simple deposition-precipitation method.
Journal ArticleDOI
Policy options for reducing antibiotics and antibiotic-resistant genes in the environment.
Ellen Bloomer,Martin McKee +1 more
TL;DR: The evidence on the role of agriculture, aquaculture, domestic waste and pharmaceutical manufacturing in the spread of antibiotic resistance is reviewed, concluding that all of these activities pose a potentially serious threat.
Journal ArticleDOI
Multidrug resistant Pseudomonas aeruginosa survey in a stream receiving effluents from ineffective wastewater hospital plants.
Mary Joyce Targino Lopes Magalhães,Gemilson Soares Pontes,Paula Takita Serra,Antônio Alcirley da Silva Balieiro,Diogo Pereira de Castro,Fábio Alessandro Pieri,James Lee Crainey,Paulo Nogueira,Patrícia Puccinelli Orlandi +8 more
TL;DR: Results show that a diverse range of MDRPA are being discharged in an urban stream from a HWWTP in Manaus and that P. aeruginosa strains with ampicillin and amikacin can persist well within it.
Journal ArticleDOI
Extended-Spectrum β-Lactamase, AmpC, and MBL-Producing Gram-Negative Bacteria on Fresh Vegetables and Ready-to-Eat Salads Sold in Local Markets.
TL;DR: The study has demonstrated the occurrence and distribution of ESBL/AmpC and MBL strains in fresh vegetables and RTE salads in Italy and possible public health risks associated with consumption of these fresh products.
References
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Journal ArticleDOI
Antibiotic resistance is ancient
Vanessa M. D'Costa,Christine E. King,Lindsay Kalan,Mariya Morar,Wilson W L Sung,Carsten Schwarz,Duane G. Froese,Grant D. Zazula,Fabrice Calmels,Régis Debruyne,G. Brian Golding,Hendrik N. Poinar,Gerard D. Wright +12 more
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BookDOI
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Journal ArticleDOI
Antibiotics and antibiotic resistance in water environments
TL;DR: Methods to reduce resistant bacterial load in wastewaters, and the amount of antimicrobial agents, in most cases originated in hospitals and farms, include optimization of disinfection procedures and management of wastewater and manure.