The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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TLDR
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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Fecal Indicator Bacteria and Antibiotic Resistance Genes in Storm Runoff from Dairy Manure and Compost-Amended Vegetable Plots.
TL;DR: Findings indicate that agricultural fields receiving manure-derived amendments release higher quantities of these two "indicator" ARGs in runoff, particularly during the early stages of the growing season, and that composting did not reduce effects of ARG loading in runoff.
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Quantitative proteome analysis of an antibiotic resistant Escherichia coli exposed to tetracycline reveals multiple affected metabolic and peptidoglycan processes
Daniela Jones-Dias,Ana Sofia Carvalho,Ines B Moura,Vera Manageiro,Gilberto Igrejas,Manuela Caniça,Rune Matthiesen +6 more
TL;DR: The proteome profiling of a soil-borne Escherichia coli upon tetracycline stress is reported so that this new perspective could provide a broaden understanding of the metabolic responses of E. coli to a widely used antibiotic.
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Tetracycline uptake and metabolism by vetiver grass (Chrysopogon zizanioides L. Nash)
Aparupa Sengupta,Dibyendu Sarkar,Padmini Das,Saumik Panja,Chinmayi Parikh,Dilrukshi Ramanathan,Susan T. Bagley,Rupali Datta +7 more
TL;DR: Metabolic profiling revealed that glyoxylate metabolism, TCA cycle, biosynthesis of secondary metabolites, tryptophan metabolism, and inositol phosphate metabolism were impacted in vetiver root by TC treatment.
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A closer look at the antibiotic-resistant bacterial community found in urban wastewater treatment systems
TL;DR: Investigation of the occurrence of antibiotic resistance in three wastewater treatment plants found that bacteria resistant to tetracycline were more likely to display resistance to multiple antibiotics compared to those isolates that were not tetrACYcline resistant.
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Dissemination of antibiotic resistance genes, mobile genetic elements, and efflux genes in anthropogenically impacted riverine environments.
Preeti Chaturvedi,Preeti Chaturvedi,Pankaj Chowdhary,Anuradha Singh,Deepshi Chaurasia,Ashok Pandey,Ram Chandra,Pratima Gupta +7 more
TL;DR: In this article, a study aimed at MDR, ESBL, AmpC, efflux genes, and heavy metals resistance genes (HMRGs) in bacterial isolates from four Indian rivers belonging to different geo-climatic zones, by estimating the mode of resistance transmission exhibited by the resistant isolates.
References
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Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Helen W. Boucher,George H. Talbot,John S. Bradley,John S. Bradley,John E. Edwards,John E. Edwards,David N. Gilbert,Louis B. Rice,Louis B. Rice,Michael Scheld,Brad Spellberg,Brad Spellberg,John G. Bartlett +12 more
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Antibiotics in the aquatic environment - A review - Part II
TL;DR: This review brings up important questions that are still open, and addresses some significant issues which must be tackled in the future for a better understanding of the behavior of antibiotics in the environment, as well as the risks associated with their occurrence.
Journal ArticleDOI
Antibiotic resistance is ancient
Vanessa M. D'Costa,Christine E. King,Lindsay Kalan,Mariya Morar,Wilson W L Sung,Carsten Schwarz,Duane G. Froese,Grant D. Zazula,Fabrice Calmels,Régis Debruyne,G. Brian Golding,Hendrik N. Poinar,Gerard D. Wright +12 more
TL;DR: Target metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments are reported and show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
BookDOI
Water for Food Water for Life : A Comprehensive Assessment of Water Management in Agriculture
TL;DR: Molden et al. as discussed by the authors presented a comprehensive assessment of water management in agriculture, focusing on water for food, water for life, and water for the future of agriculture.
Journal ArticleDOI
Antibiotics and antibiotic resistance in water environments
TL;DR: Methods to reduce resistant bacterial load in wastewaters, and the amount of antimicrobial agents, in most cases originated in hospitals and farms, include optimization of disinfection procedures and management of wastewater and manure.