The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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TLDR
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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Influence of ionizing radiation on the antimicrobial activity of the antibiotics sulfamethoxazole and trimethoprim.
Gyuri Sági,K. Szabacsi,László Szabó,Renáta Homlok,Krisztina J. Kovács,Csilla Mohácsi-Farkas,Suresh D. Pillai,Erzsébet Takács,László Wojnárovits +8 more
TL;DR: The results imply that the synergistic antimicrobial activity of antimicrobial compounds in pharmaceutical waste streams is a strong possibility and should be included when evaluating the use of ionizing radiation technology for the remediation of pharmaceutical or municipal waste streams.
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Role for risk-scoring tools in identifying resistant pathogens in pneumonia: reassessing the value of healthcare-associated pneumonia as a concept.
TL;DR: Physicians should consider adopting risk-scoring tools to stratify patients as to the likelihood that their infection is caused by a pathogen such as methicillin-resistant S. aureus or P. aeruginosa, which provide more precision at correctly segregating patients on the basis of the eventual recovery of resistant bacteria than does the HCAP syndrome.
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Antimicrobial resistance of Staphylococcus aureus, fecal streptococci, Enterobacteriaceae and Pseudomonas aeruginosa isolated from the coastal water of the Gaza strip-Palestine
A Elmanama Abdelraouf,Hartemann Philippe,J Elnabris Kamal,Ayesh Adnan,Afifi Samir,Elfara Fatma,R Aljubb Alaa +6 more
TL;DR: It is demonstrated that the seawater of the Gaza strip is highly contaminated with antibiotic resistant bacteria which can be transmitted to humans through recreational and other activities and there is a need to apply appropriate and rationale use of antibiotic to minimize the occurrence of multiple antibiotics resistant bacteria in the marine environment.
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Assessment on impact of sewage in coastal pollution and distribution of fecal pathogenic bacteria with reference to antibiotic resistance in the coastal area of Cape Comorin, India
TL;DR: In this article , a bacteriological survey was made on distribution and abundance of fecal indicators and human pathogenic bacteria and seasonal influence on the bacterial load and antibiotic resistance of the isolates.
Journal ArticleDOI
Molecular identification, in vitro copper resistance and antibiotics susceptibility of the causal agent of the olive knot disease in Morocco
Bouaichi Abdelaaziz,L. Hanane,O. Mohamed,K. Imad,H. Khaoula,B. Abdellatif,B. Rachid,A. El hassan +7 more
TL;DR: The alkaline method for the DNA extraction from pure culture was reliable and rapid and can be recommended for molecular detection the causal agent of the olive knot.
References
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Antibiotics and antibiotic resistance in water environments
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