The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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TLDR
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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Human Monoclonal Antibodies as a New Class of Antiinfective Compounds
TL;DR: The microbial ability of using “magic tricks” against therapeutic compounds, that is, of developing resistance mechanisms, is true for all groups of pathogens and all classes of antiinfective drugs, making the need of reliable alternatives everyday more compelling.
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BioF is a novel B2 metallo-β-lactamase from Pseudomonas sp. isolated from an on-farm biopurification system.
Juan Hilario Cafiero,María Carla Martini,Mauricio Javier Lozano,Carolina Vacca,Antonio Lagares,Pablo E. Tomatis,Pablo E. Tomatis,María Florencia Del Papa +7 more
TL;DR: In this article, a new subclass B2 MBL was identified in a new environmental Pseudomonas sp. strain isolated from an on-farm biopurification system (BPS).
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The Use of Compost Tea in a Containerized Urban Tree Nursery Shows No Evident Benefits to Tree Growth or Mycorrhizal Colonization
TL;DR: In this paper , the effects of compost tea application on tree growth and root mycorrhizal colonization over six months were investigated for containerized urban tree species (Acer negundo, Corymbia maculata, Ficus platypoda, Hymenosporum flavum, Jacaranda mimosifolia).
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Application of earthworm and silicon can alleviate antibiotic resistance in soil-Chinese cabbage system with ARGs contamination.
Zufei Xiao,Ruixia Han,Jianqiang Su,Zheng-qing Zhu,Yi Zhao,Qing-Lin Chen,Junyi Zhao,Gang Li,Yong-Guan Zhu +8 more
TL;DR: In this paper , the effect of different amendment strategies (earthworm and/or silicon) and the related influencing factors on the alleviation of ARGs using high-throughput qPCR was explored.
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Quality of dialysis water and dialysate in haemodialysis centres: Highlight for occurrence of non‐fermenting gram‐negative bacilli
Laís Anversa,C. D. Romani,Eliane S. Caria,Erika Kushikawa Saeki,Gabriel Antonio Nogueira Nascentes,Maricene Garbelotti,Regina Célia Arantes Stancari,Stéfani Thais Alves Dantas,Vera Lm Rall,Luciana S. Ruiz,Carlos Henrique Camargo,Virgínia Bodelão Richini-Pereira +11 more
TL;DR: To evaluate the physicochemical and microbiological quality of dialysis water and dialysate samples from haemodialysis centres, data is collected from eight dialysis centres in the period of May 21 to 29, 2009.
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