The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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TLDR
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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Inequality and antibiotic resistance: A contractualist perspective.
TL;DR: The justification of relevant inequalities from a contractualist perspective is focused on the distribution of antibiotic benefits and burdens in the developing world.
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<i>Salmonella</i> Typhimurium ST34 Isolate Was More Resistant than the ST19 Isolate in China, 2007 − 2019
TL;DR: Wang et al. as discussed by the authors analyzed the antimicrobial susceptibility and wide adaptability of commonly occurring genotypes of Salmonella enterica serovar Typhimurium, and found that 66.8% of the isolates were multidrug-resistant (MDR) strains, with resistance to three or more antimicrobials.
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Salmonella Typhimurium ST34 Isolate Was More Resistant than the ST19 Isolate in China, 2007 - 2019.
Kai Zhang,Danièle Lamarque,Haojie Ge,Jingjing He,Maozhi Hu,Zhengzhong Xu,Xinan Jiao,Xiang Chen +7 more
TL;DR: In this paper, the antimicrobial susceptibility and wide adaptability of commonly occurring genotypes of Salmonella enterica serovar Typhimurium, as well as antimicrobial resistance and multilocus sequence t...
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Tagging the vanA gene in wastewater microbial communities for cell sorting and taxonomy of vanA carrying cells
TL;DR: Although further efforts are needed to overcome technical problems, this study has, for the first time, demonstrated sorting bacterial-cells carrying antibiotic resistance genes from wastewater samples through a TSA-FISH-FACS protocol and provided insight into the microbial ecology of vancomycin resistant bacteria.
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Genomic and Chemical Decryption of the Bacteroidetes Phylum for Its Potential to Biosynthesize Natural Products
TL;DR: The development of pipelines for anti-infectives to be applied in plant, animal, and human health management are dried up as mentioned in this paper , as resistance development against compounds in use calls for new lead structures.
References
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Antibiotic resistance is ancient
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Antibiotics and antibiotic resistance in water environments
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