The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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TLDR
The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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A critical review on the antimicrobial resistance, antibiotic residue and metagenomics-assisted antimicrobial resistance gene detection in freshwater aquaculture environment
Hemamalini Nallaiah,Shanmugam Seerappalli Aran,Kathirvelpandian Ayyathurai,Deepak Agarwal,Kaliyamurthi Venkatachalam,Suresh Eswaran +5 more
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Ceftiofur-resistant Salmonella enterica serovar Heidelberg of poultry origin – a risk profile using the Codex framework
Carolee A. Carson,Xian-Zhi Li,Agnes Agunos,Daleen Loest,Brennan Chapman,Rita Finley,Manisha Mehrotra,Lauren M. Sherk,Réjean Gaumond,Rebecca Irwin +9 more
TL;DR: The Codex Guidelines provided a useful approach to summarise data for decision-makers to evaluate an AMR food safety issue, and the evidence was sufficient to indicate the need for risk management options, such as restricting the use of ceftiofur in poultry.
Journal ArticleDOI
MALDI-TOF MS Identification and Clustering Applied to Enterobacter Species in Nosocomial Setting.
Lucia Florio,Elisabetta Riva,Annalisa Giona,Etleva Dedej,Marta Fogolari,Eleonora Cella,Silvia Spoto,Alessia Lai,Gianguglielmo Zehender,Massimo Ciccozzi,Silvia Angeletti +10 more
TL;DR: The relative numbers of Enterobacter species, their antimicrobial susceptibility along 3 years of observation and the identification ability of the two most common MALDI-TOF platforms were evaluated to identify changes in the microbial population within the nosocomial environment.
Journal ArticleDOI
Low-cost, flexible, disinfectant-free and regular-array three-dimensional nanopyramid antibacterial films for clinical applications
Kwong Hoi Tsui,Xin Li,Xin Li,James K.H. Tsoi,Siu-Fung Leung,Tang Lei,Wing Yi Chak,Chengfei Zhang,Jiang Chen,Gary S.P. Cheung,Zhiyong Fan +10 more
TL;DR: A low-cost, scalable and highly repeatable approach was developed to prepare polystyrene films with three-dimensional nanopyramids on the surface that showed an excellent antibacterial performance with more than 90% reduction in the E. coli population after a 168 h prolonged incubation time.
Journal ArticleDOI
Manure Compost Is a Potential Source of Tetracycline-Resistant Escherichia coli and Tetracycline Resistance Genes in Japanese Farms.
Nobuki Yoshizawa,Masaru Usui,Akira Fukuda,Tetsuo Asai,Hidetoshi Higuchi,Eiryu Okamoto,Kanako Seki,Hideshige Takada,Yutaka Tamura +8 more
TL;DR: The results suggest that the use of antimicrobials in livestock constitutes a selective pressure, not only in livestock feces but also in manure compost, for avoiding the spread of ARB and ARGs.
References
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Journal ArticleDOI
Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America
Helen W. Boucher,George H. Talbot,John S. Bradley,John S. Bradley,John E. Edwards,John E. Edwards,David N. Gilbert,Louis B. Rice,Louis B. Rice,Michael Scheld,Brad Spellberg,Brad Spellberg,John G. Bartlett +12 more
TL;DR: An update on potentially effective antibacterial drugs in the late-stage development pipeline is provided, in the hope of encouraging collaboration between industry, academia, the National Institutes of Health, the Food and Drug Administration, and the Centers for Disease Control and Prevention work productively together.
Journal ArticleDOI
Antibiotics in the aquatic environment - A review - Part II
TL;DR: This review brings up important questions that are still open, and addresses some significant issues which must be tackled in the future for a better understanding of the behavior of antibiotics in the environment, as well as the risks associated with their occurrence.
Journal ArticleDOI
Antibiotic resistance is ancient
Vanessa M. D'Costa,Christine E. King,Lindsay Kalan,Mariya Morar,Wilson W L Sung,Carsten Schwarz,Duane G. Froese,Grant D. Zazula,Fabrice Calmels,Régis Debruyne,G. Brian Golding,Hendrik N. Poinar,Gerard D. Wright +12 more
TL;DR: Target metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments are reported and show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
BookDOI
Water for Food Water for Life : A Comprehensive Assessment of Water Management in Agriculture
TL;DR: Molden et al. as discussed by the authors presented a comprehensive assessment of water management in agriculture, focusing on water for food, water for life, and water for the future of agriculture.
Journal ArticleDOI
Antibiotics and antibiotic resistance in water environments
TL;DR: Methods to reduce resistant bacterial load in wastewaters, and the amount of antimicrobial agents, in most cases originated in hospitals and farms, include optimization of disinfection procedures and management of wastewater and manure.