The Scourge of Antibiotic Resistance: The Important Role of the Environment
Rita Finley,Peter Collignon,D. G. Joakim Larsson,Scott A. McEwen,Xian-Zhi Li,William H. Gaze,Richard J. Reid-Smith,Mohammed Timinouni,David W. Graham,Edward Topp +9 more
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The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome, which highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management.Abstract:
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.read more
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Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration.
TL;DR: The minimal selective concentrations (MSCs) for macrolide and fluoroquinolone antibiotics included on the European Commissionʼs Water Framework Directive’s priority hazardous substances Watch List were determined and differential rates of negative selection were associated with elevated prevalence relative to the no antibiotic control below the MSC.
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Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission.
Dae-Wi Kim,Chang-Jun Cha +1 more
TL;DR: In this paper, the authors describe the previously established concept of the resistome, which encompasses all types of antibiotic resistance genes (ARGs), and the important findings from each one-health sector considering this concept, thereby emphasizing the significance of the One-Health approach in understanding ARG transmission.
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Epidemiological Evidence and Health Risks Associated With Agricultural Reuse of Partially Treated and Untreated Wastewater: A Review.
A. A. Adegoke,A. A. Adegoke,Isaac Dennis Amoah,Thor A. Stenström,Matthew E. Verbyla,James R. Mihelcic +5 more
TL;DR: Appropriate mitigation lies in adhering to existing guidelines such as the World Health Organization wastewater reuse guidelines and to Sanitation Safety Plans (SSPs), and improvement in hygiene practices will also provide measures against adverse health impacts.
Journal ArticleDOI
Science-based Targets for Antibiotics in Receiving Waters from Pharmaceutical Manufacturing Operations
Joan Tell,Daniel J. Caldwell,Andreas Häner,Jutta Hellstern,Birgit Hoeger,Romain Journel,Frank Mastrocco,Jim J. Ryan,Jason Snape,Jürg Oliver Straub,Jessica Vestel +10 more
TL;DR: This paper summarizes the holistic approach taken to derive science‐based receiving water targets for antibiotics discharged from manufacturing operations and includes previously unpublished, company‐generated, environmental toxicity data.
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Exploring the Animal Waste Resistome: The Spread of Antimicrobial Resistance Genes Through the Use of Livestock Manure.
Alice Checcucci,Paolo Trevisi,Diana Luise,Monica Marianna Modesto,Sonia Blasioli,Ilaria Braschi,Paola Mattarelli +6 more
TL;DR: This review analyzed the most recent research on antibiotic and ARG environmental dissemination conveyed by livestock waste to identify methods for monitoring DNA transferability and environmental conditions promoting such diffusion.
References
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Helen W. Boucher,George H. Talbot,John S. Bradley,John S. Bradley,John E. Edwards,John E. Edwards,David N. Gilbert,Louis B. Rice,Louis B. Rice,Michael Scheld,Brad Spellberg,Brad Spellberg,John G. Bartlett +12 more
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Antibiotics in the aquatic environment - A review - Part II
TL;DR: This review brings up important questions that are still open, and addresses some significant issues which must be tackled in the future for a better understanding of the behavior of antibiotics in the environment, as well as the risks associated with their occurrence.
Journal ArticleDOI
Antibiotic resistance is ancient
Vanessa M. D'Costa,Christine E. King,Lindsay Kalan,Mariya Morar,Wilson W L Sung,Carsten Schwarz,Duane G. Froese,Grant D. Zazula,Fabrice Calmels,Régis Debruyne,G. Brian Golding,Hendrik N. Poinar,Gerard D. Wright +12 more
TL;DR: Target metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments are reported and show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.
BookDOI
Water for Food Water for Life : A Comprehensive Assessment of Water Management in Agriculture
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Journal ArticleDOI
Antibiotics and antibiotic resistance in water environments
TL;DR: Methods to reduce resistant bacterial load in wastewaters, and the amount of antimicrobial agents, in most cases originated in hospitals and farms, include optimization of disinfection procedures and management of wastewater and manure.