Giovanni B. Frisoni

TL;DR: In this paper, the authors implemented a multi-site 3T MRI morphometry protocol based on vendor provided T1 structural sequences from different vendors (3D MPRAGE on Siemens and Philips, 3D IR-SPGR on GE) implemented in 8 sites located in 4 European countries.

TL;DR: In this article, the authors evaluated diagnostic accuracy of marker vs metric in separating AD from healthy and prognostic accuracy to predict progression in mild cognitive impairment, defined as the ratio between the probability of positive (negative) test outcome in patients and their healthy controls. But, the diagnostic accuracy depends on which marker (i.e., amyloid imaging, 18F-fluorodeoxyglucose [FDG]-PET, SPECT, MRI) as well as how it is measured (metric: visual, manual, semiautomated, or automated segment

TL;DR: An international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72 to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried.

TL;DR: The present findings support the 'transition hypothesis' of brain structural and functional continuity between MCI and AD and confirmed for the first time the hypothesis that the sources of resting delta rhythms are correlated with lobar brain volume.

TL;DR: Patients with mild cognitive impairment of the vascular type (MCI-V) have a distinctive clinical picture and can be identified in a clinical setting and very early preventive measures need to be devised.