M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
Georgia Salanti,Lorraine Southam,Lorraine Southam,David Altshuler,David Altshuler,Kristin Ardlie,Inês Barroso,Inês Barroso,Michael Boehnke,Marilyn C. Cornelis,Timothy M. Frayling,Harald Grallert,Niels Grarup,Leif Groop,Torben Hansen,Torben Hansen,Andrew T. Hattersley,Frank B. Hu,Kristian Hveem,Thomas Illig,Johanna Kuusisto,Markku Laakso,Claudia Langenberg,Valeriya Lyssenko,Mark I. McCarthy,Andrew D. Morris,Andrew D. Morris,Colin N. A. Palmer,Felicity Payne,Felicity Payne,Carl G. P. Platou,Laura J. Scott,Benjamin F. Voight,Benjamin F. Voight,Nicholas J. Wareham,Eleftheria Zeggini,John P. A. Ioannidis +36 more
TL;DR: A Bayesian meta-analysis approach to data from 19 studies on 17 replicated associations with type 2 diabetes yielded point estimates for the genetic effects that were very similar to those previously reported based on fixed- or random-effects models, but uncertainty about several of the effects was substantially larger.
Journal ArticleDOI
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
Geoffrey A. Walford,Stefan Gustafsson,Denis Rybin,Alena Stančáková,Han Chen,Han Chen,Ching-Ti Liu,Jaeyoung Hong,Richard A. Jensen,Kenneth Rice,Andrew P. Morris,Andrew P. Morris,Reedik Mägi,Anke Tönjes,Inga Prokopenko,Inga Prokopenko,Marcus E. Kleber,Graciela E. Delgado,Günther Silbernagel,Anne U. Jackson,Emil V. R. Appel,Niels Grarup,Joshua P. Lewis,May E. Montasser,Claes Landenvall,Claes Landenvall,Harald Staiger,Jian'an Luan,Timothy M. Frayling,Michael N. Weedon,Weijia Xie,Sonsoles Morcillo,María Teresa Martínez-Larrad,Mary L. Biggs,Yii-Der Ida Chen,Arturo Corbatón-Anchuelo,Kristine Færch,J M Gómez-Zumaquero,Mark O. Goodarzi,Jorge R. Kizer,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Aaron Leong,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Fausto Machicao,Alisa K. Manning,Gracia María Martín-Núñez,Gemma Rojo-Martínez,Jerome I. Rotter,David S. Siscovick,David S. Siscovick,Joseph M. Zmuda,Zhongyang Zhang,Manuel Serrano-Ríos,Ulf Smith,Federico Soriguer,Torben Hansen,Torben Jørgensen,Torben Jørgensen,Allan Linnenberg,Oluf Pedersen,Mark Walker,Claudia Langenberg,Robert A. Scott,Nicholas J. Wareham,Andreas Fritsche,Hans-Ulrich Häring,Norbert Stefan,Leif Groop,Leif Groop,Jeffrey R. O'Connell,Michael Boehnke,Richard N. Bergman,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Winfried März,Winfried März,Winfried März,Peter Kovacs,Michael Stumvoll,Bruce M. Psaty,Bruce M. Psaty,Johanna Kuusisto,Markku Laakso,James B. Meigs,Josée Dupuis,Josée Dupuis,Erik Ingelsson,Erik Ingelsson,Jose C. Florez +93 more
TL;DR: A genome-wide association study of the modified Stumvoll Insulin Sensitivity Index (ISI) was performed within the Meta-Analyses of Glucose and Insulin-Related Traits Consortium, identifying two novel loci and replicated known variants associated with insulin sensitivity.
Journal ArticleDOI
Assessing Whether an Allele Can Account in Part for a Linkage Signal: The Genotype-IBD Sharing Test (GIST)
TL;DR: For samples of 500 affected sib pairs, the tests are powerful in detection of genotype-IBD sharing association, even for disease models with sib relative risk as low as lambda S=1.1, which makes the method a new tool for detecting linkage as well as association.
Journal ArticleDOI
Clinical Phenotype of Juvenile-onset Primary Open-angle Glaucoma Linked to Chromosome 1q*
A. Tim Johnson,Julia E. Richards,Michael Boehnke,Heather M. Stringham,Sarah B. Herman,Deborah J. Wong,Paul R. Lichter +6 more
TL;DR: A previously unpublished family in which juvenile-onset primary open-angle glaucoma is segregating in an autosomal dominant manner is described, with a candidate interval smaller than that in previous reports.
Journal ArticleDOI
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.
Wei Zhou,Ben Michael Brumpton,Ben Michael Brumpton,Omer Kabil,Julius Gudmundsson,Gudmar Thorleifsson,Josh Weinstock,Matthew Zawistowski,Jonas B. Nielsen,Jonas B. Nielsen,Layal Chaker,Marco Medici,Alexander Teumer,Silvia Naitza,Serena Sanna,Ulla T. Schultheiss,Anne R. Cappola,Juha Karjalainen,Mitja I. Kurki,Morgan Oneka,Peter N. Taylor,Lars G. Fritsche,Sarah E. Graham,Brooke N. Wolford,William Overton,Humaira Rasheed,Humaira Rasheed,Eirin B. Haug,Eirin B. Haug,Maiken Elvestad Gabrielsen,Anne Heidi Skogholt,Ida Surakka,George Davey Smith,George Davey Smith,Anita Pandit,Tanmoy Roychowdhury,Whitney E. Hornsby,Jon G. Jonasson,Leigha Senter,Sandya Liyanarachchi,Matthew D. Ringel,Li Xu,Lambertus A. Kiemeney,Huiling He,Romana T. Netea-Maier,Jose I. Mayordomo,Theo S. Plantinga,Jon Hrafnkelsson,Hannes Hjartarson,Erich M. Sturgis,Aarno Palotie,Mark J. Daly,Cintia Eliana Citterio,Cintia Eliana Citterio,Peter Arvan,Chad M. Brummett,Michael Boehnke,Albert de la Chapelle,Kari Stefansson,Kari Stefansson,Kristian Hveem,Kristian Hveem,Cristen J. Willer,Bjørn Olav Åsvold +63 more
TL;DR: A GWAS and two-sample Mendelian randomization using TSH index variants as instrumental variables suggests a protective effect of higher TSH levels (indicating lower thyroid function) on risk of thyroid cancer and goiter.