M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Jennifer Wessel,Audrey Y. Chu,Sara M. Willems,Shuai Wang,Hanieh Yaghootkar,Jennifer A. Brody,Marco Dauriz,Sridharan Raghavan,Leonard Lipovich,Bertha Hidalgo,Keolu Fox,Jennifer E. Huffman,Ping An,Yingchang Lu,Laura J. Rasmussen-Torvik,Niels Grarup,Margaret G. Ehm,Li Li,Abigail S. Baldridge,Alena Stančáková,Ravinder Abrol,Céline Besse,Anne Boland,Jette Bork-Jensen,Myriam Fornage,Daniel F. Freitag,Melissa E. Garcia,Xiuqing Guo,Hara Kazuo,Aaron Isaacs,Johanna Jakobsdottir,Leslie A. Lange,Jill Layton,Man Li,Jing Hua Zhao,Karina Meidtner,Alanna C. Morrison,Mike A. Nalls,Marjolein J. Peters,Maria Sabater-Lleal,Claudia Schurmann,Angela Silveira,Albert V. Smith,Lorraine Southam,Marcus H. Stoiber,Rona J. Strawbridge,Kent D. Taylor,Tibor V. Varga,Kristine H. Allin,Najaf Amin,Jennifer L. Aponte,Tin Aung,Caterina Barbieri,Nathan A. Bihlmeyer,Michael Boehnke,Cristina Bombieri,Donald W. Bowden,Sean M. Burns,Yuning Chen,Yii Deri Chen,Ching-Yu Cheng,Adolfo Correa,Jacek Czajkowski,Abbas Dehghan,Georg Ehret,Gudny Eiriksdottir,Stefan A. Escher,Aliki-Eleni Farmaki,Mattias Frånberg,Giovanni Gambaro,Franco Giulianini,William A. Goddard,Anuj Goel,Omri Gottesman,Megan L. Grove,Stefan Gustafsson,Yang Hai,Göran Hallmans,Jiyoung Heo,Per Hoffmann,Mohammad Kamran Ikram,Richard A. Jensen,Marit E. Jørgensen,Torben Jørgensen,Maria Karaleftheri,Chiea Chuen Khor,Andrea Kirkpatrick,Aldi T. Kraja,Johanna Kuusisto,Ethan M. Lange,I-Te Lee,Wen Jane Lee,Aaron Leong,Jiemin Liao,Chunyu Liu,Yongmei Liu,Cecilia M. Lindgren,Allan Linneberg,Giovanni Malerba,Vasiliki Mamakou,Eirini Marouli,Nisa M. Maruthur,Angela Matchan,Roberta McKean-Cowdin,Olga McLeod,Ginger A. Metcalf,Karen L. Mohlke,Donna M. Muzny,Ioanna Ntalla,Nicholette D. Palmer,Dorota Pasko,Andreas Peter,Nigel W. Rayner,Frida Renström,Kenneth Rice,Cinzia Sala,Bengt Sennblad,Ioannis Serafetinidis,Jennifer A. Smith,Nicole Soranzo,Elizabeth K. Speliotes,Eli A. Stahl,Kathleen Stirrups,Nikos Tentolouris,Anastasia Thanopoulou,Mina Torres,Michela Traglia,Emmanouil Tsafantakis,Sundas Javad,Lisa R. Yanek,Eleni Zengini,Diane M. Becker,Joshua C. Bis,James B. Brown,L. Adrienne Cupples,Torben Hansen,Erik Ingelsson,Andrew J. Karter,Carlos Lorenzo,Rasika A. Mathias,Jill M. Norris,Gina M. Peloso,Wayne Huey-Herng Sheu,Daniela Toniolo,Dhananjay Vaidya,Rohit Varma,Lynne E. Wagenknecht,Heiner Boeing,Erwin P. Bottinger,George Dedoussis,Panos Deloukas,Ele Ferrannini,Oscar H. Franco,Paul W. Franks,Richard A. Gibbs,Vilmundur Gudnason,Anders Hamsten,Tamara B. Harris,Andrew T. Hattersley,Caroline Hayward,Albert Hofman,Jan-Håkan Jansson,Claudia Langenberg,Lenore J. Launer,Daniel Levy,Ben A. Oostra,Christopher J. O'Donnell,Stephen O'Rahilly,Sandosh Padmanabhan,James S. Pankow,Ozren Polasek,Michael A. Province,Stephen S. Rich,Paul M. Ridker,Igor Rudan,Matthias B. Schulze,Blair H. Smith,André G. Uitterlinden,Mark Walker,Hugh Watkins,Tien Yin Wong,Eleftheria Zeggini,Markku Laakso,Ingrid B. Borecki,Daniel I. Chasman,Oluf Pedersen,Bruce M. Psaty,E. Shyong Tai,Cornelia M. van Duijn,Nicholas J. Wareham,Dawn M. Waterworth,Eric Boerwinkle,W. H. Linda Kao,Jose C. Florez,Ruth J. F. Loos,James G. Wilson,Timothy M. Frayling,David S. Siscovick,Josée Dupuis,Jerome I. Rotter,James B. Meigs,Robert A. Scott,Mark O. Goodarzi +202 more
TL;DR: In this article, the role of coding variation on intermediate traits for type 2 diabetes was explored by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls.
Journal ArticleDOI
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
John R. B. Perry,Michael N. Weedon,Claudia Langenberg,Anne U. Jackson,Valeriya Lyssenko,Thomas Sparsø,Gudmar Thorleifsson,Harald Grallert,Luigi Ferrucci,Marcello Maggio,Giuseppe Paolisso,Mark Walker,Colin N. A. Palmer,Felicity Payne,Elizabeth H. Young,Christian Herder,Narisu Narisu,Mario A. Morken,Lori L. Bonnycastle,Katharine R. Owen,Beverley M. Shields,Beatrice Knight,Amanda J. Bennett,Christopher J. Groves,Aimo Ruokonen,Marjo-Riitta Järvelin,Ewan R. Pearson,Laura Pascoe,Ele Ferrannini,Stefan R. Bornstein,Heather M. Stringham,Laura J. Scott,Johanna Kuusisto,Peter Nilsson,Malin Neptin,Anette P. Gjesing,Charlotta Pisinger,Torsten Lauritzen,Annelli Sandbæk,Mike Sampson,Ele Zeggini Magic,Cecilia M. Lindgren,Valgerdur Steinthorsdottir,Unnur Thorsteinsdottir,Torben Hansen,Peter Schwarz,Thomas Illig,Markku Laakso,Kari Stefansson,Andrew D. Morris,Leif Groop,Oluf Pedersen,Oluf Pedersen,Michael Boehnke,Inês Barroso,Nicholas J. Wareham,Andrew T. Hattersley,Mark I. McCarthy,Timothy M. Frayling +58 more
TL;DR: Evidence is added that SHBG and sex hormones are involved in the aetiology of type 2 diabetes, and a common single nucleotide polymorphism near the SHBG gene, rs1799941, that is strongly associated with SHBG levels is selected.
Journal ArticleDOI
Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1
Morris J. Bown,Gregory T. Jones,Seamus C. Harrison,Benjamin J. Wright,Suzannah Bumpstead,Annette F. Baas,Solveig Gretarsdottir,Stephen A. Badger,Declan Bradley,kevin Burnand,Anne H. Child,Rachel E. Clough,Gillian W. Cockerill,Hany Hafez,D. Julian A. Scott,Simon Futers,Anne Johnson,S Sohrabi,Alberto Smith,Matthew M Thompson,Frank M. van Bockxmeer,Matthew Waltham,Stefan E Matthiasson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Jan D. Blankensteijn,Joep A.W. Teijink,Cisca Wijmenga,Jacqueline de Graaf,Lambertus A. Kiemeney,Themistocles L. Assimes,Ruth McPherson,Lasse Folkersen,Anders Franco-Cereceda,Jutta Palmen,Andrew Smith,Nicolas Sylvius,J.B. Wild,Mette Refstrup,Sarah Edkins,Rhian Gwilliam,Sarah E. Hunt,Simon C. Potter,Jes S. Lindholt,Ruth Frikke-Schmidt,Anne Tybjærg-Hansen,Anne E. Hughes,Jonathan Golledge,Paul Norman,Andre A van Rij,Janet T. Powell,Per Eriksson,Kari Stefansson,Kari Stefansson,John R. Thompson,Steve E. Humphries,Robert D. Sayers,Panos Deloukas,Nilesh J. Samani,Heribert Schunkert,Inke R. König,Sekar Kathiresan,Muredach P. Reilly,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Diane M. Becker,Lewis C. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Eric Boerwinkle,Peter S. Braund,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Sven Cichon,Veryan Codd,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Patrick Diemert,Ron Do,Angela Doering,Sandra Eifert,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Vilmundur Gudnason,Jeffrey R. Gulcher,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,John J.P. Kastelein,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Reijo Laaksonen,Diether Lambrechts,Karin Leander,Guillaume Lettre,Man Li,Wolfgang Lieb,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Christa Meisinger,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Thomas Münzel,Kiran Musunuru,Janja Nahrstaedt,Christopher P. Nelson,Markus M. Nöthen,Oliviero Olivieri,Riyaz S. Patel,Christopher Patterson,Annette Peters,Flora Peyvandi,Liming Qu,Arshed A. Quyyumi,Daniel J. Rader,Loukianos S. Rallidis,Catherine M. Rice,Frits R. Rosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Schäfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Suthesh Sivapalaratnam,Tamara B. Smith,Jaapjan D. Snoep,Nicole Soranzo,John A. Spertus,Klaus Stark,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Stephanie Tennstedt,Gudmundur Thorgeirsson,Maciej Tomaszewski,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Philipp S. Wild,Christina Willenborg,Jaqueline C M Witteman,Shu Ye,Tanja Zeller,Andreas Ziegler,François Cambien,Alison H. Goodall,L. Adrienne Cupples,Thomas Quertermous,Winfried März,Christian Hengstenberg,Stefan Blankenberg,Willem H. Ouwehand,Alistair S. Hall,Robert Roberts,Christopher J. O'Donnell,Jeanette Erdmann,Christopher Newton-Cheh,Toby Johnson,Vesela Gateva,Martin D. Tobin,Murielle Bochud,Lachlan J. M. Coin,Samer S. Najjar,Jing Hua Zhao,Simon Heath,Susana Eyheramendy,Konstantinos A. Papadakis,Laura J. Scott,Feng Zhang,Martin Farrall,Toshiko Tanaka,Chris Wallace,John C. Chambers,Peter M. Nilsson,Pim van der Harst,Silvia Polidoro,Diederick E. Grobbee,N. Charlotte Onland-Moret,Michiel L. Bots,Louise V. Wain,Katherine S. Elliott,Alexander Teumer,Jian'an Luan,Gavin Lucas,Johanna Kuusisto,Paul Burton,David Hadley,Wendy L. McArdle,Morris J. Brown,Anna F. Dominiczak,Stephen J. Newhouse,John Webster,Eleftheria Zeggini,Jacques S. Beckmann,Noha Lim,Kijoung Song,Peter Vollenweider,Gérard Waeber,Dawn M. Waterworth,Xin Yuan,Leif Groop,Leif Groop,Marju Orho-Melander,Alessandra Allione,Alessandra Di Gregorio,Simonetta Guarrera,Salvatore Panico,Fulvio Ricceri,Valeria Romanazzi,Carlotta Sacerdote,Paolo Vineis,Inês Barroso,Robert Luben,Gabriel Crawford,Pekka Jousilahti,Markus Perola,Michael Boehnke,Lori L. Bonnycastle,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Timo T. Valle,Cristen J. Willer,Richard N. Bergman,Mario A. Morken,Angela Döring,Elin Org,Arne Pfeufer,Jaume Marrugat,Isaac Subirana,Nelson B. Freimer,Anna-Liisa Hartikainen,Mark I. McCarthy,Paul F. O'Reilly,Leena Peltonen,Anneli Pouta,Paul E. de Jong,Harold Snieder,Wiek H. van Gilst,Robert Clarke,Anuj Goel,Anders Hamsten,John F. Peden,Udo Seedorf,Ann-Christine Syvänen,Giovanni Tognoni,Edward G. Lakatta,Serena Sanna,Paul Scheet,David Schlessinger,Angelo Scuteri,Marcus Dörr,Florian Ernst,Stephan B. Felix,Georg Homuth,Roberto Lorbeer,Thorsten Reffelmann,Rainer Rettig,Uwe Völker,Pilar Galan,Ivo Gut,Serge Hercberg,G. Mark Lathrop,Diana Zelenika,Frances M K Williams,Guangju Zhai,Markku Laakso,Nita G. Forouhi,Henry Völzke,Cuno S.P.M. Uiterwaal,Yvonne T. van der Schouw,Mattijs E. Numans,Giuseppe Matullo,Gerjan Navis,Göran Berglund,Sheila Bingham,Jaspal S. Kooner,John M. C. Connell,Stefania Bandinelli,Luigi Ferrucci,Hugh Watkins,Tim D. Spector,Jaakko Tuomilehto,David P. Strachan,Maris Laan,Pierre Meneton,Manuela Uda,Marjo-Riitta Järvelin,Ruth J. F. Loos,Paul Elliott,Gonçalo R. Abecasis,Mark J. Caulfield,Patricia B. Munroe,Valgerdur Steinthorsdottir,Andrew P. Morris,Christian Dina,Christian Dina,Ryan P. Welch,Cornelia Huth,Yurii S. Aulchenko,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,Guanming Wu,Soumya Raychaudhuri,Soumya Raychaudhuri,Steve McCarroll,Steve McCarroll,Claudia Langenberg,Oliver Hofmann,Josée Dupuis,Josée Dupuis,Lu Qi,Ayellet V. Segrè,Ayellet V. Segrè,Mandy van Hoek,Pau Navarro,Kristin G. Ardlie,Beverley Balkau,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Kristina Bengtsson Boström,Bert Bravenboer,Noël P. Burtt,Guillaume Charpentier,Peter S. Chines,Marilyn C. Cornelis,David Couper,Gabe Crawford,Alex S. F. Doney,Amanda L. Elliott,Amanda L. Elliott,Michael R. Erdos,Caroline S. Fox,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Niels Grarup,Todd Green,Todd Green,Simon J. Griffin,Christopher J. Groves,Candace Guiducci,Samy Hadjadj,Neelam Hassanali,Christian Herder,Bo Isomaa,Paul Johnson,Torben Jørgensen,Wen H. L. Kao,Norman Klopp,Peter Kraft,Torsten Lauritzen,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Michel Marre,Michel Marre,Kristian Midthjell,Narisu Narisu,Katharine R. Owen,Felicity Payne,John R. B. Perry,Ann-Kristin Petersen,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Wolfgang Rathmann,N. William Rayner,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,Richa Saxena,Beverley M. Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Qi Sun,Amy J. Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,Rob M. van Dam,Timon W. van Haeften,Thijs T. W. van Herpt,Jana V. van Vliet-Ostaptchouk,G. Bragi Walters,Michael N. Weedon,Stéphane Cauchi,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Torben Hansen,Winston Hide,Graham A. Hitman,David J. Hunter,Kristian Hveem,Andrew D. Morris,Colin N. A. Palmer,Peter P. Pramstaller,Igor Rudan,Igor Rudan,Igor Rudan,Eric J.G. Sijbrands,Lincoln Stein,Andre G. Uitterlinden,Mark Walker,Richard M. Watanabe,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Mark J. Daly,Andrew T. Hattersley,Frank B. Hu,James B. Meigs,James S. Pankow,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Jose C. Florez,Jose C. Florez,Timothy M. Frayling,Robert Sladek,James F. Wilson,Philippe Froguel,Philippe Froguel,Cornelia M. van Duijn,Ross D. Blair,Andrew Hill,Andrew Hill,Andrew Hill,B. Gerry Hill,B. Gerry Hill,David R. Lewis,Les McNoe,Tony R. Merriman,Dilip K. Naik,L. Vicky Phillips,Ian Thomson,Ruth Topless,Thodur M. Vasudevan,Grace Yu +507 more
TL;DR: This study has identified a biologically plausible genetic variant associated specifically with AAA, and it is suggested that this variant has a possible functional role in LRP1 expression.
Journal ArticleDOI
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
Arushi Varshney,Laura J. Scott,Ryan P. Welch,Michael R. Erdos,Peter S. Chines,Narisu Narisu,Ricardo D’Oliveira Albanus,Peter Orchard,Brooke N. Wolford,Romy Kursawe,Swarooparani Vadlamudi,Maren E Cannon,John P. Didion,John Hensley,Anthony Kirilusha,Lori L. Bonnycastle,D. Leland Taylor,D. Leland Taylor,Richard M. Watanabe,Karen L. Mohlke,Michael Boehnke,Francis S. Collins,Stephen C. J. Parker,Michael L. Stitzel +23 more
TL;DR: The largest integrated analysis to date of high-resolution, high-throughput human islet molecular profiling data is presented to characterize the genome, epigenome, and transcriptome and find that T2D genetic variants are enriched in regions of the genome where transcription Regulatory Factor X (RFX) is predicted to bind in an islet-specific manner.
Journal ArticleDOI
Mutations in TCF8 Cause Posterior Polymorphous Corneal Dystrophy and Ectopic Expression of COL4A3 by Corneal Endothelial Cells
Charles M. Krafchak,Hemant Pawar,Sayoko E. Moroi,Alan Sugar,Paul R. Lichter,David A. Mackey,David A. Mackey,Shahzad I. Mian,Theresa M. Nairus,Victor M. Elner,Miriam T. Schteingart,Catherine A. Downs,Theresa Guckian Kijek,Jenae M. Johnson,Edward H. Trager,Frank W. Rozsa,Nawajes A. Mandal,Michael P. Epstein,Douglas Vollrath,Radha Ayyagari,Michael Boehnke,Julia E. Richards +21 more
TL;DR: This study has identifiedTCF8 as the gene responsible for approximately half of the cases of PPCD, has implicated TCF8 mutations in developmental abnormalities outside the eye, and has presented the TCf8 regulatory target, COL4A3, as a key, shared molecular component of two different diseases, PPCd and Alport syndrome.