M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Louise V. Wain,Germaine C. Verwoert,Paul F. O'Reilly,Gang Shi,Toby Johnson,Andrew D. Johnson,Murielle Bochud,Kenneth Rice,Peter Henneman,Albert V. Smith,Georg Ehret,Georg Ehret,Georg Ehret,Najaf Amin,Martin G. Larson,Martin G. Larson,Vincent Mooser,David Hadley,David Hadley,Marcus Doerr,Joshua C. Bis,Thor Aspelund,Tõnu Esko,A. Cecile J.W. Janssens,Jing Hua Zhao,Simon Heath,Maris Laan,Jingyuan Fu,Giorgio Pistis,Jian'an Luan,Pankaj Arora,Gavin Lucas,Nicola Pirastu,Irene Pichler,Anne U. Jackson,Rebecca J. Webster,Feng Zhang,John F. Peden,Helena Schmidt,Toshiko Tanaka,Harry Campbell,Wilmar Igl,Yuri Milaneschi,Jouke-Jan Hottenga,Veronique Vitart,Daniel I. Chasman,Stella Trompet,Jennifer L. Bragg-Gresham,Behrooz Z. Alizadeh,John C. Chambers,John C. Chambers,Xiuqing Guo,Terho Lehtimäki,Brigitte Kuehnel,Lorna M. Lopez,Ozren Polasek,Mladen Boban,Christopher P. Nelson,Alanna C. Morrison,Vasyl Pihur,Santhi K. Ganesh,Albert Hofman,Suman Kundu,Francesco U.S. Mattace-Raso,Fernando Rivadeneira,Eric J.G. Sijbrands,André G. Uitterlinden,Shih-Jen Hwang,Ramachandran S. Vasan,Thomas J. Wang,Sven Bergmann,Peter Vollenweider,Gérard Waeber,Jaana Laitinen,Anneli Pouta,Paavo Zitting,Wendy L. McArdle,Heyo K. Kroemer,Uwe Voelker,Henry Voelzke,Nicole L. Glazer,Kent D. Taylor,Tamara B. Harris,Helene Alavere,Toomas Haller,Aime Keis,Mari-Liis Tammesoo,Yurii S. Aulchenko,Inês Barroso,Kay-Tee Khaw,Pilar Galan,Serge Hercberg,Mark Lathrop,Susana Eyheramendy,Elin Org,Siim Sõber,Xiaowen Lu,Ilja M. Nolte,Brenda W.J.H. Penninx,Tanguy Corre,Corrado Masciullo,Cinzia Sala,Leif Groop,Benjamin F. Voight,Olle Melander,Christopher J. O'Donnell,Veikko Salomaa,Adamo Pio D'Adamo,Antonella Fabretto,Flavio Faletra,Sheila Ulivi,Fabiola M. Del Greco,Maurizio F. Facheris,Francis S. Collins,Richard N. Bergman,John Beilby,Joseph Hung,A. William Musk,Massimo Mangino,So-Youn Shin,Nicole Soranzo,Hugh Watkins,Anuj Goel,Anders Hamsten,Pierre Gider,Marisa Loitfelder,Marion Zeginigg,Dena G. Hernandez,Samer S. Najjar,Pau Navarro,Sarah H. Wild,Anna Maria Corsi,Andrew B. Singleton,Eco J. C. de Geus,Gonneke Willemsen,Alex Parker,Lynda M. Rose,Brendan M. Buckley,David J. Stott,Marco Orru,Manuela Uda,Melanie M. van der Klauw,Weihua Zhang,Xinzhong Li,James Scott,Yii-Der Ida Chen,Gregory L. Burke,Mika Kähönen,Jorma Viikari,Angela Doering,Thomas Meitinger,Gail Davies,John M. Starr,Valur Emilsson,Andrew S. Plump,Jan H.N. Lindeman,Peter A C 't Hoen,Inke R. Koenig,Janine F. Felix,Robert Clarke,Jemma C. Hopewell,Halit Ongen,Monique M.B. Breteler,Stéphanie Debette,Anita L. DeStefano,Myriam Fornage,Gary F. Mitchell,Nicholas L. Smith,Hilma Holm,Kari Stefansson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Nilesh J. Samani,Michael Preuss,Igor Rudan,Caroline Hayward,Ian J. Deary,H-Erich Wichmann,Olli T. Raitakari,Walter Palmas,Jaspal S. Kooner,Jaspal S. Kooner,Ronald P. Stolk,J. Wouter Jukema,Alan F. Wright,Dorret I. Boomsma,Stefania Bandinelli,Ulf Gyllensten,James F. Wilson,Luigi Ferrucci,Reinhold Schmidt,Martin Farrall,Tim D. Spector,Lyle J. Palmer,Jaakko Tuomilehto,Arne Pfeufer,Paolo Gasparini,David S. Siscovick,David Altshuler,Ruth J. F. Loos,Daniela Toniolo,Harold Snieder,Christian Gieger,Pierre Meneton,Nicholas J. Wareham,Ben A. Oostra,Andres Metspalu,Lenore J. Launer,Rainer Rettig,David P. Strachan,Jacques S. Beckmann,Jacqueline C. M. Witteman,Jeanette Erdmann,Ko Willems van Dijk,Eric Boerwinkle,Michael Boehnke,Paul M. Ridker,Marjo-Riitta Järvelin,Aravinda Chakravarti,Gonçalo R. Abecasis,Vilmundur Gudnason,Christopher Newton-Cheh,Daniel Levy,Patricia B. Munroe,Bruce M. Psaty,Mark J. Caulfield,Dabeeru C. Rao,Martin D. Tobin,Paul Elliott,Cornelia M. van Duijn +229 more
TL;DR: Findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP, as well as two new MAP loci associated with both of these traits.
Journal ArticleDOI
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population
Elaine T. Lim,Peter Würtz,Peter Würtz,Peter Würtz,Aki S. Havulinna,Priit Palta,Priit Palta,Taru Tukiainen,Taru Tukiainen,Karola Rehnström,Tõnu Esko,Reedik Mägi,Michael Inouye,Tuuli Lappalainen,Yingleong Chan,Yingleong Chan,Yingleong Chan,Rany M. Salem,Rany M. Salem,Monkol Lek,Monkol Lek,Jason Flannick,Jason Flannick,Xueling Sim,Alisa K. Manning,Claes Ladenvall,Claes Ladenvall,Suzannah Bumpstead,Eija Hämäläinen,Eija Hämäläinen,Kristiina Aalto,Mikael Maksimow,Marko Salmi,Stefan Blankenberg,Diego Ardissino,Svati H. Shah,Benjamin D. Horne,Ruth McPherson,G K Hovingh,Muredach P. Reilly,Hugh Watkins,Anuj Goel,Martin Farrall,Domenico Girelli,Alexander P. Reiner,Nathan O. Stitziel,Sekar Kathiresan,Stacey Gabriel,Jeffrey C. Barrett,Terho Lehtimäki,Markku Laakso,Leif Groop,Leif Groop,Jaakko Kaprio,Jaakko Kaprio,Markus Perola,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Michael Boehnke,David Altshuler,David Altshuler,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Joel N. Hirschhorn,Joel N. Hirschhorn,Andres Metspalu,Nelson B. Freimer,Tanja Zeller,Sirpa Jalkanen,Seppo Koskinen,Olli T. Raitakari,Olli T. Raitakari,Richard Durbin,Daniel G. MacArthur,Daniel G. MacArthur,Veikko Salomaa,Samuli Ripatti,Mark J. Daly,Mark J. Daly,Aarno Palotie +81 more
TL;DR: In this paper, the authors compared exome sequence data on 3,000 Finns to the same number of non-Finnish Europeans and discovered that the average Finn has more low-frequency loss-of-function variants and complete gene knockouts.
Journal ArticleDOI
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Rona J. Strawbridge,Josée Dupuis,Inga Prokopenko,Adam Barker,Emma Ahlqvist,Denis Rybin,John R. Petrie,Mary E. Travers,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Antigone S. Dimas,Antigone S. Dimas,Alexandra C. Nica,Alexandra C. Nica,Eleanor Wheeler,Han Chen,Benjamin F. Voight,Benjamin F. Voight,Jalal Taneera,Stavroula Kanoni,Stavroula Kanoni,J F Peden,Fabiola Turrini,Fabiola Turrini,Stefan Gustafsson,Carina Zabena,Peter Almgren,Barker Djp,Daniel R. Barnes,Elaine M. Dennison,Johan G. Eriksson,Per Eriksson,Elodie Eury,Elodie Eury,Lasse Folkersen,Caroline S. Fox,Caroline S. Fox,Timothy M. Frayling,Anuj Goel,Harvest F. Gu,Momoko Horikoshi,Bo Isomaa,Anne U. Jackson,Karen A. Jameson,Eero Kajantie,Julie Kerr-Conte,Julie Kerr-Conte,Teemu Kuulasmaa,Johanna Kuusisto,Loos Rjf.,Jian'an Luan,Konstantinos Makrilakis,Alisa K. Manning,María Teresa Martínez-Larrad,Narisu Narisu,M Nastase Mannila,John Öhrvik,Clive Osmond,Laura Pascoe,Felicity Payne,Avan Aihie Sayer,Bengt Sennblad,Angela Silveira,Alena Stančáková,K Stirrups,Amy J. Swift,Syvänen A-C.,Tiinamaija Tuomi,F.M. van 't Hooft,Mark Walker,Michael N. Weedon,Weijia Xie,Björn Zethelius,Halit Ongen,Anders Mälarstig,Jemma C. Hopewell,Danish Saleheen,J Chambers,Sarah Parish,John Danesh,J Kooner,Ostenson C-G.,Lars Lind,Cyrus Cooper,Manuel Serrano-Ríos,Ele Ferrannini,Tom Forsén,Robert Clarke,MariaGrazia Franzosi,Udo Seedorf,Hugh Watkins,Philippe Froguel,Paul Johnson,Panos Deloukas,Panos Deloukas,Francis S. Collins,Markku Laakso,Emmanouil T. Dermitzakis,Michael Boehnke,Mark I. McCarthy,Nicholas J. Wareham,Leif Groop,François Pattou,François Pattou,Anna L. Gloyn,George Dedoussis,Valeriya Lyssenko,James B. Meigs,Inês Barroso,Inês Barroso,Inês Barroso,Richard M. Watanabe,Erik Ingelsson,Claudia Langenberg,Anders Hamsten,Jose C. Florez,Jose C. Florez +116 more
TL;DR: The findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis.
Journal ArticleDOI
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Marcel den Hoed,Mark Eijgelsheim,Tõnu Esko,Bianca J. J. M. Brundel,David S. Peal,David M. Evans,Ilja M. Nolte,Ayellet V. Segrè,Hilma Holm,Robert E. Handsaker,Harm-Jan Westra,Toby Johnson,Aaron Isaacs,Jian Yang,Alicia Lundby,Jing Hua Zhao,Young Jin Kim,Min Jin Go,Peter Almgren,Murielle Bochud,Gabrielle Boucher,Marilyn C. Cornalis,Daniel F. Gudbjartsson,David Hadley,Pim van der Harst,Caroline Hayward,Martin den Heijer,Wilmar Igl,Anne U. Jackson,Zoltán Kutalik,Jian'an Luan,John P. Kemp,Kati Kristiansson,Claes Ladenvall,Mattias Lorentzon,May E. Montasser,Omer T. Njajou,Paul F. O'Reilly,Sandosh Padmanabhan,Beate St Pourcain,Tuomo Rankinen,Perttu Salo,Toshiko Tanaka,Nicholas J. Timpson,Veronique Vitart,Lindsay L. Waite,William Wheeler,Weihua Zhang,Harmen H.M. Draisma,Mary F. Feitosa,Kathleen F. Kerr,Penelope A. Lind,Evelin Mihailov,N. Charlotte Onland-Moret,Ci Song,Michael N. Weedon,Weijia Xie,Loic Yengo,Devin Absher,Christine M. Albert,Alvaro Alonso,Dan E. Arking,Paul I.W. de Bakker,Beverley Balkau,Cristina Barlassina,Paola Benaglio,Joshua C. Bis,Nabila Bouatia-Naji,Soren Brage,Stephen J. Chanock,Peter S. Chines,Mina K. Chung,Dawood Darbar,Christian Dina,Marcus Dörr,Paul Elliott,Stephan B. Felix,Krista Fischer,Christian Fuchsberger,Eco J. C. de Geus,Philippe Goyette,Vilmundur Gudnason,Tamara B. Harris,Anna-Liisa Hartikainen,Aki S. Havulinna,Susan R. Heckbert,Andrew A. Hicks,Albert Hofman,Suzanne Holewijn,Femke Hoogstra-Berends,Jouke-Jan Hottenga,Majken K. Jensen,Åsa Johansson,Juhani Junttila,Stefan Kääb,Bart Kanon,Shamika Ketkar,Kay-Tee Khaw,Joshua W. Knowles,Angad S. Kooner,Jan A. Kors,Meena Kumari,Lili Milani,Päivi Laiho,Edward G. Lakatta,Claudia Langenberg,Maarten Leusink,Yongmei Liu,Robert Luben,Kathryn L. Lunetta,Stacey N. Lynch,Marcello Ricardo Paulista Markus,Pedro Marques-Vidal,Irene Mateo Leach,Wendy L. McArdle,Steven A. McCarroll,Sarah E. Medland,Kathryn Miller,Grant W. Montgomery,Alanna C. Morrison,Martina Müller-Nurasyid,Pau Navarro,Mari Nelis,Jeffrey R. O'Connell,Christopher J. O'Donnell,Ken K. Ong,Anne B. Newman,Annette Peters,Ozren Polasek,Anneli Pouta,Peter P. Pramstaller,Bruce M. Psaty,Dabeeru C. Rao,Susan M. Ring,Elizabeth J. Rossin,Diana Rudan,Serena Sanna,Robert A. Scott,Jaban S. Sehmi,Stephen J. Sharp,Jordan T. Shin,Andrew B. Singleton,Albert V. Smith,Nicole Soranzo,Tim D. Spector,Chip Stewart,Heather M. Stringham,Kirill V. Tarasov,André G. Uitterlinden,Liesbeth Vandenput,Shih-Jen Hwang,John Whitfield,Cisca Wijmenga,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Jacqueline C. M. Witteman,Andrew Wong,Quenna Wong,Yalda Jamshidi,Paavo Zitting,Jolanda M. A. Boer,Dorret I. Boomsma,Ingrid B. Borecki,Cornelia M. van Duijn,Ulf Ekelund,Nita G. Forouhi,Philippe Froguel,Aroon D. Hingorani,Erik Ingelsson,Mika Kivimäki,Richard A. Kronmal,Diana Kuh,Lars Lind,Nicholas G. Martin,Ben A. Oostra,Nancy L. Pedersen,Thomas Quertermous,Jerome I. Rotter,Yvonne T. van der Schouw,W. M. Monique Verschuren,Mark Walker,Demetrius Albanes,David O. Arnar,Themistocles L. Assimes,Stefania Bandinelli,Michael Boehnke,Rudolf A. de Boer,Claude Bouchard,L Mark Caulfield W L Mark Caulfield,John C. Chambers,Gary C. Curhan,Daniele Cusi,Johan G. Eriksson,Luigi Ferrucci,Wiek H. van Gilst,Nicola Glorioso,Jacqueline de Graaf,Leif Groop,Ulf Gyllensten,Wen Chi Hsueh,Frank B. Hu,Heikki V. Huikuri,David J. Hunter,Carlos Iribarren,Bo Isomaa,Marjo-Riitta Järvelin,Antti Jula,Mika Kähönen,Lambertus A. Kiemeney,Melanie M. van der Klauw,Jaspal S. Kooner,Peter Kraft,Licia Iacoviello,Terho Lehtimäki,Marja-Liisa Lokki,Braxton D. Mitchell,Gerjan Navis,Markku S. Nieminen,Claes Ohlsson,Neil Poulter,Lu Qi,Olli T. Raitakari,Eric B. Rimm,John D. Rioux,Federica Rizzi,Igor Rudan,Veikko Salomaa,Peter S. Sever,Denis C. Shields,Alan R. Shuldiner,Juha Sinisalo,Alice Stanton,Ronald P. Stolk,David P. Strachan,Jean-Claude Tardif,Unnur Thorsteinsdottir,J. Tuomilehto,Dirk J. van Veldhuisen,Jarmo Virtamo,Jorma Viikari,Peter Vollenweider,Gérard Waeber,Elisabeth Widen,Yoon Shin Cho,Jesper V. Olsen,Peter M. Visscher,Cristen J. Willer,Lude Franke,Jeanette Erdmann,John R. Thompson,Arne Pfeufer,Nona Sotoodehnia,Christopher Newton-Cheh,Patrick T. Ellinor,Bruno H. Stricker,Andres Metspalu,Markus Perola,Jacques S. Beckmann,George Davey Smith,Kari Stefansson,Nicholas J. Wareham,Patricia B. Munroe,Ody C. M. Sibon,David J. Milan,Harold Snieder,Nilesh J. Samani,Ruth J. F. Loos +267 more
TL;DR: A 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci, providing fresh insights into the mechanisms regulating heart rate.
Journal ArticleDOI
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Georg Ehret,Georg Ehret,Teresa Ferreira,Daniel I. Chasman,Anne U. Jackson,Ellen M. Schmidt,Toby Johnson,Toby Johnson,Gudmar Thorleifsson,Jian'an Luan,Louise A. Donnelly,Stavroula Kanoni,Ann-Kristin Petersen,Vasyl Pihur,Rona J. Strawbridge,Dmitry Shungin,Dmitry Shungin,Maria Hughes,Osorio Meirelles,Marika Kaakinen,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Kati Kristiansson,Kati Kristiansson,Sonia Shah,Marcus E. Kleber,Xiuqing Guo,Leo-Pekka Lyytikäinen,Cristiano Fava,Cristiano Fava,Niclas Eriksson,Ilja M. Nolte,Patrik K. E. Magnusson,Elias Salfati,Loukianos S. Rallidis,Elizabeth Theusch,Andrew J. Smith,Lasse Folkersen,Kate Witkowska,Tune H. Pers,Roby Joehanes,Stuart K. Kim,Lazaros Lataniotis,Rick Jansen,Andrew D. Johnson,Helen R. Warren,Young Jin Kim,Wei Zhao,Ying Wu,Bamidele O. Tayo,Murielle Bochud,Devin Absher,Linda S. Adair,Najaf Amin,Dan E. Arking,Tomas Axelsson,Damiano Baldassarre,Beverley Balkau,Stefania Bandinelli,Michael R. Barnes,Inês Barroso,Inês Barroso,Stephen Bevan,Joshua C. Bis,Gyda Bjornsdottir,Michael Boehnke,Eric Boerwinkle,Lori L. Bonnycastle,Dorret I. Boomsma,Stefan R. Bornstein,Morris Brown,Michel Burnier,Claudia P. Cabrera,John C. Chambers,John C. Chambers,John C. Chambers,I. Shou Chang,Ching-Yu Cheng,Ching-Yu Cheng,Peter S. Chines,Ren-Hua Chung,Francis S. Collins,John M. C. Connell,Angela Döring,Jean Dallongeville,John Danesh,John Danesh,Ulf de Faire,Graciela E. Delgado,Anna F. Dominiczak,Alex S. F. Doney,Fotios Drenos,Fotios Drenos,Sarah Edkins,John D. Eicher,Roberto Elosua,Stefan Enroth,Jeanette Erdmann,Per Eriksson,Tõnu Esko,Tõnu Esko,Tõnu Esko,Evangelos Evangelou,Evangelos Evangelou,Alun Evans,Tove Fall,Martin Farrall,Janine F. Felix,Jean Ferrières,Luigi Ferrucci,Myriam Fornage,Terrence Forrester,Nora Franceschini,Oscar H. Franco,Anders Franco-Cereceda,Ross M. Fraser,Santhi K. Ganesh,He Gao,Karl Gertow,Francesco Gianfagna,Bruna Gigante,Franco Giulianini,Anuj Goel,Alison H. Goodall,Alison H. Goodall,Mark O. Goodarzi,Mathias Gorski,Jürgen Gräßler,Christopher J. Groves,Vilmundur Gudnason,Ulf Gyllensten,Göran Hallmans,Anna-Liisa Hartikainen,Maija Hassinen,Aki S. Havulinna,Caroline Hayward,Serge Hercberg,Karl-Heinz Herzig,Andrew A. Hicks,Aroon D. Hingorani,Joel N. Hirschhorn,Joel N. Hirschhorn,Albert Hofman,Albert Hofman,Jostein Holmen,Oddgeir L. Holmen,Jouke-Jan Hottenga,Phil Howard,Chao A. Hsiung,Steven C. Hunt,Steven C. Hunt,M. Arfan Ikram,Thomas Illig,Carlos Iribarren,Richard A. Jensen,Mika Kähönen,Hyun Min Kang,Sekar Kathiresan,Sekar Kathiresan,Brendan J. Keating,Kay-Tee Khaw,Yun Kyoung Kim,Eric Kim,Mika Kivimäki,Norman Klopp,Genovefa Kolovou,Pirjo Komulainen,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Gulum Kosova,Gulum Kosova,Ronald M. Krauss,Diana Kuh,Zoltán Kutalik,Zoltán Kutalik,Johanna Kuusisto,Kirsti Kvaløy,Timo A. Lakka,Nanette R. Lee,I. Te Lee,Wen Jane Lee,Daniel Levy,Xiaohui Li,Kae Woei Liang,Honghuang Lin,Honghuang Lin,Li Lin,Jaana Lindström,Stéphane Lobbens,Stéphane Lobbens,Satu Männistö,Gabriele Müller,Martina Müller-Nurasyid,François Mach,Hugh S. Markus,Eirini Marouli,Eirini Marouli,Mark I. McCarthy,Colin A. McKenzie,Pierre Meneton,Cristina Menni,Andres Metspalu,Vladan Mijatovic,Leena Moilanen,Leena Moilanen,May E. Montasser,Andrew D. Morris,Alanna C. Morrison,Antonella Mulas,Ramaiah Nagaraja,Narisu Narisu,Kjell Nikus,Christopher J. O'Donnell,Christopher J. O'Donnell,Paul F. O'Reilly,Ken K. Ong,Fred Paccaud,Cameron D. Palmer,Cameron D. Palmer,Afshin Parsa,Nancy L. Pedersen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Neil Poulter,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Bruce M. Psaty,Thomas Quertermous,Dabeeru C. Rao,Asif Rasheed,N. William Rayner,N. William Rayner,Frida Renström,Frida Renström,Rainer Rettig,Kenneth Rice,Robert Roberts,Lynda M. Rose,Jacques E. Rossouw,Nilesh J. Samani,Nilesh J. Samani,Serena Sanna,Jouko Saramies,Heribert Schunkert,Sylvain Sebert,Sylvain Sebert,Wayne Huey-Herng Sheu,Wayne Huey-Herng Sheu,Young Ah Shin,Xueling Sim,Xueling Sim,Johannes H. Smit,Albert V. Smith,Maria X. Sosa,Tim D. Spector,Alena Stančáková,Alice Stanton,Kathleen Stirrups,Kathleen Stirrups,Heather M. Stringham,Johan Sundström,Amy J. Swift,Ann-Christine Syvänen,E. Shyong Tai,Toshiko Tanaka,Kirill V. Tarasov,Alexander Teumer,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Martin D. Tobin,Elena Tremoli,André G. Uitterlinden,Matti Uusitupa,Ahmad Vaez,Ahmad Vaez,Dhananjay Vaidya,Cornelia M. van Duijn,Erik P A Van Iperen,Ramachandran S. Vasan,Ramachandran S. Vasan,Germaine C. Verwoert,Jarmo Virtamo,Veronique Vitart,Benjamin F. Voight,Peter Vollenweider,Aline Wagner,Louise V. Wain,Nicholas J. Wareham,Hugh Watkins,Alan B. Weder,Harm-Jan Westra,Rainford J. Wilks,Tom Wilsgaard,James F. Wilson,Tien Yin Wong,Tien Yin Wong,Tsun-Po Yang,Tsun-Po Yang,Jie Yao,Loic Yengo,Loic Yengo,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Xiaofeng Zhu,Pascal Bovet,Richard S. Cooper,Karen L. Mohlke,Danish Saleheen,Jong-Young Lee,Paul Elliott,Hinco J. Gierman,Hinco J. Gierman,Cristen J. Willer,Lude Franke,G. Kees Hovingh,Kent D. Taylor,George Dedoussis,Peter S. Sever,Andrew Wong,Lars Lind,Themistocles L. Assimes,Inger Njølstad,Peter Schwarz,Claudia Langenberg,Harold Snieder,Mark J. Caulfield,Olle Melander,Markku Laakso,Juha Saltevo,Rainer Rauramaa,Jaakko Tuomilehto,Erik Ingelsson,Erik Ingelsson,Terho Lehtimäki,Kristian Hveem,Walter Palmas,Winfried März,Winfried März,Meena Kumari,Veikko Salomaa,Yii-Der Ida Chen,Jerome I. Rotter,Philippe Froguel,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Edward G. Lakatta,Kari Kuulasmaa,Paul W. Franks,Paul W. Franks,Paul W. Franks,Anders Hamsten,H.-Erich Wichmann,H.-Erich Wichmann,Colin N. A. Palmer,Kari Stefansson,Kari Stefansson,Paul M. Ridker,Ruth J. F. Loos,Ruth J. F. Loos,Aravinda Chakravarti,Panos Deloukas,Panos Deloukas,Andrew P. Morris,Andrew P. Morris,Christopher Newton-Cheh,Christopher Newton-Cheh,Christopher Newton-Cheh,Patricia B. Munroe +375 more
TL;DR: In this article, the authors identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals, and 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues.