M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.
Valeriya Lyssenko,Cecilia Nagorny,Michael R. Erdos,Nils Wierup,Anna Jonsson,Peter Spégel,Marco Bugliani,Richa Saxena,Richa Saxena,Malin Fex,Nicolo Pulizzi,Bo Isomaa,Tiinamaija Tuomi,Peter M. Nilsson,Johanna Kuusisto,Jaakko Tuomilehto,Michael Boehnke,David Altshuler,David Altshuler,Frank Sundler,Johan G. Eriksson,Anne U. Jackson,Markku Laakso,Piero Marchetti,Richard M. Watanabe,Hindrik Mulder,Leif Groop,Leif Groop +27 more
TL;DR: In this paper, the authors showed that the risk genotype of this SNP predicts future type 2 diabetes (T2D) in two large prospective studies, and the risk was associated with impairment of early insulin response to both oral and intravenous glucose and with faster deterioration of insulin secretion over time.
Journal ArticleDOI
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
Cecilia M. Lindgren,Iris M. Heid,Joshua C. Randall,Claudia Lamina,Valgerdur Steinthorsdottir,Lu Qi,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Gudmar Thorleifsson,Cristen J. Willer,Blanca M. Herrera,Anne U. Jackson,Noha Lim,Paul Scheet,Nicole Soranzo,Nicole Soranzo,Najaf Amin,Yurii S. Aulchenko,John C. Chambers,Alexander W. Drong,Jia N.an Luan,Helen N. Lyon,Helen N. Lyon,Fernando Rivadeneira,Serena Sanna,Nicholas J. Timpson,M. Carola Zillikens,Hua Zhao Jing,Peter Almgren,Stefania Bandinelli,Amanda J. Bennett,Richard N. Bergman,Lori L. Bonnycastle,Suzannah Bumpstead,Stephen J. Chanock,Lynn Cherkas,Peter S. Chines,Lachlan J. M. Coin,Cyrus Cooper,Gabriel Crawford,Angela Doering,Anna F. Dominiczak,Alex S. F. Doney,Shah Ebrahim,Paul Elliott,Michael R. Erdos,Karol Estrada,Luigi Ferrucci,Guido Fischer,Nita G. Forouhi,Christian Gieger,Harald Grallert,Christopher J. Groves,Scott M. Grundy,Candace Guiducci,David Hadley,Anders Hamsten,Aki S. Havulinna,Albert Hofman,Rolf Holle,John W. Holloway,Thomas Illig,Bo Isomaa,Leonie C. Jacobs,Karen A. Jameson,Pekka Jousilahti,Fredrik Karpe,Johanna Kuusisto,Jaana Laitinen,G. Mark Lathrop,Debbie A Lawlor,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Mario A. Morken,Andrew P. Morris,Patricia B. Munroe,Narisu Narisu,Anna Nordström,Peter Nordström,Ben A. Oostra,Colin N. A. Palmer,Felicity Payne,John F. Peden,Inga Prokopenko,Frida Renström,Aimo Ruokonen,Veikko Salomaa,Manjinder S. Sandhu,Manjinder S. Sandhu,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Kijoung Song,Xin Yuan,Heather M. Stringham,Amy J. Swift,Tiinamaija Tuomi,Manuela Uda,Peter Vollenweider,Gérard Waeber,Chris Wallace,G. Bragi Walters,Michael N. Weedon,Jacqueline C.M. Witteman,Cuilin Zhang,Weihua Zhang,Mark J. Caulfield,Francis S. Collins,George Davey Smith,Ian N. M. Day,Paul W. Franks,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Augustine Kong,Jaspal S. Kooner,Markku Laakso,Edward G. Lakatta,Vincent Mooser,Andrew D. Morris,Leena Peltonen,Leena Peltonen,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Toshiko Tanaka,Toshiko Tanaka,Jaakko Tuomilehto,André G. Uitterlinden,Cornelia M. van Duijn,Nicholas J. Wareham,Hugh Watkins,Dawn M. Waterworth,Michael Boehnke,Panos Deloukas,Leif Groop,Leif Groop,David J. Hunter,David J. Hunter,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,David Schlessinger,H.-Erich Wichmann,Timothy M. Frayling,Gonçalo R. Abecasis,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos,Kari Stefansson,Kari Stefansson,Karen L. Mohlke,Inês Barroso,Mark I. McCarthy +155 more
TL;DR: By focusing on anthropometric measures of central obesity and fat distribution, a meta-analysis of 16 genome-wide association studies informative for adult waist circumference and waist–hip ratio identified three loci implicated in the regulation of human adiposity.
Journal ArticleDOI
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Richa Saxena,Richa Saxena,Claudia Langenberg,Toshiko Tanaka,Toshiko Tanaka,James S. Pankow,Peter Vollenweider,Valeriya Lyssenko,Nabila Bouatia-Naji,Josée Dupuis,Anne U. Jackson,W. H. Linda Kao,Man Li,Nicole L. Glazer,Alisa K. Manning,Jian Anluan,Heather M. Stringham,Inga Prokopenko,Toby Johnson,Niels Grarup,Trine Welløv Boesgaard,Cécile Lecoeur,Peter Shrader,Jeffrey R. O'Connell,Erik Ingelsson,Erik Ingelsson,David Couper,Kenneth Rice,Kijoung Song,Camilla H. Andreasen,Christian Dina,Anna Köttgen,Olivier Le Bacquer,François Pattou,Jalal Taneera,Valgerdur Steinthorsdottir,Denis Rybin,Kristin Ardlie,Mike Sampson,Lu Qi,Mandy van Hoek,Michael N. Weedon,Yurii S. Aulchenko,Benjamin F. Voight,Benjamin F. Voight,Harald Grallert,Beverley Balkau,Richard N. Bergman,Suzette J. Bielinski,Amélie Bonnefond,Lori L. Bonnycastle,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Thomas A. Buchanan,Suzannah Bumpstead,Christine Cavalcanti-Proença,Guillaume Charpentier,Yii-Der Ida Chen,Peter S. Chines,Francis S. Collins,Marilyn C. Cornelis,Gabriel Crawford,Jérôme Delplanque,Alex S. F. Doney,Josephine M. Egan,Michael R. Erdos,Mathieu Firmann,Nita G. Forouhi,Caroline S. Fox,Caroline S. Fox,Mark O. Goodarzi,J. Graessler,Aroon D. Hingorani,Bo Isomaa,Torben Jørgensen,Mika Kivimäki,Peter Kovacs,Knut Krohn,Meena Kumari,Torsten Lauritzen,Claire Levy-Marchal,Vladimir Mayor,Jarred B. McAteer,Jarred B. McAteer,David Meyre,Braxton D. Mitchell,Karen L. Mohlke,Mario A. Morken,Narisu Narisu,Colin N. Apalmer,Ruth E. Pakyz,Laura Pascoe,Felicity Payne,Daniel S. Pearson,Wolfgang Rathmann,Annelli Sandbæk,Avan Aihie Sayer,Laura J. Scott,Stephen J. Sharp,Eric J.G. Sijbrands,Andrew B. Singleton,David S. Siscovick,Nicholas L. Smith,Nicholas L. Smith,Thomas Sparsø,Amy J. Swift,Holly E. Syddall,Gudmar Thorleifsson,Anke Tönjes,Anke Tönjes,Tiinamaija Tuomi,Jaakko Tuomilehto,Valle Tt,Gerard Waeber,Andrew Walley,Dawn M. Waterworth,Eleftheria Zeggini,Jing Hua Zhao,Thomas Illig,H.-Erich Wichmann,H.-Erich Wichmann,James F. Wilson,Cornelia M. van Duijn,Frank B. Hu,Frank B. Hu,Andrew D. Morris,Timothy M. Frayling,Timothy M. Frayling,Andrew T. Hattersley,Andrew T. Hattersley,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Peter M. Nilsson,Ann-Christine Syvänen,Alan R. Shuldiner,Alan R. Shuldiner,Mark Walker,Stefan R. Bornstein,Peter Schwarz,Gordon H. Williams,David M. Nathan,Johanna Kuusisto,Markku Laakso,Cyrus Cooper,Michael Marmot,Luigi Ferrucci,Vincent Mooser,Michael Stumvoll,Ruth J. F. Loos,David Altshuler,David Altshuler,Bruce M. Psaty,Jerome I. Rotter,Eric Boerwinkle,Torben Hansen,Torben Hansen,Oluf Pedersen,Oluf Pedersen,Jose C. Florez,Jose C. Florez,Mark I. McCarthy,Mark I. McCarthy,Michael Boehnke,Inês Barroso,Robert Sladek,Philippe Froguel,Philippe Froguel,James B. Meigs,Leif Groop,Nicholas J. Wareham,Richard M. Watanabe +173 more
TL;DR: A meta-analysis of nine genome-wide association studies and a follow-up of 29 independent loci found three newly implicated loci to be associated with type 2 diabetes: GIPR, ADCY5 and VPS13C.
Journal ArticleDOI
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Colm O'Dushlaine,Lizzy Rossin,Phil Lee,Laramie E. Duncan,Laramie E. Duncan,Neelroop N. Parikshak,Stephen Newhouse,Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Shaun Purcell,Danielle Posthuma,Danielle Posthuma,John I. Nurnberger,S. Hong Lee,Stephen V. Faraone,Roy H. Perlis,Roy H. Perlis,Bryan J. Mowry,Anita Thapar,Michael E. Goddard,John S. Witte,Devin Absher,Ingrid Agartz,Huda Akil,Farooq Amin,Ole A. Andreassen,Adebayo Anjorin,Richard Anney,Verneri Anttila,Dan E. Arking,Philip Asherson,Maria Helena Pinto de Azevedo,Lena Backlund,Judith A. Badner,Anthony J. Bailey,Tobias Banaschewski,Jack D. Barchas,Michael R. Barnes,Thomas B. Barrett,Nicholas Bass,Agatino Battaglia,Michael Bauer,Mònica Bayés,Frank Bellivier,Sarah E. Bergen,Wade H. Berrettini,Catalina Betancur,Catalina Betancur,Thomas Bettecken,Joseph Biederman,Elisabeth B. Binder,Donald W. Black,Douglas Blackwood,Cinnamon S. Bloss,Cinnamon S. Bloss,Michael Boehnke,Dorret I. Boomsma,René Breuer,Richard Bruggeman,Paul Cormican,Nancy G. Buccola,Jan K. Buitelaar,William E. Bunney,Joseph D. Buxbaum,William Byerley,Enda M. Byrne,Sian Caesar,Wiepke Cahn,Rita M. Cantor,Miguel Casas,Aravinda Chakravarti,Kimberly Chambert,Khalid Choudhury,Sven Cichon,Sven Cichon,Manuel Mattheisen,Manuel Mattheisen,C. Robert Cloninger,David A. Collier,Edwin H. Cook,Hilary Coon,Bru Cormand,Aiden Corvin,William Coryell,David Craig,Ian W. Craig,Jennifer Crosbie,Michael L. Cuccaro,David Curtis,Darina Czamara,Susmita Datta,Geraldine Dawson,Richard O. Day,Eco J. C. de Geus,Franziska Degenhardt,Srdjan Djurovic,Gary Donohoe,Alysa E. Doyle,Jubao Duan,Jubao Duan,Frank Dudbridge,Eftichia Duketis,Richard P. Ebstein,Howard J. Edenberg,Josephine Elia,Sean Ennis,Bruno Etain,Ayman H. Fanous,Ayman H. Fanous,Anne Farmer,I. Nicol Ferrier,Matthew Flicldnger,Eric Fombonne,T. Foroud,Josef Frank,Barbara Franke,Christine Fraser,Robert Freedman,Nelson B. Freimer,Christine M. Freitag,Marion Friedl,Louise Frisén,Louise Gailagher,Pablo V. Gejman,Pablo V. Gejman,Lyudmila Georgieva,Elliot S. Gershon,Ina Giegling,Michael Gill,Scott D. Gordon,Katherine Gordon-Smith,Elaine K. Green,Tiffany A. Greenwood,Dorothy E. Grice,Magdalena Gross,Detelina Grozeva,Weihua Guan,Weihua Guan,Hugh Gurling,Lieuwe de Haan,Jonathan L. Haines,Hakon Hakonarson,Joachim Hallmayer,Steven P. Hamilton,Marian L. Hamshere,Thomas Hansen,Thomas Hansen,Annette M. Hartmann,Martin Hautzinger,Andrew C. Heath,Anjali K. Henders,Stefan Herms,Stefan Herms,Ian B. Hickie,Maria Hipolito,Susanne Hoefels,Florian Holsboer,Witte J.G. Hoogendijk,Jouke-Jan Hottenga,Christina M. Hultman,Vanessa Hus,Andres Ingason,Andres Ingason,Marcus Ising,Stéphane Jamain,Edward G. Jones,Edward G. Jones,Ian Jones,Lisa Jones,Jung-Ying Tzeng,Anna K. Kaehler,René S. Kahn,Radhika Kandaswamy,Matthew C. Keller,James L. Kennedy,Elaine Kenny,Lindsey Kent,Yunjung Kim,George Kirov,Sabine M. Klauck,Lambertus Klei,James A. Knowles,Martin A. Kohli,Daniel L. Koller,Bettina Konte,Ania Korszun,Lydia Krabbendam,Robert Krasucki,Jonna Kuntsi,Phoenix Kwan,Mikael Landén,Mikael Landén,Niklas Laengstroem,Mark Lathrop,Jacob Lawrence,William Lawson,Marion Leboyer,David H. Ledbetter,Todd Lencz,Klaus-Peter Lesch,Douglas F. Levinson,Cathryn M. Lewis,Jun Li,Paul Lichtenstein,Jeffrey A. Lieberman,Danyu Lin,Don H. Linszen,Chunyu Liu,Falk W. Lohoff,Sandra K. Loo,Catherine Lord,Jennifer K. Lowe,Susanne Lucae,Donald J. MacIntyre,Donald J. MacIntyre,Pamela A. F. Madden,Elena Maestrini,Patrik K. E. Magnusson,Pamela B. Mahon,Wolfgang Maier,Anil K. Malhotra,Shrikant Mane,Christa Lese Martin,Nicholas G. Martin,Keith Matthews,Morten Mattingsdal,Steven A. McCarroll,Kevin A. McGhee,James J. McGough,Patrick J. McGrath,Peter McGuffin,Melvin G. McInnis,Andrew M. McIntosh,Rebecca McKinney,Alan W. McLean,Alan W. McLean,Francis J. McMahon,William M. McMahon,Andrew McQuillin,Helena Medeiros,Sarah E. Medland,Sandra Meier,Ingrid Melle,Fan Meng,Jobst Meyer,Christel M. Middeldorp,Lefkos T. Middleton,Vihra Milanova,Ana Miranda,Anthony P. Monaco,Anthony P. Monaco,Grant W. Montgomery,Jennifer L. Moran,Daniel Moreno-De-Luca,Gunnar Morken,Derek W. Morris,Eric M. Morrow,Valentina Moskvina,Pierandrea Muglia,Thomas W. Muehleisen,Walter J. Muir,Walter J. Muir,Bertram Mueller-Myhsok,Michael T. Murtha,Richard M. Myers,Inez Myin-Germeys,Michael C. Neale,Stan F. Nelson,Caroline M. Nievergelt,Ivan Nikolov,Vishwajit L. Nimgaonkar,Willem A. Nolen,Markus M. Noethen,Evaristus A. Nwulia,Dale R. Nyholt,Robert D. Oades,Ann Olincy,Guiomar Oliveira,Line Olsen,Line Olsen,Roel A. Ophoff,Urban Ösby,Michael John Owen,Aarno Palotie,Jeremy R. Parr,Andrew D. Paterson,Carlos N. Pato,Michele T. Pato,Brenda W.J.H. Penninx,Michele L. Pergadia,Margaret A. Pericak-Vance,Benjamin S. Pickard,Benjamin S. Pickard,Jonathan Pimm,Joseph Piven,James B. Potash,Fritz Poustka,Peter Propping,Vinay Puri,Digby Quested,Emma M. Quinn,Josep Antoni Ramos-Quiroga,Henrik B. Rasmussen,Henrik B. Rasmussen,Soumya Raychaudhuri,Karola Rehnstroem,Andreas Reif,Marta Ribasés,John P. Rice,Marcella Rietschel,Kathryn Roeder,Herbert Roeyers,Aribert Rothenberger,Guy A. Rouleau,Douglas M. Ruderfer,Dan Rujescu,Alan R. Sanders,Alan R. Sanders,Stephen Sanders,Susan L. Santangelo,Joseph A. Sergeant,Russell Schachar,Martin Schalling,Alan F. Schatzberg,William A. Scheftner,Gerard D. Schellenberg,Stephen W. Scherer,Nicholas J. Schork,Thomas G. Schulze,Thomas G. Schulze,Johannes Schumacher,Markus J. Schwarz,Edward M. Scolnick,Laura J. Scott,Jianxin Shi,Paul D. Shilling,Stanley I. Shyn,Jeremy M. Silverman,Susan L. Slager,Susan L. Smalley,Johannes H. Smit,Erin N. Smith,Edmund J.S. Sonuga-Barke,David St. Cair,Matthew W. State,Michael Steffens,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,John Strauss,Jana Strohmaier,T. Scott Stroup,James S. Sutdiffe,Peter Szatmari,Peter Szatmari,Szabocls Szelinger,Srinivasa Thirumalai,Robert C. Thompson,Alexandre A. Todorov,Federica Tozzi,Jens Treutlein,Manfred Uhr,Edwin J. C. G. van den Oord,Gerard van Grootheest,Jim van Os,Astrid M. Vicente,Veronica J. Vieland,John B. Vincent,Peter M. Visscher,Christopher A. Walsh,Christopher A. Walsh,Thomas H. Wassink,Stanley J. Watson,Myrna M. Weissman,Thomas Werge,Thomas F. Wienker,Ellen M. Wijsman,Gonneke Willemsen,Nigel Williams,A. Jeremy Willsey,Stephanie H. Witt,Wei Xu,Allan H. Young,Timothy W. Yu,Stanley Zammit,Peter P. Zandi,Peng Zhang,Frans G. Zitman,Sebastian Zoellner,Bernie Devlin,John R. Kelsoe,Pamela Sklar,Mark J. Daly,Michael Conlon O'Donovan,Nicholas John Craddock,Kenneth S. Kendler,Lauren A. Weiss,Naomi R. Wray,Zhaoming Zhao,Daniel H. Geschwind,Patrick F. Sullivan,Jordan W. Smoller,Peter Holmans,Gerome Breen +404 more
TL;DR: It is indicated that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders.
Journal ArticleDOI
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Nadeem Sarwar,Adam S. Butterworth,Daniel F. Freitag,John Gregson,Peter Willeit,Donal Gorman,Pei Gao,Danish Saleheen,Augusto Rendon,Christopher P. Nelson,Peter S. Braund,Alistair S. Hall,Daniel I. Chasman,Anne Tybjærg-Hansen,John C. Chambers,Emelia J. Benjamin,Paul W. Franks,Robert Clarke,Arthur A. M. Wilde,Mieke D. Trip,Maristella Steri,Jacqueline C. M. Witteman,Lu Qi,C. Ellen van der Schoot,Ulf de Faire,Jeanette Erdmann,Heather M. Stringham,Wolfgang Koenig,Daniel J. Rader,David Melzer,David Reich,Bruce M. Psaty,Marcus E. Kleber,Demosthenes B. Panagiotakos,Johann Willeit,Patrik Wennberg,Mark Woodward,Svetlana Adamovic,Eric B. Rimm,Tom W. Meade,Richard F. Gillum,Jonathan A. Shaffer,Albert Hofman,Altan Onat,Johan Sundström,S. Wassertheil-Smoller,Dan Mellström,John Gallacher,Mary Cushman,Russell P. Tracy,Jussi Kauhanen,Magnus Karlsson,Jukka T. Salonen,Lars Wilhelmsen,Philippe Amouyel,Bernard Cantin,Lyle G. Best,Yoav Ben-Shlomo,JoAnn E. Manson,George Davey-Smith,Paul I.W. de Bakker,Christopher J. O'Donnell,James F. Wilson,Anthony G. Wilson,Themistocles L. Assimes,John-Olov Jansson,Claes Ohlsson,Åsa Tivesten,Östen Ljunggren,Muredach P. Reilly,Anders Hamsten,Erik Ingelsson,François Cambien,Joseph Hung,G. Neil Thomas,Michael Boehnke,Heribert Schunkert,Folkert W. Asselbergs,John J.P. Kastelein,Vilmundur Gudnason,Veikko Salomaa,Tamara B. Harris,Jaspal S. Kooner,Kristine H. Allin,Kristine H. Allin,Børge G. Nordestgaard,Jemma C. Hopewell,Alison H. Goodall,Paul M. Ridker,Hilma Holm,Hugh Watkins,Willem H. Ouwehand,Nilesh J. Samani,Stephen Kaptoge,Emanuele Di Angelantonio,Olivier Harari,John Danesh +96 more
TL;DR: In this article, a functional genetic variant known to affect IL6R signalling was studied to assess whether this pathway is causally relevant to coronary heart disease, and Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking.