Michael Boehnke

TL;DR: The loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

TL;DR: The authors investigated associations of loci identified by the Meta-Analyses of Glucose and Insulin related traits Consortium (MAGIC) with circulating proinsulin, measures of insulin secretion and sensitivity from oral glucose tolerance tests (OGTTs), euglycemic clamps, insulin suppression tests, or frequently sampled intravenous glucose tolerance test in nondiabetic humans (n = 29,084).

TL;DR: The results provide suggestive evidence for linkage on 9p and identify regions requiring further study with much larger samples, to identify chromosomal regions likely to contain susceptibility alleles for early-onset obsessive-compulsive disorder.

TL;DR: The proposed meta-analysis methods for commonly used gene- or region-based rare variants tests, such as burden tests and variance component tests, are applicable to meta- analysis of multiple ancestry groups and are essentially as powerful as joint analysis by directly pooling individual level genotype data.

TL;DR: In this article, the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance was investigated.