M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.
Goo Jun,Goo Jun,Alisa K. Manning,Marcio Almeida,Matthew Zawistowski,Andrew R. Wood,Tanya M. Teslovich,Tanya M. Teslovich,Christian Fuchsberger,Christian Fuchsberger,Shuang Feng,Pablo Cingolani,Kyle J. Gaulton,Thomas D. Dyer,Thomas W. Blackwell,Han Chen,Han Chen,Peter S. Chines,Sungkyoung Choi,Claire Churchhouse,Pierre Fontanillas,Ryan King,Sungyoung Lee,Stephen E. Lincoln,Vasily Trubetskoy,Mark A. DePristo,Tasha E. Fingerlin,Robert L. Grossman,Jason Grundstad,A. C. Heath,Jayoun Kim,Young-Jin Kim,Jason M. Laramie,Jae-Hoon Lee,Heng Li,Xuanyao Liu,Oren E. Livne,Adam E. Locke,Julian Maller,Alexander Mazur,Andrew P. Morris,Andrew P. Morris,Toni I. Pollin,Derek Ragona,David Reich,Manuel A. Rivas,Laura J. Scott,Xueling Sim,Xueling Sim,Rick Tearle,Yik Ying Teo,Yik Ying Teo,Amy L. Williams,Sebastian Zöllner,Joanne E. Curran,Juan M. Peralta,Beena Akolkar,Graeme I. Bell,Noël P. Burtt,Nancy J. Cox,Nancy J. Cox,Jose C. Florez,Jose C. Florez,Craig L. Hanis,Catherine McKeon,Karen L. Mohlke,Mark Seielstad,Mark Seielstad,James G. Wilson,Gil Atzmon,Gil Atzmon,Jennifer E. Below,Josée Dupuis,Dan L. Nicolae,Donna M. Lehman,Taesung Park,Sungho Won,Robert Sladek,David Altshuler,Mark I. McCarthy,Ravindranath Duggirala,Michael Boehnke,Timothy M. Frayling,Gonçalo R. Abecasis,John Blangero +84 more
TL;DR: The results from deep whole-genome analysis of large Mexican-American pedigrees are described, suggesting that large-effect rare variants account for only a modest fraction of the genetic risk of these traits in this sample of families.
Journal ArticleDOI
LASER server: ancestry tracing with genotypes or sequence reads
Daniel Taliun,Sonia Chothani,Sebastian Schönherr,Lukas Forer,Michael Boehnke,Gonçalo R. Abecasis,Chaolong Wang +6 more
TL;DR: The LASER server is described to facilitate application of the method to a wide range of genetic studies and provides genetic ancestry estimation for different geographic regions and user‐friendly interactive visualization of the results.
Journal ArticleDOI
A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Yun Ju Sung,Lisa de las Fuentes,Thomas W. Winkler,Daniel I. Chasman,Amy R. Bentley,Aldi T. Kraja,Ioanna Ntalla,Helen R. Warren,Xiuqing Guo,Karen Schwander,Alisa K. Manning,Alisa K. Manning,Michael R. Brown,Hugues Aschard,Hugues Aschard,Mary F. Feitosa,Nora Franceschini,Yingchang Lu,Ching-Yu Cheng,Xueling Sim,Dina Vojinovic,Jonathan Marten,Solomon K. Musani,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Melissa A. Richard,Stella Aslibekyan,Traci M. Bartz,Rajkumar Dorajoo,Changwei Li,Yongmei Liu,Tuomo Rankinen,Albert V. Smith,Salman M. Tajuddin,Bamidele O. Tayo,Wei Zhao,Yanhua Zhou,Nana Matoba,Tamar Sofer,Tamar Sofer,Maris Alver,Marzyeh Amini,Mathilde Boissel,Jin-Fang Chai,Xu Chen,Jasmin Divers,Ilaria Gandin,Chuan Gao,Franco Giulianini,Anuj Goel,Sarah E. Harris,Fernando Pires Hartwig,Fernando Pires Hartwig,Meian He,Andrea R. V. R. Horimoto,Fang-Chi Hsu,Anne U. Jackson,Candace M Kammerer,Anuradhani Kasturiratne,Pirjo Komulainen,B. Kuhnel,Karin Leander,Wen-Jane Lee,Keng-Hung Lin,Jian'an Luan,Leo-Pekka Lyytikäinen,Leo-Pekka Lyytikäinen,Colin A McKenzie,Christopher P. Nelson,Christopher P. Nelson,Raymond Noordam,Robert A. Scott,Wayne Huey-Herng Sheu,Alena Stančáková,Fumihiko Takeuchi,Peter J. van der Most,Tibor V. Varga,RJ Waken,Heming Wang,Heming Wang,Yajuan Wang,Erin B. Ware,Stefan Weiss,Wanqing Wen,Lisa R. Yanek,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Saima Afaq,Tamuno Alfred,Najaf Amin,Dan E. Arking,Tin Aung,R. Graham Barr,Lawrence F. Bielak,Eric Boerwinkle,Eric Boerwinkle,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Jennifer A. Brody,Ulrich Broeckel,Brian E. Cade,Archie Campbell,Mickaël Canouil,Aravinda Chakravarti,Massimiliano Cocca,Francis S. Collins,John M. C. Connell,Renée de Mutsert,H. Janaka de Silva,Marcus Dörr,Qing Duan,Charles B. Eaton,Georg Ehret,Georg Ehret,Evangelos Evangelou,Evangelos Evangelou,Jessica D. Faul,Nita G. Forouhi,Oscar H. Franco,Yechiel Friedlander,He Gao,Bruna Gigante,C. Charles Gu,Preeti Gupta,Saskia P. Hagenaars,Tamara B. Harris,Jiang He,Sami Heikkinen,Chew-Kiat Heng,Chew-Kiat Heng,Albert Hofman,Barbara V. Howard,Barbara V. Howard,Steven C. Hunt,Steven C. Hunt,Marguerite R. Irvin,Yucheng Jia,Tomohiro Katsuya,Joel D. Kaufman,Nicola D. Kerrison,Chiea Chuen Khor,Chiea Chuen Khor,Woon-Puay Koh,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Charles Kooperberg,Jose E Krieger,Michiaki Kubo,Zoltán Kutalik,Zoltán Kutalik,Johanna Kuusisto,Timo A. Lakka,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Joseph H. Lee,Benjamin Lehne,Daniel Levy,Cora E. Lewis,Yize Li,Sing Hui Lim,Ching-Ti Liu,Jianjun Liu,Jianjun Liu,Jingmin Liu,Y Liu,Marie Loh,Marie Loh,Kurt Lohman,Tin Louie,Reedik Mägi,Koichi Matsuda,Thomas Meitinger,Andres Metspalu,Lili Milani,Yukihide Momozawa,Thomas H. Mosley,Mike A. Nalls,Ubaydah Nasri,Jeffrey R. O'Connell,Adesola Ogunniyi,Walter Palmas,Nicholette D. Palmer,James S. Pankow,Nancy L. Pedersen,Annette Peters,Patricia A. Peyser,Ozren Polasek,David J. Porteous,Olli T. Raitakari,Olli T. Raitakari,Frida Renström,Frida Renström,Treva Rice,Paul M. Ridker,Antonietta Robino,Jennifer G. Robinson,Lynda M. Rose,Igor Rudan,Charumathi Sabanayagam,Babatunde L. Salako,Kevin Sandow,Carsten Oliver Schmidt,Pamela J. Schreiner,William R. Scott,William R. Scott,Peter S. Sever,Mario Sims,Colleen M. Sitlani,Blair H. Smith,Jennifer A. Smith,Harold Snieder,John M. Starr,Konstantin Strauch,Hua Tang,Kent D. Taylor,Yik Ying Teo,Yih Chung Tham,André G. Uitterlinden,M. Waldenberger,Lihua Wang,Ya Xing Wang,Wen Bin Wei,Gregory P. Wilson,Mary K. Wojczynski,Yong-Bing Xiang,Jie Yao,Jian-Min Yuan,Alan B. Zonderman,Diane M. Becker,Michael Boehnke,Donald W. Bowden,John C. Chambers,John C. Chambers,Yii-Der Ida Chen,David R. Weir,Ulf de Faire,Ian J. Deary,Tõnu Esko,Tõnu Esko,Martin Farrall,Terrence Forrester,Barry I. Freedman,Philippe Froguel,Philippe Froguel,Paolo Gasparini,Paolo Gasparini,Christian Gieger,Bernardo L. Horta,Yi-Jen Hung,Jost B. Jonas,Jost B. Jonas,Norihiro Kato,Jaspal S. Kooner,Jaspal S. Kooner,Markku Laakso,Terho Lehtimäki,Kae-Woei Liang,Kae-Woei Liang,Patrik K. E. Magnusson,Albertine J. Oldehinkel,Alexandre C. Pereira,Alexandre C. Pereira,Thomas T. Perls,Rainer Rauramaa,Susan Redline,Rainer Rettig,Nilesh J. Samani,Nilesh J. Samani,James Scott,Xiao-Ou Shu,Pim van der Harst,Lynne E. Wagenknecht,Nicholas J. Wareham,Hugh Watkins,Ananda R. Wickremasinghe,Tangchun Wu,Yoichiro Kamatani,Cathy C. Laurie,Claude Bouchard,Richard S. Cooper,Michele K. Evans,Vilmundur Gudnason,James E. Hixson,Sharon L.R. Kardia,Stephen B. Kritchevsky,Bruce M. Psaty,Bruce M. Psaty,Rob M. van Dam,Donna K. Arnett,Dennis O. Mook-Kanamori,Myriam Fornage,Ervin R. Fox,Caroline Hayward,Cornelia M. van Duijn,E. Shyong Tai,Tien Yin Wong,Ruth J. F. Loos,Alexander P. Reiner,Charles N. Rotimi,Laura J. Bierut,Xiaofeng Zhu,L. Adrienne Cupples,Michael A. Province,Jerome I. Rotter,Paul W. Franks,Paul W. Franks,Paul W. Franks,Kenneth Rice,Paul Elliott,Mark J. Caulfield,W. James Gauderman,Patricia B. Munroe,Dabeeru C. Rao,Alanna C. Morrison +317 more
TL;DR: A genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stages 2 identified 136 loci significantly associated with MAP and/or PP and identified nine new signals near known loci.
Journal ArticleDOI
Simulation of Finnish Population History, Guided by Empirical Genetic Data, to Assess Power of Rare-Variant Tests in Finland
Sophie R. Wang,Sophie R. Wang,Sophie R. Wang,Vineeta Agarwala,Vineeta Agarwala,Vineeta Agarwala,Jason Flannick,Jason Flannick,Charleston W. K. Chiang,David Altshuler,Alisa Manning,Christopher Hartl,Pierre Fontanillas,Todd Green,Eric Banks,Mark A. DePristo,Ryan Poplin,Khalid Shakir,Timothy Fennell,Jacquelyn Murphy,Noël P. Burtt,Stacey Gabriel,Christian Fuchsberger,Hyun Min Kang,Xueling Sim,Clement Ma,Adam E. Locke,Thomas W. Blackwell,Anne U. Jackson,Tanya M. Teslovich,Heather M. Stringham,Peter S. Chines,Phoenix Kwan,Jeroen R. Huyghe,Adrian Tan,Goo Jun,Michael L. Stitzel,Richard N. Bergman,Lori L. Bonnycastle,Jaakko Tuomilehto,Francis S. Collins,Laura J. Scott,Karen L. Mohlke,Gonçalo R. Abecasis,Michael Boehnke,Tim M. Strom,Christian Gieger,Martina Müller-Nurasyid,Harald Grallert,Jennifer Kriebel,Janina S. Ried,Martin Hrabé de Angelis,Cornelia Huth,Christa Meisinger,Annette Peters,Wolfgang Rathmann,Konstantin Strauch,Thomas Meitinger,Jasmina Kravic,Claes Ladenvall,Tiinamaija Toumi,Bo Isomaa,Leif Groop,Kyle J. Gaulton,Loukas Moutsianas,Manny Rivas,Richard D. Pearson,Anubha Mahajan,Inga Prokopenko,Ashok Kumar,John R. B. Perry,Jeff Chen,Bryan Howie,Martijn van de Bunt,Kerrin S. Small,Cecilia M. Lindgren,Gerton Lunter,Neil Robertson,Will Rayner,Andrew D. Morris,David Buck,Andrew T. Hattersley,Tim D. Spector,Gil McVean,Timothy M. Frayling,Peter Donnelly,Mark I. McCarthy,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn +89 more
TL;DR: It is demonstrated that power of rare-variant association tests is higher in the Finnish population, especially when variants' phenotypic effects are tightly coupled with fitness effects and therefore reflect a greater contribution of rarer variants.
Journal ArticleDOI
Gene level meta-analysis of quantitative traits by functional linear models
TL;DR: Functional linear models are developed for meta-analyses that connect genetic data to quantitative traits, adjusting for covariates, and related test statistics can be useful in whole-genome and whole-exome association studies.