Chung Yuan Christian University

About: Chung Yuan Christian University is a education organization based out in Taoyuan City, Taiwan. It is known for research contribution in the topics: Membrane & Fuzzy logic. The organization has 9819 authors who have published 11623 publications receiving 213139 citations. The organization is also known as: Tiong-gôan-tāi-ha̍k & CYCU.

Novel poly(pyridine imide) with pendent naphthalene groups: Synthesis and thermal, optical, electrochemical, electrochromic, and protonation characterization

Abstract: A new diamine containing a pyridine heterocyclic group and a naphthalene substituent, 4-(2-naphthyl)-2,6-bis(4-aminophenyl) pyridine (NBAPP), was synthesized with the Chichibabin reaction and used in the preparation of poly(pyridine imide) by direct polycondensation with 4,4′-hexafluoroisopropylidenediphathalic anhydride in N-methyl-2-pyrrolidinone (NMP). The poly(pyridine imide) derived from diamine NBAPP with naphthalene substituents was highly organosoluble: it was soluble in tetrahydrofuran, NMP, N,N-dimethylacetamide (DMAc), N,N-dimethylformamide, and γ-butyrolactone at room temperature and in pyridine, dimethyl sulfoxide, and cyclohexanone upon heating at 70 °C. The poly(pyridine imide) was converted into lightly colored, optically transparent, flexible, and tough polyimide films via casting onto glass from a DMAc solution. This polymer exhibited good thermal stability (temperature of 10% weight loss = 527 °C) in air and high dielectric constants (as high as 4.20 at 1 kHz). The polyimide films had a tensile strength of 102 MPa and a tensile modulus of 1.8 GPa. As for the optical properties, the polymer exhibited UV–vis absorption bands in the region of 223–450 nm and possessed strong green-yellow fluorescence (500 nm) after being protonated with acid. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 2367–2374, 2007

Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy

Abstract: The treatment of intratumoral dentritic cells (DCs) commonly fails because it cannot evoke immunity in a poor tumor microenvironment (TME). Modulated electro-hyperthermia (mEHT, trade-name: oncothermia) represents a significant technological advancement in the hyperthermia field, allowing the autofocusing of electromagnetic power on a cell membrane to generate massive apoptosis. This approach turns local immunogenic cancer cell death (apoptosis) into a systemic anti-tumor immune response and may be implemented by treatment with intratumoral DCs. The CT26 murine colorectal cancer model was used in this investigation. The inhibition of growth of the tumor and the systemic anti-tumor immune response were measured. The tumor was heated to a core temperature of 42 °C for 30 min. The matured synergetic DCs were intratumorally injected 24 h following mEHT was applied. mEHT induced significant apoptosis and enhanced the release of heat shock protein70 (Hsp70) in CT26 tumors. Treatment with mEHT-DCs significantly inhibited CT26 tumor growth, relative to DCs alone or mEHT alone. The secondary tumor protection effect upon rechallenging was observed in mice that were treated with mEHT-DCs. Immunohistochemical staining of CD45 and F4/80 revealed that mEHT-DC treatment increased the number of leukocytes and macrophages. Most interestingly, mEHT also induced infiltrations of eosinophil, which has recently been reported to be an orchestrator of a specific T cell response. Cytotoxic T cell assay and ELISpot assay revealed a tumor-specific T cell activity. This study demonstrated that mEHT induces tumor cell apoptosis and enhances the release of Hsp70 from heated tumor cells, unlike conventional hyperthermia. mEHT can create a favorable tumor microenvironment for an immunological chain reaction that improves the success rate of intratumoral DC immunotherapy.

A rolling locomotion method for untethered magnetic microrobots

Abstract: It is a challenge to achieve free and efficient motion of microrobots on arbitrary surfaces. We report a rolling locomotion method for a magnetic microrobot with a rectangular body ( 300 × 200 × 50 μ m 3 ) ; this method is based on an external rotating magnetic field. The magnetic force, accompanied by normal and friction forces, enables the successive rotations of the microrobot. A magnetic field with a rotational speed of 2 rps rolls the microrobot, giving it a translation speed of 1.4 mm/s. With this locomotion ability, microrobots can move along a line or curve and can climb slopes or stairs.

An improved single-stage Flyback PFC converter for high-luminance lighting LED lamps

Abstract: This paper presents a high-performance LED lamp driver with an improved single-stage Flyback configuration. A constant current control method is used to regulate the lamp current and brightness. A laboratory prototype has been built and tested. With the prototype, high efficiency, high power factor, and constant lamp current can be achieved under different pieces of LED series connection. Copyright © 2007 John Wiley & Sons, Ltd.