Institution
Northampton Community College
Education•Bethlehem, Pennsylvania, United States•
About: Northampton Community College is a education organization based out in Bethlehem, Pennsylvania, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 3410 authors who have published 4582 publications receiving 130398 citations. The organization is also known as: Northampton County Area Community College.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This paper developed a multiple state model to project the number of people with disabilities in the United Kingdom over the next 35 years, thereby identifying implications for demand for long-term care for the elderly in the future.
Abstract: This paper develops a multiple state model to project the number of people with disabilities in the United Kingdom over the next 35 years, thereby identifying implications for demand for long-term care for the elderly in the future.The model requires three types of data: prevalence rate data, transition rate data and trends data. Recent trends in healthy life expectancy data are used to frame the assumptions made regarding changes in the disability rates of the U.K. population in the future.Although there will be a large increase in the number of elderly people in the U.K. over the next 35 years, the projections suggest that the implications for the number of elderly people requiring long-term care could be ameliorated by a reduction in the proportion of older people who are severely disabled.
90 citations
••
TL;DR: Analysis of the CD8+ T-cell responses of nine highly active antiretroviral therapy (HAART)-naïve B*2705-positive subjects suggests a previously unrecognized role played by the subdominant Pol-specific KY9 response in HLA-B* 2705-mediated control of HIV and that the recognition of HIV-infected cells by CD8- T cells early in the viral life cycle may be important for viral containment in HIV- infected individuals
Abstract: The association between HLA-B*2705 and the immune control of human immunodeficiency virus type 1 (HIV-1) has previously been linked to the targeting of the HLA-B*2705-restricted Gag epitope KRWIILGLNK (KK10) by CD8+ T cells. In order to better define the mechanisms of the HLA-B*2705 immune control of HIV, we first characterized the CD8+ T-cell responses of nine highly active antiretroviral therapy (HAART)-naive B*2705-positive subjects. Unexpectedly, we observed a strong response to an HLA-B*2705-restricted Pol epitope, KRKGGIGGY (KY9), in 8/9 subjects. The magnitude of the KY9 response was only marginally lower than that of the KK10-specific response (median, 695 versus 867 spot-forming cells [SFC]/million peripheral blood mononuclear cells [PBMCs]; not significant [NS]), and viral escape mutants were observed in both KY9 and KK10, resulting from selection pressure driven by the respective CD8+ T-cell response. By comparing inhibitions of viral replication by CD8+ T cells specific for the Gag KK10, Pol KY9, and Vpr VL9 HLA-B*2705-restricted epitopes, we observed a consistent hierarchy of antiviral efficacy (Gag KK10 > Pol KY9 > Vpr VL9). This hierarchy was associated with early recognition of HIV-1-infected cells, within 6 h of infection, by KK10- and KY9-specific CD8+ T cells but not until 18 h postinfection by VL9-specific CD8+ T cells. There was no association between antiviral efficacy and proliferative capacity, cytotoxicity, polyfunctionality, or T-cell receptor (TCR) avidity. These data are consistent with previous studies indicating an important role for the B*2705-Gag KK10 response in the control of HIV but also suggest a previously unrecognized role played by the subdominant Pol-specific KY9 response in HLA-B*2705-mediated control of HIV and that the recognition of HIV-infected cells by CD8+ T cells early in the viral life cycle may be important for viral containment in HIV-infected individuals.
90 citations
••
TL;DR: In this article, the evaporation of water droplets, impinging with low Weber number and gently depositing on heated surfaces of stainless steel is studied numerically using a combination of fluid flow and heat transfer models.
90 citations
••
TL;DR: This consensus aims to provide a better understanding of females with ADHD in order to improve recognition and referral and to adopt a lifespan model of care for girls and women with ADHD.
Abstract: There is evidence to suggest that the broad discrepancy in the ratio of males to females with diagnosed ADHD is due, at least in part, to lack of recognition and/or referral bias in females. Studies suggest that females with ADHD present with differences in their profile of symptoms, comorbidity and associated functioning compared with males. This consensus aims to provide a better understanding of females with ADHD in order to improve recognition and referral. Comprehensive assessment and appropriate treatment is hoped to enhance longer-term clinical outcomes and patient wellbeing for females with ADHD. The United Kingdom ADHD Partnership hosted a meeting of experts to discuss symptom presentation, triggers for referral, assessment, treatment and multi-agency liaison for females with ADHD across the lifespan. A consensus was reached offering practical guidance to support medical and mental health practitioners working with females with ADHD. The potential challenges of working with this patient group were identified, as well as specific barriers that may hinder recognition. These included symptomatic differences, gender biases, comorbidities and the compensatory strategies that may mask or overshadow underlying symptoms of ADHD. Furthermore, we determined the broader needs of these patients and considered how multi-agency liaison may provide the support to meet them. This practical approach based upon expert consensus will inform effective identification, treatment and support of girls and women with ADHD. It is important to move away from the prevalent perspective that ADHD is a behavioural disorder and attend to the more subtle and/or internalised presentation that is common in females. It is essential to adopt a lifespan model of care to support the complex transitions experienced by females that occur in parallel to change in clinical presentation and social circumstances. Treatment with pharmacological and psychological interventions is expected to have a positive impact leading to increased productivity, decreased resource utilization and most importantly, improved long-term outcomes for girls and women.
90 citations
••
TL;DR: Cognitive modelling work in the area of cognitive modelling is reviewed, with particular attention paid to user models (that is, the model held by a system of a user).
Abstract: Selected current and recent work in the area of cognitive modelling is reviewed. Particular attention is paid to user models (that is, the model held by a system of a user). The relevance of this work to information retrieval is assessed and some attempts to include user models in IR systems are discussed. Implications are drawn for future work in IR.
89 citations
Authors
Showing all 3411 results
Name | H-index | Papers | Citations |
---|---|---|---|
Simon Baron-Cohen | 172 | 773 | 118071 |
Pete Smith | 156 | 2464 | 138819 |
Martin N. Rossor | 128 | 670 | 95743 |
Mark D. Griffiths | 124 | 1238 | 61335 |
Richard G. Brown | 83 | 217 | 26205 |
Brendon Stubbs | 81 | 754 | 28180 |
Stuart N. Lane | 76 | 337 | 15788 |
Paul W. Burgess | 69 | 156 | 21038 |
Thomas Dietz | 68 | 203 | 37313 |
Huseyin Sehitoglu | 67 | 324 | 14378 |
Susan Golombok | 67 | 215 | 12856 |
David S.G. Thomas | 63 | 228 | 14796 |
Stephen Morris | 63 | 443 | 16484 |
Stephen Robertson | 61 | 197 | 23363 |
Michael J. Morgan | 60 | 266 | 12211 |