Rutgers University

About: Rutgers University is a education organization based out in New Brunswick, New Jersey, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 68736 authors who have published 159418 publications receiving 6713860 citations. The organization is also known as: Rutgers, The State University of New Jersey & Rutgers.

Biological Insights from Structures of Two-Component Proteins

Abstract: Two-component signal transduction based on phosphotransfer from a histidine protein kinase to a response regulator protein is a prevalent strategy for coupling environmental stimuli to adaptive responses in bacteria. In both histidine kinases and response regulators, modular domains with conserved structures and biochemical activities adopt different conformational states in the presence of stimuli or upon phosphorylation, enabling a diverse array of regulatory mechanisms based on inhibitory and/or activating protein-protein interactions imparted by different domain arrangements. This review summarizes some of the recent structural work that has provided insight into the functioning of bacterial histidine kinases and response regulators. Particular emphasis is placed on identifying features that are expected to be conserved among different two-component proteins from those that are expected to differ, with the goal of defining the extent to which knowledge of previously characterized two-component proteins can be applied to newly discovered systems.

Meta-analysis of the effects of early education interventions on cognitive and social development

Abstract: Background/ContextThere is much current interest in the impact of early childhood education programs on preschoolers and, in particular, on the magnitude of cognitive and affective gains.Purpose/Ob...

DSC: scheduling parallel tasks on an unbounded number of processors

Abstract: We present a low-complexity heuristic, named the dominant sequence clustering algorithm (DSC), for scheduling parallel tasks on an unbounded number of completely connected processors. The performance of DSC is on average, comparable to, or even better than, other higher-complexity algorithms. We assume no task duplication and nonzero communication overhead between processors. Finding the optimum solution for arbitrary directed acyclic task graphs (DAG's) is NP-complete. DSC finds optimal schedules for special classes of DAG's, such as fork, join, coarse-grain trees, and some fine-grain trees. It guarantees a performance within a factor of 2 of the optimum for general coarse-grain DAG's. We compare DSC with three higher-complexity general scheduling algorithms: the ETF by J.J. Hwang, Y.C. Chow, F.D. Anger, and C.Y. Lee (1989); V. Sarkar's (1989) clustering algorithm; and the MD by M.Y. Wu and D. Gajski (1990). We also give a sample of important practical applications where DSC has been found useful. >

Monotone control systems

Abstract: Monotone systems constitute one of the most important classes of dynamical systems used in mathematical biology modeling. The objective of this paper is to extend the notion of monotonicity to systems with inputs and outputs, a necessary first step in trying to understand interconnections, especially including feedback loops, built up out of monotone components. Basic definitions and theorems are provided, as well as an application to the study of a model of one of the cell's most important subsystems.

The NKI-Rockland Sample: A Model for Accelerating the Pace of Discovery Science in Psychiatry.

Abstract: The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls for an acceleration of discovery and the delineation of developmental trajectories for risk and resilience across the lifespan. To attain these objectives, sufficiently powered datasets with broad and deep phenotypic characterization, state-of-the-art neuroimaging, and genetic samples must be generated and made openly available to the scientific community. The enhanced Nathan Kline Institute Rockland Sample (NKI-RS) is a response to this need. NKI-RS is an ongoing, institutionally-centered endeavor aimed at creating a large-scale (N>1000), deeply phenotyped, community-ascertained, lifespan sample (ages 6-85 years old) with advanced neuroimaging and genetics. These data will be publically shared, openly and prospectively (i.e., on a weekly basis). Herein, we describe the conceptual basis of the NKI-RS, including study design, sampling considerations, and steps to synchronize phenotypic and neuroimaging assessment. Additionally, we describe our process for sharing the data with the scientific community while protecting participant confidentiality, maintaining an adequate database, and certifying data integrity. The pilot phase of the NKI-RS, including challenges in recruiting, characterizing, imaging, and sharing data, is discussed while also explaining how this experience informed the final design of the enhanced NKI-RS. It is our hope that familiarity with the conceptual underpinnings of the enhanced NKI-RS will facilitate harmonization with future data collection efforts aimed at advancing psychiatric neuroscience and nosology.