Institution
Rutgers University
Education•New Brunswick, New Jersey, United States•
About: Rutgers University is a education organization based out in New Brunswick, New Jersey, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 68736 authors who have published 159418 publications receiving 6713860 citations. The organization is also known as: Rutgers, The State University of New Jersey & Rutgers.
Topics: Population, Poison control, Context (language use), Cancer, Gene
Papers published on a yearly basis
Papers
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TL;DR: This work proposes a new mechanism for meiotic recombination, in which events are initiated by double-strand breaks that are enlarged to double- Strand gaps, and postmeiotic segregation can result from heteroduplex DNA formed at the boundaries of the gap-repair region.
2,387 citations
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TL;DR: An analytic framework is described to identify and distinguish between moderators and mediators in RCTs when outcomes are measured dimensionally and it is recommended that R CTs routinely include and report such analyses.
Abstract: Randomized clinical trials (RCTs) not only are the gold standard for evaluating the efficacy and effectiveness of psychiatric treatments but also can be valuable in revealing moderators and mediators of therapeutic change. Conceptually, moderators identify on whom and under what circumstances treatments have different effects. Mediators identify why and how treatments have effects. We describe an analytic framework to identify and distinguish between moderators and mediators in RCTs when outcomes are measured dimensionally. Rapid progress in identifying the most effective treatments and understanding on whom treatments work and do not work and why treatments work or do not work depends on efforts to identify moderators and mediators of treatment outcome. We recommend that RCTs routinely include and report such analyses.
2,378 citations
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TL;DR: The cloning and sequencing of both cDNA and genomic clones of GFP from the cnidarian, Aequorea victoria, show three different restriction enzyme patterns which suggests that at least three different genes are present in the A. victoria population.
2,365 citations
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TL;DR: The ability of the Markov model to represent repetitive events and the time dependence of both probabilities and utilities allows for more accurate representation of clinical settings that involve these issues.
Abstract: Markov models are useful when a decision problem involves risk that is continuous over time, when the timing of events is important, and when important events may happen more than once. Representing such clinical settings with conventional decision trees is difficult and may require unrealistic simplifying assumptions. Markov models assume that a patient is always in one of a finite number of discrete health states, called Markov states. All events are represented as transitions from one state to another. A Markov model may be evaluated by matrix algebra, as a cohort simulation, or as a Monte Carlo simulation. A newer representation of Markov models, the Markov-cycle tree, uses a tree representation of clinical events and may be evaluated either as a cohort simulation or as a Monte Carlo simulation. The ability of the Markov model to represent repetitive events and the time dependence of both probabilities and utilities allows for more accurate representation of clinical settings that involve these issues.
2,360 citations
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TL;DR: Virtually all nonequilibrium electron transfers on Earth are driven by a set of nanobiological machines composed largely of multimeric protein complexes associated with a small number of prosthetic groups.
Abstract: Virtually all nonequilibrium electron transfers on Earth are driven by a set of nanobiological machines composed largely of multimeric protein complexes associated with a small number of prosthetic groups. These machines evolved exclusively in microbes early in our planet's history yet, despite their antiquity, are highly conserved. Hence, although there is enormous genetic diversity in nature, there remains a relatively stable set of core genes coding for the major redox reactions essential for life and biogeochemical cycles. These genes created and coevolved with biogeochemical cycles and were passed from microbe to microbe primarily by horizontal gene transfer. A major challenge in the coming decades is to understand how these machines evolved, how they work, and the processes that control their activity on both molecular and planetary scales.
2,345 citations
Authors
Showing all 69437 results
Name | H-index | Papers | Citations |
---|---|---|---|
Salim Yusuf | 231 | 1439 | 252912 |
Daniel Levy | 212 | 933 | 194778 |
Eugene V. Koonin | 199 | 1063 | 175111 |
Eric Boerwinkle | 183 | 1321 | 170971 |
David L. Kaplan | 177 | 1944 | 146082 |
Derek R. Lovley | 168 | 582 | 95315 |
Mark Gerstein | 168 | 751 | 149578 |
Gang Chen | 167 | 3372 | 149819 |
Hongfang Liu | 166 | 2356 | 156290 |
Robert Stone | 160 | 1756 | 167901 |
Mark E. Cooper | 158 | 1463 | 124887 |
Michael B. Sporn | 157 | 559 | 94605 |
Cumrun Vafa | 157 | 509 | 88515 |
Wolfgang Wagner | 156 | 2342 | 123391 |
David M. Sabatini | 155 | 413 | 135833 |