Institution
United States Department of Energy
Government•Washington D.C., District of Columbia, United States•
About: United States Department of Energy is a government organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Catalysis & Coal. The organization has 13656 authors who have published 14177 publications receiving 556962 citations. The organization is also known as: DOE & Department of Energy.
Topics: Catalysis, Coal, Combustion, Adsorption, Hydrogen
Papers published on a yearly basis
Papers
More filters
••
TL;DR: A novel MMOM structure and its room-temperature hydrogen adsorption properties are reported and it is reported that these materials possess physical characteristics similar to those of single-walled carbon nanotubes but also exhibit a number of improved features.
Abstract: Advancement in hydrogen storage techniques represents one of the most important areas of today's materials research. While extensive efforts have been made to the existing techniques, there is no viable storage technology capable of meeting the DOE cost and performance targets at the present time. New materials with significantly improved hydrogen adsorption capability are needed. Microporous metal coordination materials (MMOM) are promising candidates for use as sorbents in hydrogen adsorption. These materials possess physical characteristics similar to those of single-walled carbon nanotubes (SWNTs) but also exhibit a number of improved features. Here, we report a novel MMOM structure and its room-temperature hydrogen adsorption properties.
615 citations
••
TL;DR: It is found that ~20% of new missense mutations in humans result in a loss of function, whereas ~27% are effectively neutral, implying that mutation-selection balance may be a feasible evolutionary mechanism underlying some common diseases.
Abstract: The accumulation of mildly deleterious missense mutations in individual human genomes has been proposed to be a genetic basis for complex diseases. The plausibility of this hypothesis depends on quantitative estimates of the prevalence of mildly deleterious de novo mutations and polymorphic variants in humans and on the intensity of selective pressure against them. We combined analysis of mutations causing human Mendelian diseases, of human-chimpanzee divergence, and of systematic data on human genetic variation and found that ∼20% of new missense mutations in humans result in a loss of function, whereas ∼27% are effectively neutral. Thus, the remaining 53% of new missense mutations have mildly deleterious effects. These mutations give rise to many low-frequency deleterious allelic variants in the human population, as is evident from a new data set of 37 genes sequenced in >1,500 individual human chromosomes. Surprisingly, up to 70% of low-frequency missense alleles are mildly deleterious and are associated with a heterozygous fitness loss in the range 0.001–0.003. Thus, the low allele frequency of an amino acid variant can, by itself, serve as a predictor of its functional significance. Several recent studies have reported a significant excess of rare missense variants in candidate genes or pathways in individuals with extreme values of quantitative phenotypes. These studies would be unlikely to yield results if most rare variants were neutral or if rare variants were not a significant contributor to the genetic component of phenotypic inheritance. Our results provide a justification for these types of candidate-gene (pathway) association studies and imply that mutation-selection balance may be a feasible evolutionary mechanism underlying some common diseases.
614 citations
••
University of California, San Diego1, Stanford University2, United States Department of Energy3, Ghent University4, University of Arizona5, University of California, Los Angeles6, Scripps Research Institute7, Centre national de la recherche scientifique8, University of Mainz9, University of Massachusetts Medical School10, J. Craig Venter Institute11, University of Maryland, College Park12
TL;DR: It is speculated that this latter process may be involved in altering the cell-surface characteristics of each species, and selenoenzymes, novel fusion proteins, and loss of some major protein families including ones associated with chromatin are likely important adaptations for achieving a small cell size.
Abstract: The smallest known eukaryotes, at ≈1-μm diameter, are Ostreococcus tauri and related species of marine phytoplankton. The genome of Ostreococcus lucimarinus has been completed and compared with that of O. tauri. This comparison reveals surprising differences across orthologous chromosomes in the two species from highly syntenic chromosomes in most cases to chromosomes with almost no similarity. Species divergence in these phytoplankton is occurring through multiple mechanisms acting differently on different chromosomes and likely including acquisition of new genes through horizontal gene transfer. We speculate that this latter process may be involved in altering the cell-surface characteristics of each species. In addition, the genome of O. lucimarinus provides insights into the unique metal metabolism of these organisms, which are predicted to have a large number of selenocysteine-containing proteins. Selenoenzymes are more catalytically active than similar enzymes lacking selenium, and thus the cell may require less of that protein. As reported here, selenoenzymes, novel fusion proteins, and loss of some major protein families including ones associated with chromatin are likely important adaptations for achieving a small cell size.
612 citations
••
TL;DR: It is shown that Josephson coupling can be neglected in the high-temperature superconductors only under very stringent conditions.
Abstract: The structure of vortices within an infinite stack of thin superconducting layers is considered and examined in detail in the limit of zero interlayer Josephson coupling The basic building block for the description of three-dimensional (3D) vortex lines is shown to be the 2D pancake vortex, which is a vortex located in only one of the layers; the other layers contain no vortices, but have an important effect in screening the magnetic field generated by currents in the first layer It is shown that 3D vortex lines can be built up by superposing the contributions of stacks of 2D pancake vortices Thermal excitation is shown to break up a single 3D vortex line at a temperature corresponding to the Kosterlitz-Thouless temperature of a single superconducting layer The effect of thermally induced decoupling of the 2D vortex solids in different layers, corresponding to melting only in the direction perpendicular to the layers, is also considered It is shown that Josephson coupling can be neglected in the high-temperature superconductors only under very stringent conditions Although these conditions evidently are not met in ${\mathrm{Bi}}_{2}$${\mathrm{Sr}}_{2}$${\mathrm{CaCu}}_{2}$${\mathrm{O}}_{8}$ and ${\mathrm{Tl}}_{2}$${\mathrm{Ba}}_{2}$${\mathrm{Ca}}_{1}$${\mathrm{Cu}}_{2}$${\mathrm{O}}_{8}$, they should be satisfied in superconducting-insulating multilayer systems, such as ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\delta}}}$/${\mathrm{PrBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\delta}}}$
610 citations
22 Jun 2016
TL;DR: Shehabi, Arman; Smith, Sarah; Sartor, Dale; Brown, Richard; Herrlin, Magnus; Koomey, Jonathan; Masanet, Eric; Horner, Nathaniel; Azevedo, Ines; Lintner, William as discussed by the authors.
Abstract: Author(s): Shehabi, Arman; Smith, Sarah; Sartor, Dale; Brown, Richard; Herrlin, Magnus; Koomey, Jonathan; Masanet, Eric; Horner, Nathaniel; Azevedo, Ines; Lintner, William
606 citations
Authors
Showing all 13660 results
Name | H-index | Papers | Citations |
---|---|---|---|
Martin White | 196 | 2038 | 232387 |
Paul G. Richardson | 183 | 1533 | 155912 |
Jie Zhang | 178 | 4857 | 221720 |
Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
Yang Gao | 168 | 2047 | 146301 |
David Eisenberg | 156 | 697 | 112460 |
Marvin Johnson | 149 | 1827 | 119520 |
Carlos Escobar | 148 | 1184 | 95346 |
Joshua A. Frieman | 144 | 609 | 109562 |
Paul Jackson | 141 | 1372 | 93464 |
Greg Landsberg | 141 | 1709 | 109814 |
J. Conway | 140 | 1692 | 105213 |
Pushpalatha C Bhat | 139 | 1587 | 105044 |
Julian Borrill | 139 | 387 | 102906 |
Cecilia Elena Gerber | 138 | 1727 | 106984 |