Institution
University of Tokyo
Education•Tokyo, Japan•
About: University of Tokyo is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 134564 authors who have published 337567 publications receiving 10178620 citations. The organization is also known as: Todai & Universitas Tociensis.
Topics: Population, Gene, Catalysis, Magnetic field, Galaxy
Papers published on a yearly basis
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TL;DR: It is demonstrated that Foxo3a, a forkhead transcription factor that acts downstream of the PTEN/PI3K/Akt pathway, is critical for HSC self-renewal and plays a pivotal role in maintaining the HSC pool.
767 citations
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TL;DR: In this paper, a moving particle semi-implicit (MPS) algorithm is used for two-dimensional incompressible non-viscous flow analysis and two types of breaking waves, plunging and spilling breakers, are observed in the calculation results.
Abstract: SUMMARY The numerical method used in this study is the moving particle semi-implicit (MPS) method, which is based on particles and their interactions. The particle number density is implicitly required to be constant to satisfy incompressibility. A semi-implicit algorithm is used for two-dimensional incompressible non-viscous flow analysis. The particles whose particle number densities are below a set point are considered as on the free surface. Grids are not necessary in any calculation steps. It is estimated that most of computation time is used in generation of the list of neighboring particles in a large problem. An algorithm to enhance the computation speed is proposed. The MPS method is applied to numerical simulation of breaking waves on slopes. Two types of breaking waves, plunging and spilling breakers, are observed in the calculation results. The breaker types are classified by using the minimum angular momentum at the wave front. The surf similarity parameter which separates the types agrees well with references. Breaking waves are also calculated with a passively moving float which is modelled by particles. Artificial friction due to the disturbed motion of particles causes errors in the flow velocity distribution which is shown in comparison with the theoretical solution of a cnoidal wave. © 1998 John Wiley & Sons, Ltd.
767 citations
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TL;DR: It is reported that placental growth factor (PGF) regulates inter- and intramolecular cross talk between the VEGF RTKs Flt1 and Flk1, which is likely to have therapeutic implications, as treatment with VegF/PGF heterodimer or a combination of VEGf plus PGF increased ischemic myocardial angiogenesis in a mouse model that was refractory to V EGF alone.
Abstract: Therapeutic angiogenesis is likely to require the administration of factors that complement each other. Activation of the receptor tyrosine kinase (RTK) Flk1 by vascular endothelial growth factor (VEGF) is crucial, but molecular interactions of other factors with VEGF and Flk1 have been studied to a limited extent. Here we report that placental growth factor (PGF, also known as PlGF) regulates inter- and intramolecular cross talk between the VEGF RTKs Flt1 and Flk1. Activation of Flt1 by PGF resulted in intermolecular transphosphorylation of Flk1, thereby amplifying VEGF-driven angiogenesis through Flk1. Even though VEGF and PGF both bind Flt1, PGF uniquely stimulated the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Furthermore, the VEGF/PGF heterodimer activated intramolecular VEGF receptor cross talk through formation of Flk1/Flt1 heterodimers. The inter- and intramolecular VEGF receptor cross talk is likely to have therapeutic implications, as treatment with VEGF/PGF heterodimer or a combination of VEGF plus PGF increased ischemic myocardial angiogenesis in a mouse model that was refractory to VEGF alone.
766 citations
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TL;DR: In this article, the authors calculate the evolution of heavy-element abundances from C to Zn in the solar neighborhood, adopting their new nucleosynthesis yields for wide ranges of metallicity (Z = 0-Z☉) and the explosion energy (normal supernovae and hypernovae).
Abstract: We calculate the evolution of heavy-element abundances from C to Zn in the solar neighborhood, adopting our new nucleosynthesis yields. Our yields are calculated for wide ranges of metallicity (Z = 0-Z☉) and the explosion energy (normal supernovae and hypernovae), based on the light-curve and spectra fitting of individual supernovae. The elemental abundance ratios are in good agreement with observations. Among the α-elements, O, Mg, Si, S, and Ca show a plateau at [Fe/H] -1, while Ti is underabundant overall. The observed abundance of Zn ([Zn/Fe] ~ 0) can be explained only by the high-energy explosion models, as it requires a large contribution of hypernovae. The observed decrease in the odd-Z elements (Na, Al, and Cu) toward low [Fe/H] is reproduced by the metallicity effect on nucleosynthesis. The iron-peak elements (Cr, Mn, Co, and Ni) are consistent with the observed mean values at -2.5 [Fe/H] -1, and the observed trend at the lower metallicity can be explained by the energy effect. We also show the abundance ratios and the metallicity distribution functions of the Galactic bulge, halo, and thick disk. Our results suggest that the formation timescale of the thick disk is ~1-3 Gyr.
766 citations
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TL;DR: This work reports that the influenza A virus nonstructural protein 1 (NS1) specifically inhibits TRIM25-mediated RIG-I CARD ubiquitination, thereby suppressing Rig-I signal transduction and revealing a mechanism by which influenza virus inhibits host IFN response.
765 citations
Authors
Showing all 135252 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ronald C. Kessler | 274 | 1332 | 328983 |
Donald P. Schneider | 242 | 1622 | 263641 |
George M. Whitesides | 240 | 1739 | 269833 |
Jing Wang | 184 | 4046 | 202769 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Yusuke Nakamura | 179 | 2076 | 160313 |
Dennis J. Selkoe | 177 | 607 | 145825 |
David L. Kaplan | 177 | 1944 | 146082 |
D. M. Strom | 176 | 3167 | 194314 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
Yang Yang | 164 | 2704 | 144071 |
Qiang Zhang | 161 | 1137 | 100950 |
Kenji Kangawa | 153 | 1117 | 110059 |
Takashi Taniguchi | 152 | 2141 | 110658 |