Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
Reads0
Chats0
TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
Citations
More filters
Journal ArticleDOI
At the tipping point for epigenetic therapies in cancer
TL;DR: The Reviews in this issue of the JCI highlight ongoing efforts to translate the understanding of the cancer epigenome into successful interventional strategies in the clinic.
Journal ArticleDOI
Epigenetic regulation of prostate cancer
TL;DR: The current literature on epigenetic changes associated with prostate cancer is examined and the potential use of epigenetic modifiers for treatment of this disease is discussed.
Journal ArticleDOI
Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications.
TL;DR: This is the first report demonstrating a molecular mechanism at the chromatin level underlying tissue-specific glycan expression, and several other neural glycosyltransferase genes are also found to be regulated by epigenetic histone modifications.
Book ChapterDOI
Role of Aneuploidy in Early and Late Stages of Neoplastic Progression of Syrian Hamster Embryo Cells in Culture
TL;DR: There is increasing evidence in support of the somatic mutation theory of carcinogenesis, such as the demonstration of DNA as a critical target in neoplastic transformation and the correlation between mutagenesis and carcinogenesis with most chemicals.
Journal ArticleDOI
Epigenomics and ovarian carcinoma
TL;DR: The importance of the ovarian carcinoma epigenome for development of diagnostic and prognostic biomarkers, and the current epigenetic therapies used in ovarian cancer are discussed.
References
More filters
Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.