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Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine
Jia Yu,Bo Qin,Ann M. Moyer,Somaira Nowsheen,Tongzheng Liu,Sisi Qin,Yongxian Zhuang,Duan Liu,Shijia W. Lu,Krishna R. Kalari,Daniel W. Visscher,John A. Copland,Sarah A. McLaughlin,Alvaro Moreno-Aspitia,Donald W. Northfelt,Richard Gray,Zhenkun Lou,Vera J. Suman,Richard M. Weinshilboum,Judy C. Boughey,Matthew P. Goetz,Liewei Wang +21 more
TL;DR: A potential mechanism of regulating DNMT protein degradation and DNMT levels as response biomarkers for DNMT inhibitors in TNBCs is suggested.
Journal ArticleDOI
Multistage carcinogenesis involves multiple genes and multiple mechanisms.
I. Bernard Weinstein,Sebastiano Gattoni-Celli,Paul T. Kirschmeier,Michael E. Lambert,Hsiao W,Joseph M. Backer,Alan M. Jeffrey +6 more
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Overview of Cancer Epigenetics
TL;DR: Current knowledge suggests that agents that intervene in this process by "turning back on" silenced genes may represent a significant advancement in treating many forms of cancer.
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Demethylating agents in myeloid malignancies.
TL;DR: Demethylating agents are the standard of care for patients with higher risk MDS and the only agent known to improve the natural history of MDS.
Journal ArticleDOI
Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics
TL;DR: It appears that changes in the kinetics of erythroid cell differentiation rather than direct action on the gamma genes underlie stimulation of fetal hemoglobin in the adult animals in vivo, suggesting that chemotherapeutic agents selected for their low carcinogenic or mutagenic potential could be used for therapeutic induction of fetal Hemoglobin in patients with sickle cell anemia.
References
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A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
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X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.