Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
Reads0
Chats0
TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
Citations
More filters
Book ChapterDOI
Tubulins from Plants, Fungi, and Protists
TL;DR: The purpose in this review is to catalogue the recent body of work that has come from studies on tubulins from plants, fungi, and protists and to provide some perspective on the differences and similarities between these nonanimal Tubulins and their animal counterparts.
Journal ArticleDOI
Epigenetic "bivalently marked" process of cancer stem cell-driven tumorigenesis.
TL;DR: Results suggest a possible mechanism by which aberrant differentiation, mediated by histone and DNA methylation, instigates tumor progression.
Journal ArticleDOI
Activation of estrogen receptor alpha by decitabine inhibits osteosarcoma growth and metastasis
Maria Angeles Lillo Osuna,Jesus Garcia-Lopez,Ikbale El Ayachi,Iram Fatima,Aysha B. Khalid,Jerusha Kumpati,Alexandria V. Slayden,Tiffany N. Seagroves,Gustavo A. Miranda-Carboni,Susan A. Krum +9 more
TL;DR: Preclinical evidence is provided that the FDA-approved DNA methylation inhibitor DAC may be repurposed to treat patients with osteosarcoma based on its efficacy to decrease proliferation, to induce osteoblast differentiation, and to reduce metastasis to visceral organs.
Journal ArticleDOI
Novel therapies for myelodysplastic syndromes
Stefan Faderl,Hagop Kantarjian +1 more
TL;DR: The assessment of patients with myelodysplastic syndromes and the choice of therapies remain challenging, but new therapies are now emerging after the identification of molecular targets that result in improvement of hematologic parameters and may hold promise for the prevention of disease progression.
Journal ArticleDOI
Glycine N-Methyltransferase Is an Example of Functional Diversity ROLE AS A POLYCYCLIC AROMATIC HYDROCARBON-BINDING RECEPTOR
Rashid Bhat,Edward Bresnick +1 more
TL;DR: It is unequivocally establish that GNMT is a PAH-binding protein that can mediate the induction of CYP1A1 by PAHs such as B[a]P through an Ah receptor-independent pathway.
References
More filters
Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.