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Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy.
Helen Loo Yau,Helen Loo Yau,Ilias Ettayebi,Ilias Ettayebi,Daniel D. De Carvalho,Daniel D. De Carvalho +5 more
TL;DR: Accumulating evidence supports the potential of using epigenetic therapy to not only reactivate silenced genes in cancer cells, but to also increase antitumor immunogenicity, by reactivation of endogenous retroviruses, to increase tumor immune-infiltration, and to reinvigorate T cell exhaustion.
Journal ArticleDOI
MOM1 and Pol-IV/V interactions regulate the intensity and specificity of transcriptional gene silencing.
Chotika Yokthongwattana,Chotika Yokthongwattana,Etienne Bucher,Marian Čaikovski,Isabelle Vaillant,Joël Nicolet,Ortrun Mittelsten Scheid,Jerzy Paszkowski,Jerzy Paszkowski +8 more
TL;DR: Evidence that Pol‐V is required for MOM1‐mediated suppression of transcription at a subset of its chromosomal targets is provided and genetically interacts with MOM 1 in the control of gene silencing, indicating functional cooperation of MOM2 and Pol-V not only broadens the range of the controlled loci in comparison to each individual factor, but also determines the degree of TGS.
Journal ArticleDOI
Therapy with azanucleosides for myelodysplastic syndromes
TL;DR: This article critically appraise the most relevant clinical data reported on the use of azanucleosides for the treatment of patients with MDS.
Journal ArticleDOI
Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets.
Nasir Javaid,Sangdun Choi +1 more
TL;DR: This review has highlighted mechanistic and structural interactions of the main epigenetic families with their targets, which will help to identify more efficient and safe drugs against several diseases.
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Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance.
L A Michalowsky,P A Jones +1 more
TL;DR: The differential binding of proteins to hypomethylated, azacytosine-containing DNA may mediate a novel mechanism of drug resistance and disrupt replication and transcription and instigate cell death.
References
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A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
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X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.