Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
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TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
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DNA and the chromosome - varied targets for chemotherapy
TL;DR: Some of the new drugs aimed at primary DNA sequences, DNA secondary structures, and associated proteins are discussed, keeping in mind that these agents are not only important from a clinical perspective but also as tools for understanding the nuclear environment in normal and cancer cells.
Journal ArticleDOI
In vitro methylation of the promoter and enhancer of Pro alpha 1(I) collagen gene leads to its transcriptional inactivation.
TL;DR: Findings suggest that DNA methylation may be an important mechanism of transcriptional inactivation of interstitial collagen genes.
Journal ArticleDOI
SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome
Carmen S. Tellez,Marcie J. Grimes,Maria A. Picchi,Yushi Liu,Thomas H. March,Matthew D. Reed,Aram Oganesian,Pietro Taverna,Steven A. Belinsky +8 more
TL;DR: Preclinical in vivo findings demonstrate the clinical potential of SGI‐110 for reducing lung tumor burden through reprogramming the epigenome and demonstrate the effectiveness of DNMT inhibitors against solid tumors.
Journal ArticleDOI
Targeting Histone Methylation in Cancer.
TL;DR: The rationale for targeting histone methylation in oncology is presented and a few key targets that are being investigated in the clinic are provided, including histone lysine methyltransferases such as enhancer of zeste homolog 2 and DOT1L.
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Experimental condensation inhibition in constitutive and facultative heterochromatin of mammalian chromosomes.
Thomas Haaf,M. Schmid +1 more
TL;DR: It is proposed that both DNA hypomethylation and steric alterations in chromosomal DNA may interfere with the binding of specific proteins or multi-protein complexes that are required for chromosome condensation.
References
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Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.