Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
Reads0
Chats0
TLDR
Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.About:
This article is published in Cell.The article was published on 1980-05-01. It has received 1722 citations till now. The article focuses on the topics: DNA methylation & Zebularine.read more
Citations
More filters
Journal ArticleDOI
Genetics of Dopamine and its Contribution to Cocaine Addiction
TL;DR: The literature on genetic variations that affect dopamine neurotransmission, responses to psychostimulants and potential treatments for cocaine addiction are reviewed and pharmacotherapies may have increased efficacy when targeted to individuals possessing specific genetic polymophisms in dopamine’s metabolic and intracellular messenger systems.
Journal ArticleDOI
GSTP1 DNA methylation and expression status is indicative of 5-aza-2′-deoxycytidine efficacy in human prostate cancer cells
TL;DR: It is shown that GSTP1 DNA methylation and protein expression status is correlated with DNMTi treatment response in prostate cancer cells and these results warrant its testing as a marker of epigenetic therapy response in future clinical trials.
Journal ArticleDOI
Increased metallothionein content in rat liver and kidney following X-irradiation.
Noriyuki Shiraishi,Hiromichi Yamamoto,Yoshihiro Takeda,Shintaroh Kondoh,Hidehiro Hayashi,Keiji Hashimoto,Kaname Aono +6 more
TL;DR: Data indicate that X-ray treatment produces an in vivo induction of hepatic and renal MT synthesis, and zinc was decreased in the spleen and thymus, and increased in the liver or kidney 18 hr after irradiation (2000 rad).
Journal ArticleDOI
Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine in anaplastic large cell lymphoma
Melanie R. Hassler,Aleksandra Klisaroska,Karoline Kollmann,Irene Steiner,Martin Bilban,Ana-Iris Schiefer,Veronika Sexl,Gerda Egger +7 more
TL;DR: It is demonstrated that 5-aza-CdR exhibits high antineoplastic activity against anaplastic large cell lymphoma (ALCL), a rare CD30 positive non-Hodgkin lymphoma of T-cell origin and warrants further clinical evaluation for future therapeutic use.
Journal ArticleDOI
Anti-tumoral effect of the non-nucleoside DNMT inhibitor RG108 in human prostate cancer cells.
Inês Graça,Elsa Joana Sousa,Tiago Baptista,Mafalda Almeida,João Ramalho-Carvalho,Carlos M. Palmeira,Rui Henrique,Carmen Jerónimo +7 more
TL;DR: RG108 is an effective tumor growth suppressor in most PCa cell lines tested and is likely mediated by reversion of aberrant DNA methylation affecting cancer related-genes epigenetically silenced in PCa.
References
More filters
Journal ArticleDOI
A procedure for the isolation of deoxyribonucleic acid from micro-organisms
TL;DR: A method has been described for the isolation of DNA from micro-organisms which yields stable, biologically active, highly polymerized preparations relatively free from protein and RNA, and Representative samples have been characterized for their thermal stability and sedimentation behaviour.
Journal ArticleDOI
DNA modification mechanisms and gene activity during development.
Robin Holliday,J. E. Pugh +1 more
TL;DR: This article suggests mechanisms that may account for the differentiated state of dividing or nondividing cells and that also attempt to explain the ordered switching on or off of genes during development.
Journal ArticleDOI
X inactivation, differentiation, and DNA methylation.
TL;DR: A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation using sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate half-methylated sites.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal Article
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.
TL;DR: No spontaneous transformation in vitro has been observed in the stock cultures transferred on a regular schedule and tests for tumorigenicity at all passages were negative.